The characteristics of lung cancer in Xuanwei County: A review of differentially expressed genes and noncoding RNAs on cell proliferation and migration

Li, Rong; Liu, Yan; Wang, Tiying; Tang, Jiadai; Xie, Lin; Yao, Zhihong; Li, Kechen; Liao, Yedan; Zhou, Ling; Geng, Zhenqin; Huang, Zeyong; Yang, Zuozhang; Han, Lei

doi:10.1016/j.biopha.2019.109312

Cited by 18 publications

(13 citation statements)

References 86 publications

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“…Retrospective studies have shown that a lifelong use of smoky coal is associated with a 36-and 99-fold increase in mortality in men and women, respectively, compared with smokeless coal use (5,6). Notably, lung cancer in Xuanwei has some remarkable characteristics, such as higher incidence in non-smoking females, diagnosis at a younger age, rapid tumour progression, multiple lung lesions, poor overall prognosis, and family aggregation (7). Overall, lung cancer patients in Xuanwei may present a distinct subgroup globally, leading researchers to consider whether epidemiological and clinicopathological peculiarities can be interpreted based on genomic features.…”

Section: Introductionmentioning

confidence: 99%

Next-Generation Sequencing Reveals High Uncommon EGFR Mutations and Tumour Mutation Burden in a Subgroup of Lung Cancer Patients

Guo¹,

Li²,

Liu

et al. 2021

Front. Oncol.

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Xuanwei County in Southwest China shows the highest incidence and mortality rate of lung cancer in China. Although studies have reported distinct clinical characteristics of patients from Xuanwei, the molecular features of these patients with non-small cell lung cancer (NSCLC) remain unclear. Here, we comprehensively characterised such cases using next-generation sequencing (NGS). Formalin-fixed, paraffin-embedded tumour samples from 146 patients from Xuanwei with NSCLC were collected for an NGS-based target panel assay; their features were compared with those of reference Chinese and The Cancer Genome Atlas (TCGA) cohorts. Uncommon EGFR mutations, defined as mutations other than L858R, exon 19del, exon 20ins, and T790M, were the predominant type of EGFR mutations in the Xuanwei cohort. Patients harbouring uncommon EGFR mutations were more likely to have a family history of cancer (p = 0.048). A higher frequency of KRAS mutations and lower frequency of rearrangement alterations were observed in the Xuanwei cohort (p < 0.001). Patients from Xuanwei showed a significantly higher tumour mutation burden than the reference Chinese and TCGA cohorts (p < 0.001). Our data indicates that patients from Xuanwei with NSCLC harbouring G719X/S768I co-mutations may benefit from treatment with EGFR-tyrosine kinase inhibitors. Our comprehensive molecular profiling revealed unique genomic features of patients from Xuanwei with NSCLC, highlighting the potential for improvement in targeted therapy and immunotherapy.

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Section: Introductionmentioning

confidence: 99%

Next-Generation Sequencing Reveals High Uncommon EGFR Mutations and Tumour Mutation Burden in a Subgroup of Lung Cancer Patients

Guo¹,

Li²,

Liu

et al. 2021

Front. Oncol.

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“…Numerous studies were done to elucidate the multiple mechanisms of Xuanwei and Gejiu lung cancer; however, there were currently no effective treatments for those local lung cancer patients, and the precise molecular mechanism involved remained largely unclear (9,13,49,(51)(52)(53)(54). Previous findings confirmed that microRNAs play critical roles in the development of Xuanwei and Gejiu lung cancer and might be diagnostic biomarkers (9,13,55). In the current study, we demonstrated for the first time the miR-34a function and the miR-34a-related regulatory mechanisms in the tumorigenesis and progression of lung cancer in Xuanwei and Gejiu Country, Yunnan Province, China.…”

Section: Discussionmentioning

confidence: 94%

“…Data and statistics about cancer incidence and mortality confirmed lung cancer was the top cancer for men and women in China, and especially in Xuanwei and Gejiu Country (1-3). Furthermore, epidemiological and etiological findings demonstrated that lung cancer in Xuanwei and Gejiu Country presented regional difference and professional specificity, which suggested that there might be unique genetic variations in the development of Xuanwei and Gejiu lung cancer (7)(8)(9). For example, mutations in MUC16 gene are observed in 50% of lung cancer patients residing in Xuanwei and dysregulation of MUC16 was involved in the progression of Xuanwei lung cancer (49,50).…”

