The characteristics of alpha-adrenoceptors mediating the renal nerve induced antinatriuresis and antidiuresis in hypertensive rats

Akpogomeh, Benjamin A.; Johns, Edward J.

doi:10.1097/00004872-199104000-00010

Cited by 6 publications

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“…The final study was undertaken in the 2K1C Goldblatt hypertensive rats and over the four week period of renal artery clipping the rats had developed a hypertension as indicated by the mean blood pressure of 160 mmHg, which is comparable to that observed in other studies with these hypertensive rats (Akpogomeh & Johns, 1991;Sattar & Johns, 1994;Davis & Johns, 1994). The renal functional data showed that although glomerular filtration rate was very similar in the clipped and non-clipped kidneys, water and sodium excretion was much higher in the non-clipped compared to the clipped kidney.…”

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confidence: 66%

The cardiovascular and renal functional responses to the 5‐HT_1A receptor agonist flesinoxan in two rat models of hypertension

Chamienia

Johns²

1996

British J Pharmacology

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4 Flesinoxan administration (30-1000 jg kg'-, i.v.) into 2K1C Goldblatt hypertensive rats caused a maximum decrease in blood pressure and heart rate (both P< 0.001) of 34 + 3 mmHg and 20 + 6 beats min-' and while renal blood flow and glomerular filtration rate were autoregulated, from 160 to 125 mmHg, there were dose-related decreases in urine volume and sodium excretion from the clipped and non-clipped kidneys of approximately 50-60% at the highest dose. 5 These findings suggest that in the stroke prone spontaneously hypertensive rat the renal nerves importantly control sodium and water reabsorption at the level of the tubules, whereas in 2K1C Goldblatt hypertensive rats, they play a minor role.

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Section: Discussionsupporting

confidence: 66%

The cardiovascular and renal functional responses to the 5‐HT_1A receptor agonist flesinoxan in two rat models of hypertension

Chamienia

Johns²

1996

British J Pharmacology

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Selective α1-adrenoreceptor blockers in the treatment of hypertension: Should we be using them more?

Ligueros

Unwin

Wilkins

1991

Clinical Autonomic Research

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It has become apparent in recent years that in the treatment of essential hypertension, reduction of blood pressure alone is not sufficient to reduce significantly the morbidity and mortality from ischaemic heart disease. Since the emergence of a multifactorial approach to the prevention of cardiovascular disease, the potential interaction between antihypertensive therapy and metabolic factors, such as control of blood glucose and lipid levels, has become an important consideration. Abnormal function of the sympathetic nervous system may contribute to both the initiation, or maintenance, of hypertension and the associated metabolic disturbances. The new generation of selective alpha 1-adrenoreceptor blockers, besides lowering blood pressure, appear to have favourable effects on lipid and glucose metabolism. The use of these drugs and their place in the treatment of hypertension are discussed.

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α1-Adrenoceptor subtypes mediating antinatriuresis in Wistar and stroke-prone spontaneously hypertensive rats

Sattar

Johns

1995

European Journal of Pharmacology

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The characteristics of alpha-adrenoceptors mediating the renal nerve induced antinatriuresis and antidiuresis in hypertensive rats

Cited by 6 publications

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The cardiovascular and renal functional responses to the 5‐HT_1A receptor agonist flesinoxan in two rat models of hypertension

The cardiovascular and renal functional responses to the 5‐HT_1A receptor agonist flesinoxan in two rat models of hypertension

Selective α1-adrenoreceptor blockers in the treatment of hypertension: Should we be using them more?

α1-Adrenoceptor subtypes mediating antinatriuresis in Wistar and stroke-prone spontaneously hypertensive rats

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The characteristics of alpha-adrenoceptors mediating the renal nerve induced antinatriuresis and antidiuresis in hypertensive rats

Cited by 6 publications

References 0 publications

The cardiovascular and renal functional responses to the 5‐HT1A receptor agonist flesinoxan in two rat models of hypertension

The cardiovascular and renal functional responses to the 5‐HT1A receptor agonist flesinoxan in two rat models of hypertension

Selective α1-adrenoreceptor blockers in the treatment of hypertension: Should we be using them more?

α1-Adrenoceptor subtypes mediating antinatriuresis in Wistar and stroke-prone spontaneously hypertensive rats

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The cardiovascular and renal functional responses to the 5‐HT_1A receptor agonist flesinoxan in two rat models of hypertension

The cardiovascular and renal functional responses to the 5‐HT_1A receptor agonist flesinoxan in two rat models of hypertension