The changes of glucose and lipid metabolism in overweight middle‐aged cynomolgus monkeys

Abstract

Overweight could result in impaired insulin sensitivity. The metabolic changes were more prominent in female overweight monkeys.

Somatometric measurements, and clinical chemistry and hematology parameters in Tibetan macaque (Macaca thibetana)

“…The waist circumference and WHR of females were higher than those of males in this study, which implied excessive abdominal body fat and potential insulin resistance in females. WHR had been found to be associated with HOMA‐IR in overweight middle‐aged cynomolgus monkeys . So, Tibetan macaques may be an ideal animal model for metabolic disease, such as obesity, metabolic syndrome, and diabetes mellitus.…”

A preliminary report on oral fat tolerance test in rhesus monkeys

“…In addition, obesity could also be induced in cynomolgus and rhesus monkeys through a long-term high fat and high fructose diet [5,6]. Abnormalities in lipid metabolism have been found in overweight or obese cynomolgus and rhesus monkeys in the fasting state [7,8]. Higher values of fasting Total cholesterol (TC) and low-density lipoprotein (LDL) have also been discovered in cynomolgus monkeys when feeding a high-sugar high-fat (HSHF) diet for 33 weeks [9].…”

Quality of hematology and clinical chemistry results in laboratory and zoo nonhuman primates: Effects of the preanalytical phase. A review

“…87,88 Effects of obesity modify results independent of the effects of test articles, and results with both obese and lean subjects may mask interindividual differences. 89 In obese cynomolgus macaques, there were increased concentrations of cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL), LDL, glucose in some cases, and insulin 90,91 ; in another study of obese cynomolgus macaques, obesity had a strong negative correlation with adiponectin and strong positive correlations with insulin, leptin, glucose, triglycerides, hemoglobin, hematocrit and mean corpuscular volume (MCV), with no or weak correlations with other routine hematology and biochemistry variables. 92,93 In obese rhesus macaques, plasma leptin concentration was approximately 3 times higher than in lean animals.…”