The Changing Face of Renal-Cell Carcinoma

Abstract

The present decade can be credited with the improved understanding of renal-cell carcinoma (RCC), its local and systemic management, and various controversies from diagnosis to types of various available interventions. The old paradigms and dogmas are no longer accepted as ''the best way'' without evidence, and many ''old'' principles are cautiously questioned. These notions have resulted in new knowledge, questions, arguments, and treatment options. This article will describe the ''changing face of RCC'' over the past several years and will briefly summarize the major changes and issues in the field of renal oncology. The discussed topics include improved molecular understanding of RCC, management of small renal masses, the safety and accuracy of renal mass biopsy, the emerging role of molecular imaging, the importance of maximal renal preservation, and the evolving role of laparoscopy, robotics, and ablation.

Noninvasive Fuhrman grading of clear cell renal cell carcinoma using computed tomography radiomic features and machine learning

“…In the recent years, several new non-invasive therapeutic methods for RCC have been developed, including radiofrequency ablation, cryoablation, and active surveillance (10). However, there lacks proper criterion for patient management with these non-invasive/minimally invasive treatment methods, and are often treated surgically post-diagnosis (11,12). Therefore, it is desirable to produce individualized treatment strategies, where radical approaches (e.g.…”