The Cerebellum Is Related to Cognitive Dysfunction in White Matter Hyperintensities

Cao, Shanshan; Nie, Jiajia; Zhang, Jun; Chen, Chen; Wang, Xiaojing; Liu, Yuanyuan; Mo, Yuting; Du, Baogen; Hu, Yajuan; Tian, Yanghua; Wei, Qiang; Wang, Kai

doi:10.3389/fnagi.2021.670463

Cited by 10 publications

(5 citation statements)

References 42 publications

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“…Moreover, multiple cerebral functional networks map onto the cerebellum, including visual, sensorimotor, dorsal attention, ventral attention, and default functions ( Schmahmann et al, 2019 ). The atrophy of the cerebellum was found to be increasingly associated with the severity of WMH and related to memory function in WMH patients ( Cao et al, 2021 ). However, little is currently known of the function of the cerebellum during GBD in CSVD patients.…”

Section: Introductionmentioning

confidence: 99%

Altered neuroimaging patterns of cerebellum and cognition underlying the gait and balance dysfunction in cerebral small vessel disease

Mao²,

Yang³

et al. 2023

Front. Aging Neurosci.

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BackgroundThe mechanism of gait and balance dysfunction (GBD) in cerebral small vessel disease (CSVD) remains unclear. Evidence supports cognition engages in GBD of CSVD. The cerebellum is important in motor and cognition, while little is known about the influence of the cerebellum on GBD in CSVD.MethodsThis study is a retrospective cohort study. All participants of this study were enrolled from the CSVD individuals in Nanjing Drum Tower Hospital from 2017 to 2021. The GBD of CSVD patients was defined as Tinetti Test score ≤ 23. Cerebral cortical thickness, cerebellar gray matter volume, the amplitude of low-frequency fluctuation, functional connectivity, and modular interaction were calculated to determine the cortical atrophy and activity patterns of CSVD patients with GBD. The effect of cognitive domains during GBD in CSVD patients was explored by correlation analyses.ResultsA total of 25 CSVD patients were recruited in CSVD patients with GBD group (Tinetti Test score ≤ 23, mean age ± standard deviation: 70.000 ± 6.976 years), and 34 CSVD patients were recruited in CSVD patients without GBD group (Tinetti Test score > 23, mean age ± standard deviation: 64.029 ± 9.453 years). CSVD patients with GBD displayed worse cognitive performance and cortical atrophy in the right cerebellum VIIIa and bilateral superior temporal gyrus than those without GBD. The right postcentral gyrus, left inferior temporal gyrus, right angular gyrus, right supramarginal gyrus and right middle frontal gyrus were functionally overactivated and showed decreased modular interaction with the right cerebellum. Tinetti Test scores were negatively related to the volume of the right cerebellum VIIIa in CSVD patients with GBD. Notably, memory, especially visuospatial memory, was greatly associated with GBD in CSVD.ConclusionThe cortical atrophy and altered functional activity in sensorimotor area and ventral attention network in the cerebellum and cerebrum may underlying the GBD in CSVD. Memory might be critically cognitively responsible for GBD in CSVD.

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Section: Introductionmentioning

confidence: 99%

Altered neuroimaging patterns of cerebellum and cognition underlying the gait and balance dysfunction in cerebral small vessel disease

Mao²,

Yang³

et al. 2023

Front. Aging Neurosci.

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“…Such changes correlated with WMH and cognitive impairments widely associated with the cSVD condition 141 . More recently, decreased GM volume and FC of the cerebellum were associated with cognitive impairment in cSVD patients 142 …”

Section: Resultsmentioning

confidence: 72%

“…141 More recently, decreased GM volume and FC of the cerebellum were associated with cognitive impairment in cSVD patients. 142 In patients with severe WMH load, impaired FC and structural connectivity between the posterior cingulate cortex (PCC) and thalamus were independent risk factors for slower IPS. By contrast, PCC-middle frontal gyrus FC and PCC-hippocampus structural connectivity were related to memory decline.…”

Section: Functional Magnetic Resonance Imagingmentioning

confidence: 99%

Contrast agent‐free state‐of‐the‐art magnetic resonance imaging on cerebral small vessel disease – Part 2: Diffusion tensor imaging and functional magnetic resonance imaging

et al. 2022

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“…Disruption of cerebral WM structures can lead to hippocampal atrophy ( 77 ), inducing cognitive impairment and dementia ( 78 ). These WM structural disruptions are mainly caused by cerebral small vessel disease ( 79 ). Age-related structural disruption of WM is associated with cognitive decline in a healthy elderly people ( 80 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of long-term exposure to high altitude on brain structure in healthy people: an MRI-based systematic review and meta-analysis

et al. 2023

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PurposeTo conduct a systematic review and meta-analysis of observational studies of brain MRI, this paper assesses the effects of long-term exposure to high-altitude on brain structures in healthy people.MethodsObservational studies related to high-altitude, brain and MRI were systematically searched based on data retrieved from PubMed, Embase and Cochrane Library. The timescale for collecting literature was from the establishment of the databases to 2023. NoteExpress 3.2 was used to manage the literature. Two investigators performed literature screening and data extraction based on inclusion criteria, exclusion criteria, and literature quality. The quality of the literature was assessed using the NOS Scale. Finally, meta-analysis of included studies was performed using Reviewer Manager 5.3.ResultsInitially, 3,626 articles were retrieved. After screening, 16 articles (n = 756 participants) were included in the systematic review, and meta-analysis was performed on 6 articles (n = 350 participants). The overall quality of the included articles was at medium level, with a mean NOS score of 5.62. The results of meta-analysis showed that the differences between the HA group and LA group were not statistically significant, in total GM volume (MD: −0.60, 95% CI: −16.78 to 15.58, P = 0.94), WM volume (MD: 3.05, 95% CI: −15.72 to 21.81, P = 0.75) and CSF volume (MD: 5.00, 95% CI: −11.10 to 21.09, P = 0.54).The differences between HA and LA in FA values of frontotemporal lobes were not statistically significant: right frontal lobe (MD: −0.02, 95% CI: −0.07 to 0.03, P = 0.38), left frontal lobe (MD: 0.01, 95% CI: −0.02 to 0.04, P = 0.65), right temporal lobe (MD: −0.00, 95% CI: −0.03 to 0.02, P = 0.78) and left temporal lobe (MD: −0.01, 95% CI: −0.04 to 0.02, P = 0.62). However, there were significant differences in GM volume, GM density and FA values in local brain regions between HA group and LA group.ConclusionCompared with LA area, there were no significant differences in total GM, WM and CSF volumes in healthy people living at high-altitude area for long-term, while there were significant differences in GM volume and FA values in local brain regions. Long-term exposure to high-altitude area caused the adaptive structural changes in local brain regions. Since heterogeneity existed between the studies, further studies are needed to uncover the effects of high-altitude on brain of healthy people.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42023403491.

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The Cerebellum Is Related to Cognitive Dysfunction in White Matter Hyperintensities

Cited by 10 publications

References 42 publications

Altered neuroimaging patterns of cerebellum and cognition underlying the gait and balance dysfunction in cerebral small vessel disease

Altered neuroimaging patterns of cerebellum and cognition underlying the gait and balance dysfunction in cerebral small vessel disease

Contrast agent‐free state‐of‐the‐art magnetic resonance imaging on cerebral small vessel disease – Part 2: Diffusion tensor imaging and functional magnetic resonance imaging

Effects of long-term exposure to high altitude on brain structure in healthy people: an MRI-based systematic review and meta-analysis

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