The chance of having a healthy normal child following intracytoplasmic morphologically-selected sperm injection (IMSI) treatment is higher compared to conventional IVF-ICSI treatment

Berkovitz, Arie; Eltes, F.; Paul, Marilyn S.; Adrian, E. D.; Benjamin, Barak

doi:10.1016/j.fertnstert.2007.07.083

Cited by 33 publications

(21 citation statements)

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“…It has been reported that the negative impact of large nuclear vacuoles (LNV) is perceptible after the onset of the EGA, leading to reduced blastocyst formation [28][29][30][31]. Moreover, LNV also affect ongoing pregnancy rates [31][32][33][34], miscarriage rates [31,33,[35][36][37], and malformation in offspring [38,39].…”

Section: Introductionmentioning

confidence: 99%

The impact of paternal factors on cleavage stage and blastocyst development analyzed by time-lapse imaging—a retrospective observational study

Neyer

Zintz

Stecher

et al. 2015

J Assist Reprod Genet

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Purpose Various time-lapse studies have postulated embryo selection criteria based on early morphokinetic markers. However, late paternal effects are mostly not visible before embryonic genome activation. The primary objective of this retrospective study was to investigate whether those early morphokinetic algorithms investigated by time-lapse imaging are reliable enough to allow for the accurate selection of those embryos that develop into blastocysts, while of course taking into account the correlation with the type of injected spermatozoa. Methods During a period of 18 months, a total of 461 MII oocytes from 43 couples with severe male factor infertility and previous Bexternal^IVF failures after cleavage-stage embryo transfer (ET) were fertilized by intracytoplasmic morphologically selected sperm injection (IMSI). Thereof, 373 embryos were monitored in a time-lapse incubator until ET on day 5. Blastocyst outcome in combination with three previously postulated MKc (cc2: t3-t2, 5-12 h; t3, 35-40 h; t5, 48-56 h) and the morphology of the selected sperm were analyzed. Results A significant increase in the rate of blastocysts (54.0 vs. 36.3 %; P<0.01) and top blastocysts (25.3 vs. 10.8 %; P<0.001) was observed in the group of those meeting all three morphokinetic criteria (MKc3). However, MKc3 were only met in 23.3 % of all embryos. Moreover, TBR was influenced by the type of injected spermatozoa. In both groups, TBR decreased dramatically (MKc3, 35.0 vs. 17.0 %; MKc<3, 14.2 vs. 8.4 %) when class II/III sperm instead of class I were injected. Conclusion Early morphokinetic parameters might give some predictive information but fail to serve as a feasible selective tool for the prediction of blastocyst development given the influence of the type of spermatozoa injected.

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Section: Introductionmentioning

confidence: 99%

The impact of paternal factors on cleavage stage and blastocyst development analyzed by time-lapse imaging—a retrospective observational study

Neyer

Zintz

Stecher

et al. 2015

J Assist Reprod Genet

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show abstract

“…5 Berkovitz et al confirmed that the selection and the subsequent injection of spermatozoa with normal nuclear morphology reduced the risk of major fetal malformations. 12 Setti et al reported similar clinical outcomes in couples undergoing either IMSI or ICSI, except that a significantly higher fertilization rate was observed in the former procedure. 23 Knez et al reported that The IMSI group was characterized by a higher number of blastocysts per cycle than the ICSI group (0.80 vs. 0.65) after a prolonged 5-day embryo culture with a tendency toward higher implantation and pregnancy rates per cycle was achieved in the IMSI group compared to the ICSI group (17.1% vs. 6.8%; 25.0% vs. 8.1%, respectively).…”

Section: Discussionmentioning

confidence: 87%

Comparative study between intracytoplasmic morphologically selected sperm injection versus intracytoplasmic sperm injection in patients with severe male factor infertility and repeated intra cytoplasmic sperm injection failure

Orief

Elabd

Said

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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“…In addition, according to Berkovitz et al [ 20 ] sperm nucleus morphological normality, assessed at high magnifi cation, could decrease the prevalence of major fetal malformations in ICSI offspring. Recently, Cassuto et al [ 21 ] compared the risk of major malformations of children born after standard ICSI and after IMSI, a prospective population-based study was conducted from 2005 to 2010.…”

Section: Msome and Sperm Nuclear Vacuolesmentioning

confidence: 99%

Motile Sperm Organelle Morphology Examination (MSOME)

Franco

2014

Non-Invasive Sperm Selection for in Vitro Fertilization

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The chance of having a healthy normal child following intracytoplasmic morphologically-selected sperm injection (IMSI) treatment is higher compared to conventional IVF-ICSI treatment

Cited by 33 publications

References 0 publications

The impact of paternal factors on cleavage stage and blastocyst development analyzed by time-lapse imaging—a retrospective observational study

The impact of paternal factors on cleavage stage and blastocyst development analyzed by time-lapse imaging—a retrospective observational study

Comparative study between intracytoplasmic morphologically selected sperm injection versus intracytoplasmic sperm injection in patients with severe male factor infertility and repeated intra cytoplasmic sperm injection failure

Motile Sperm Organelle Morphology Examination (MSOME)

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