The change of circulating insulin like growth factor binding protein 7 levels may correlate with postoperative cognitive dysfunction

Jiang, Jue; Chen, Zhifeng; Liang, Bing; Jia, Yan; Zhang, Ying; Xu, Hanlin; Huang, Yan; Jiang, Hong

doi:10.1016/j.neulet.2014.12.046

Cited by 9 publications

(11 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IGFBP-7 plays an important controlling role in memory consolidation [32]. Changes in IGFBP-7 levels have been correlated with postoperative cognitive dysfunction and AD-like memory impairments [27,45]. Our present study demonstrated that the levels of both serum IGFBP-3 and IGFBP-7 were markedly reduced in schizophrenia patients, while there was no significant association between either IGFBP-3 or IGFBP-7 levels and the psychotic and cognitive symptoms in the patients.…”

Section: Plos Onesupporting

confidence: 44%

Altered insulin-like growth factor-2 signaling is associated with psychopathology and cognitive deficits in patients with schizophrenia

et al. 2020

View full text Add to dashboard Cite

BackgroundSchizophrenia is linked with abnormal brain neurodevelopment, on which IGF-2 (insulin-like growth factor-2) has a great impact. The purpose of this study was to assess the levels of serum IGF-2 and its binding proteins IGFBP-3 and IGFBP-7 in schizophrenia patients and the associations of these proteins with schizophrenia psychopathology and cognitive deficits. -Q, et al. (2020) Altered insulin-like growth factor-2 signaling is associated with psychopathology and cognitive deficits in patients with schizophrenia. PLoS ONE 15(3): e0226688. ConclusionsOur study demonstrates that serum IGF-2 was significantly correlated with negative and cognitive symptoms in patients with schizophrenia, suggesting that altered IGF-2 signaling may be implicated in the psychopathology and cognitive deficits in schizophrenia. BackgroundAccording to a hypothesis about schizophrenia, if an adult suffers from severe mental illness, the central nervous system must have developed in a disrupted manner [1,2]. This has been widely indicated by studies in areas of epidemiology, genetics and neuroimaging [3]. For example, structural brain abnormalities are apparent in the beginning stages of schizophrenia [4,5]; there were cases in which young people frequently suffered abnormal cognition and emotion abilities just before the appearance of the mental illness [6]; and primates suffering neonatal lesions had a disabled motion capability [7].As a type of insulin-like protein, insulin-like growth factor (IGF) is an integral component of the cell system in human bodies that serves as a communication channel regarding the physiological circumstances [8]. Accumulated evidence has convincingly demonstrated that IGF has an indispensable and crucial role to play in nerve growth [9]. During the development of brains, IGF signaling regulates the growth survival, maturations, and proliferation of many types of nerve cells, such as astrocytes, oligodendrocytes, NPC (nerve precursor cell) and NSC (nerve stem cell) [9]. In addition, IGF sends basic signals to NSC cells directing them to grow into particular lineages in early development and influences their specific biological roles in late development, with the help of other nerve signals [9]. Individuals suffering from IGF gene mutations are vulnerable to physically disabled growth, nanocephaly or intellectual disability [10,11,12].Two different IGF ligands, insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-2 (IGF-2), have drawn much attention in recent studies. Researchers have shown that IGF-1 signaling plays a role in schizophrenia pathogenesis [13,14,15]. Specifically, plasma IGF-1 levels were decreased in antipsychotic-naive schizophrenia patients and were inversely correlated with positive symptom scores and hallucination subscores [13]. Antipsychotic treatment can increase serum IGF-1 levels in schizophrenia patients, and those patients with a greater increase showed a reduction in positive symptom scores to a higher extent [14]. Palomino et al. studied and showed that the...

show abstract

Section: Plos Onesupporting

confidence: 44%

Altered insulin-like growth factor-2 signaling is associated with psychopathology and cognitive deficits in patients with schizophrenia

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The study was performed in patients scheduled for elective head and neck carcinoma surgery under general anesthesia. The data can be seen in our previous work (Jiang et al 2015 ). All patients underwent a standardized clinical evaluation that included medical history and cognitive function assessment (mini-mental state examination; MMSE) (Rosario 2010 ).…”

Section: Methodssupporting

confidence: 53%

“…In contrast to IGFBP1 to IGFBP6, which bind to the IGFs (Firth and Baxter 2002 ), IGFBP7 is a critical regulator of memory consolidation that can attenuate the function of ILPs (Agbemenyah et al 2013 ) and can directly bind to the IGF-1R and thereby inhibit its activity (Evdokimova et al 2012 ). The relationship between circulating IGFBP7 level and POCD had been discussed in previous work (Jiang et al 2015 ).…”

