The Changes in Bacterial Microbiome Associated with Immune Disorder in Allergic Respiratory Disease

Abstract

Allergic respiratory disease is a worldwide and increasingly prevalent health problem. Many researchers have identified complex changes in the microbiota of the respiratory and intestinal tracts in patients with allergic respiratory diseases. These affect immune response and influence the progression of disease. However, the diversity of bacterial changes in such cases make it difficult to identify a specific microorganism to target for adjustment. Recent research evidence suggests that common bacterial variations present in allergic respiratory disease are associated with immune disorders. This finding could lead to the discovery of potential therapeutic targets in cases of allergic respiratory disease. In this review, we summarize current knowledge of bacteria changes in cases of allergic respiratory disease, to identify changes commonly associated with immune disorders, and thus provide a theoretical basis for targeting therapies of allergic respiratory disease through effective modulation of key bacteria.

Role of Dietary Fiber and Energy Intake on Gut Microbiome in Vegans, Vegetarians, and Flexitarians in Comparison to Omnivores—Insights from the Nutritional Evaluation (NuEva) Study

“…Here, increased levels of Haemophilus are linked to mucosal inflammation [41]. Amongst genera such as Staphylococcus, Moraxella, and Pseudomonas, Haemophilus seems to promote pro-inflammatory Th2 and Th17 cytokines and correlate with higher levels of IgE [42]. Further investigation needs to be done to identify possible dietary factors that may influence the prevalence of Haemophilus as part of the gut microbiome and if this genus could be a negative biomarker in relation with high carbohydrate/fiber consumption.…”

Integrated Network Pharmacology and Gut Microbiota Analysis to Explore the Mechanism of Sijunzi Decoction Involved in Alleviating Airway Inflammation in a Mouse Model of Asthma

“…The proportion of Proteus in the intestinal flora of patients with asthma is increased and that of bifidobacteria and Bacteroides is decreased. The relative abundance of Veillonellaceae and Prevotellariceae in the intestinal flora of patients with severe asthma is higher [ 51 , 52 ], suggesting that the changes in intestinal flora diversity in patients with asthma are related to the incidence rate of asthma. Alterations in the intestinal flora can lead to exposure or deficiency of certain microorganisms in the body, resulting in abnormal metabolism of the flora activating inflammatory pathways.…”