The change of tissue of inhibitor metalloproteinase 1 (timp-1) after rosella (hibiscus sabdariffa) extract gel application on artificial crown patients with gingivitis

Abstract

Objective: This study was to investigate the increase of TIMP-1 gingival clavicular fluid ater application of rosella flower extract gel on gingiva as the standard treatment of gingivitis after acrylic crown insertion. Material and Methods: This research type was pure experimental research using randomized design pre-and post-t-test with control group (the randomized pretest-posttest control group design). Clinical test (in vivo test) were done to determine the effect gel therapeutic containing rosella extract as therapy on standards gingivitis treatment in patients with artificial crown. Results: Antimicrobial test of Rosella flower extract on P. gingivalis and S. Sanguis bacteria showed that antimicrobial effectiveness of Rosella flower extract was found at concentration of 10%. Conclusion: 10% rosella gel extracts can be used as an alternative ingredients in standard gingival inflammation treatment due to artificial acrylic crown using.