Section: Introductionmentioning

confidence: 87%

See 1 more Smart Citation

Insulin-like growth factor-1 and insulin-like growth factor binding protein 3 and risk of postoperative cognitive dysfunction

et al. 2015

Self Cite

View full text Add to dashboard Cite

Insulin-like growth factor (IGF)-1 is implicated in learning and memory. Experimental studies have suggested that the IGF-1 system is beneficial in cognition, especially in Alzheimer’s disease (AD), by opposing Aβ amyloid processing and hyperphosphorylated tau toxicity. Low IGF-I and insulin-like growth factor binding protein (IGFBP)-3 serum levels are significantly associated with AD. To assess the relationship between circulating IGF-I and IGFBP3 levels and change of postoperative cognition. The study was performed in patients scheduled for elective head and neck carcinoma surgery under general anesthesia. On the day before the operation and postoperative days 1, 3 and 7, mini-mental state examination (MMSE) was performed by the same doctor, and blood samples were collected at 08:00 h after overnight fasting. The circulating levels of IGF-1 and IGFBP3 were measured by enzyme-linked immunosorbent assay. One hundred and two patients completed all four MMSE tests and forty-four of them completed all the four blood samples collection. Postoperative circulating IGF-1 level, ratio of IGF-1/IGFBP3 and MMSE score significantly decreased, whereas IGFBP3 level significantly increased compared with preoperative values in total patients. The change trends of circulating IGF-1 level and MMSE score were similar. Preoperative circulating IGF-1 level, ratio and MMSE score were significantly lower in POCD group compared to non-POCD group. There was no significant difference in preoperative level of circulating IGFBP3 between the two groups. Preoperative circulating IGF-1 level was negatively correlated with age and positively with MMSE. Logistic regression analysis revealed that lower preoperative IGF-1 level and elderly patients increased the odds of POCD. Down-regulation of circulating IGF-1 level may be involved in the mechanism of postoperative cognitive dysfunction. Older patients had lower circulating IGF-1 levels and were more susceptible to POCD.

show abstract

“…Study staff were blinded to whether the patients had POCD in completing the postoperative questionnaires. According to MMSE score and the ΔMMSE >2, the patient was considered to have developed POCD [10]. In our study, 142 elderly patients were divided into a POCD group and a non-POCD group according to MMSE score, and ABO blood types were analyzed.…”

Section: Methodsmentioning

confidence: 99%

Association Between ABO Blood Type and Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Unilateral Total Hip Arthroplasty Surgery in China

Zhou

Wan

et al. 2017

Med Sci Monit

View full text Add to dashboard Cite

BackgroundPostoperative cognitive dysfunction (POCD) is a postoperative complication after surgery and anesthesia. Whether ABO blood types are associated with POCD in elderly patients undergoing unilateral total hip arthroplasty surgery in China is unclear.Material/MethodsFirstly, 142 elderly patients were divided into a POCD group and a non-POCD group according to the Mini Mental State Examination (MMSE) scores and ABO blood types were analyzed. Secondly, according to ABO blood type, the selected 226 patients were divided into 4 groups: type A group, type B group, type AB group, and type O group. Then, all patients completed the MMSE before and after surgery. Finally, the occurrence of POCD was recorded and related data were analyzed.ResultsFirstly, there was a significant difference in both groups in terms of distribution of ABO blood types, and elderly patients who developed POCD were more likely to have type A blood and less likely to have type O blood. Secondly, compared with elderly patients with type A blood, those with type O had higher MMSE scores on the first day and the seventh day after surgery. Finally, the risk of developing POCD was significantly higher in patients with type A blood and on the first day and the seventh day after surgery the risk of developing POCD was significantly lower in patients with type O blood.ConclusionsElderly patients with type A blood have higher risk of developing early POCD and those with type O blood have less risk of developing early POCD.

show abstract

The change of circulating insulin like growth factor binding protein 7 levels may correlate with postoperative cognitive dysfunction

Cited by 9 publications

References 40 publications

Altered insulin-like growth factor-2 signaling is associated with psychopathology and cognitive deficits in patients with schizophrenia

Altered insulin-like growth factor-2 signaling is associated with psychopathology and cognitive deficits in patients with schizophrenia

Insulin-like growth factor-1 and insulin-like growth factor binding protein 3 and risk of postoperative cognitive dysfunction

Association Between ABO Blood Type and Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Unilateral Total Hip Arthroplasty Surgery in China

Contact Info

Product

Resources

About