The changing face of GIST: implications for pathologists

Hemmings, Chris; Yip, Desmond

doi:10.1097/pat.0000000000000047

Cited by 11 publications

(5 citation statements)

References 64 publications

(41 reference statements)

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“…Além disso, segundo Hayes et al (24) , Yamamoto et al (25) and Dailey et al (26) , a definição do diagnóstico é imprescindível, devido ao comportamento distinto dessas neoplasias, o que pode (27) , a imunohistoquímica permite a identificação de doenças malignas e indiferenciadas a partir de marcadores que auxiliem na identificação da linhagem celular acometida, no entanto, deve ser associada à análise histopatológica e história clínica do paciente, conforme realizado no presente estudo. Caso a imuno-histoquímica não identifique a origem celular, análises mutacionais podem ser realizadas para a elucidação do diagnóstico (28) .…”

Section: Discussionunclassified

Diagnósticos histomorfológico e imunofenotípico de tumores estromais gastrointestinais e outros sarcomas que acometem o intestino de cães

Costa,

Sueiro,

Jark

et al. 2023

Ciênc. anim. bras.

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Resumo Tendo em vista a semelhança morfológica entre tumores estromais gastrointestinais (GIST) e outros sarcomas do intestino de cães, objetivou-se realizar o diagnóstico histomorfológico e imunoistoquímico desses tumores, associando raça, sexo e idade, localização e invasão tumoral. Foram avaliados 217 casos por histopatologia e incluídos 36 diagnosticados por imuno-histoquímica (24 GIST e 12 outros sarcomas intestinais). Cães sem raça definida foram os mais diagnosticados com GIST, principalmente fêmeas idosas (9,5±2,2 anos); nos demais sarcomas intestinais, mestiços e Dachshunds, machos e fêmeas, foram igualmente acometidos. O ceco foi o mais acometido pelos GISTs, com invasão tumoral das camadas intestinais em todos os casos. O intestino delgado foi o mais acometido pelos demais sarcomas intestinais, com invasão das camadas na maioria desses tumores. GISTs expressaram marcadores como CD117 e DOG-1, ao contrário de outros sarcomas intestinais. O GIST e outros sarcomas intestinais denotaram características histomorfológicas e imunofenotípicas semelhantes à histopatologia, justificando a associação da imuno-histoquímica para o diagnóstico definitivo.

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Section: Discussionunclassified

Diagnósticos histomorfológico e imunofenotípico de tumores estromais gastrointestinais e outros sarcomas que acometem o intestino de cães

Costa,

Sueiro,

Jark

et al. 2023

Ciênc. anim. bras.

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“…NF1-associated GISTs usually retain expression of succinate dehydrogenase. [4] Majority (about 80%) of gastric GISTs have low risk for malignancy. Duodenal GISTs are most often found in the second part of duodenum and about half of them have high risk for malignancy.…”

Section: Original Articlementioning

confidence: 99%

“…[3] GIST-affected patients have vague symptoms and mostly are discovered incidentally. [1,3,4] Most GISTs arise sporadically, but a small proportion arises with other tumours, (Carney triad) familial GIST syndrome and neurofibromatosis type 1 (NF1). [4] Stomach is the most common site of GIST (approximately 60-70%).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Morphologic Spectrum and Clinico-Pathological Correlation of Gastrointestinal Stromal Tumours: An Experience of Six Years at a Tertiary Care Hospital.

Qureshi

Tariq

Zafar

et al. 2016

J Cancer Allied Spec

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Objective: The objective of this study was to determine the morphologic spectrum and risk category of gastrointestinal stromal tumour (GIST) and compare with overall patient survival.Materials and Methods: It is a descriptive observational study. The study was carried at Shifa International Hospital, Islamabad. Duration of the study was from January 2009 to January 2015. A total of 31 patients with the diagnosis of GIST were included, irrespective of age and gender. Data were retrieved from laboratory information system. Results were analysed by statistical software, Statistical Package of the Social Sciences. Morphologic type, site of tumour, risk category and overall survival were determined and mean, standard deviation, frequencies and percentages were calculated for age site and risk category. Results: Of 31 patients, 21 (67.7%) were male and 10 (32.3%) were female. Site of tumour was as follows: Gastric 13 (41.9%), extra visceral 6 (19.4%), small intestine 9 (29.0%), rectum 2 (6.5%) and pancreas 1 (3.2%). According to risk categorisation, one was categorised as (3.2%) very low risk, 3 (9.7%) low risk, 5 (16.1%) intermediate risk and 22 (71%) high risk. Follow-up was available in 21 patients. 7 patients (22.5%) lost to follow-up. 8 (25%) had recurrence and 4 (12.9%) died. Conclusion: Majority of cases diagnosed at our centre were gastric in origin followed by small intestine, and as per risk categorisation, most were high risk. Patient survival with high-risk tumours was dismal. Key words: Gastrointestinal stromal tumour, immunohistochemistry, risk categorisation

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“…Most GISTs are sporadic in nature, with 80%–90% harbouring an exon 11 KIT mutation, approximately 10% have an exon 9 mutation and rare cases have exon 13 or exon 17 mutations 29. Exon 11 mutations, involving deletions of codons 550–560, are associated with more aggressive behaviour 30.…”

Section: The Role Of C-kit In Disease and Neoplasiamentioning

confidence: 99%

Gene of the month:KIT

Roberts

Govender

2015

J Clin Pathol

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Deranged pathway activation and KIT mutations occur in numerous solid and haematological malignancies, with gain-of-function mutations being the most common demonstrable abnormality. Through a complex series of interactions, activation of the KIT receptor tyrosine kinase leads to cell survival, evasion of apoptosis, angiogenesis, dysregulated cell cycle control and promotion of tumourigenesis. The KIT receptor tyrosine kinase is a well-studied therapeutic target in human malignancies. The KIT mutational status of a neoplasm plays an important role in predicting the response to targeted therapies. In this article we outline the structure, function and mutations of the KIT gene, its role in various neoplasms, therapeutic impacts and the role that these play in clinical patient outcome.

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The changing face of GIST: implications for pathologists

Cited by 11 publications

References 64 publications

Diagnósticos histomorfológico e imunofenotípico de tumores estromais gastrointestinais e outros sarcomas que acometem o intestino de cães

Diagnósticos histomorfológico e imunofenotípico de tumores estromais gastrointestinais e outros sarcomas que acometem o intestino de cães

Morphologic Spectrum and Clinico-Pathological Correlation of Gastrointestinal Stromal Tumours: An Experience of Six Years at a Tertiary Care Hospital.

Gene of the month:KIT

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