Section: Discussionmentioning

confidence: 99%

“…Third, unlike other regions, the incidence of lung adenocarcinoma in nonsmoking women in Xuanwei Country was very high, one of the highest in the world (2,12). And the main clinical features of lung adenocarcinoma in Xuanwei Country were younger onset, high metastasis rate and insensitivity to conventional chemotherapy and radiotherapy (9). Although current epidemiological and etiological findings indicate that genetic variation might play an important role in tumorigenesis and progression of lung cancer in Gejiu and Xuanwei Country, there are few studies on unique genes in Gejiu and Xuanwei lung cancer initiation and progression.…”

Section: Introductionmentioning

confidence: 92%

“…Since the 1960s, lung cancer in Gejiu and Xuanwei Country has become increasingly attractive for many researchers, and numerous epidemiological and etiological studies have been performed. Previous etiological and epidemiological studies have confirmed that lung cancer in Gejiu and Xuanwei County has its own unique characteristics (2,(5)(6)(7)(8)(9). First, high incidence and mortality of lung cancer in the Gejiu Country are related with radon and mine dusts in the air of the workplace, and high incidence and mortality of lung cancer in Xuanwei County was related with PAHs and indoor coal-fired particle.…”

Section: Introductionmentioning

confidence: 95%

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The Association of microRNA-34a With High Incidence and Metastasis of Lung Cancer in Gejiu and Xuanwei Yunnan

et al. 2021

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The incidence and associated mortality of lung cancer in tin miners in Gejiu County and farmers in Xuanwei Country, Yunnan Province have been very high in the world. Current published literatures on the molecular mechanisms of lung cancer initiation and progression in Gejiu and Xuanwei County are still controversial. Studies confirmed that microRNA-34a (miR-34a) functioned as a vital tumor suppressor in tumorigenesis and progression. However, the role and precise mechanisms of miR-34a and its regulatory gene network in initiation and progression of lung cancer in Gejiu and Xuanwei County, Yunnan Province, have not been elucidated. In the current study, we first found that miR-34a was downregulated in Gejiu lung squamous carcinoma YTMLC-90, Xuanwei lung adenocarcinoma XWLC-05, and other non-small cell lung carcinoma (NSCLC) cell lines, and miR-34a overexpression inhibited cell proliferation, migration and invasion, as well as induced cell apoptosis in YTMLC-90 and XWLC-05 cells. Our findings revealed that miR-34a is critical and cannot be considered as the area-specific non-coding RNA in initiation and progression of lung cancer in Gejiu and Xuanwei County. Next we revealed that miR-34a overexpression suppressed lung cancer growth and metastasis partially via increasing PTEN but reducing CDK6 expression that might lead to subsequent inactivation of PI3K/AKT pathway. Furthermore, our findings demonstrated that YY1 functioned as a tumor suppressor gene in initiation and progression of lung cancer in Gejiu and Xuanwei County. In conclusion, our findings in the study confirmed that miR-34a overexpression could simultaneously suppress tumor growth and metastasis and play a vital role in tumorigenesis and progression of NSCLC via increasing PTEN and YY1 expression, but decreasing CDK6. Most interestingly, our findings also raised doubts about the current ideas about these area-specific diseases.

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Lappaconitine sulfate induces apoptosis and G0/G1 phase cell cycle arrest by PI3K/AKT signaling pathway in human non-small cell lung cancer A549 cells

Song

et al. 2020

Acta Histochemica

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The characteristics of lung cancer in Xuanwei County: A review of differentially expressed genes and noncoding RNAs on cell proliferation and migration

Cited by 18 publications

References 86 publications

Next-Generation Sequencing Reveals High Uncommon EGFR Mutations and Tumour Mutation Burden in a Subgroup of Lung Cancer Patients

Next-Generation Sequencing Reveals High Uncommon EGFR Mutations and Tumour Mutation Burden in a Subgroup of Lung Cancer Patients

The Association of microRNA-34a With High Incidence and Metastasis of Lung Cancer in Gejiu and Xuanwei Yunnan

Lappaconitine sulfate induces apoptosis and G0/G1 phase cell cycle arrest by PI3K/AKT signaling pathway in human non-small cell lung cancer A549 cells

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