The Characteristics of <scp>ABO</scp> Antibodies in Group <scp>O T</scp>hai Blood Donors

Khampanon, Kamontip; Chanprakop, Thanaporn; Sriwanitchrak, Pramote; Setthakarn, Manida; Oota, Sineenart; Nathalang, Oytip

doi:10.1002/jcla.21499

Cited by 19 publications

(23 citation statements)

References 22 publications

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“…Their study determined that there was an inverse relationship between titer and age in the male group O donors for both anti‐A and anti‐B IgM. Khampanon and colleagues tested 300 group O Thai donors (male and female) for IgG and IgM anti‐A and anti‐B titers through serial dilutions. Their study determined that anti‐B IgM titers decreased with age in both males and females.…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin M anti‐A and anti‐B titers in South Texas group O D+ male donors

Beddard¹,

Ngamsuntikul²,

Wafford³

et al. 2019

Transfusion

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BACKGROUND: The success of whole blood (WB) in damage control resuscitation on the battlefield has generated interest in its use for civilian trauma. Blood centers must maintain a committed donor pool with low isoagglutinin titers to provide this product. Information regarding isoagglutinin titers in different donor populations will help with targeted recruitment of these donors. STUDY DESIGN AND METHODS: Sequential O D+male donors with a history of two or more donations at a fixed site were tested for immunoglobulin (Ig)M anti-A and anti-B using a single titer cutoff of 256. Donors testing negative at this cutoff were considered "low titer" while positive donors were considered "high titer." Age and self-identified race/ethnicity were retrospectively obtained from the blood establishment computer system. Fisher's exact analysis was used for statistical analysis with a p value of less than 0.05 considered significant. RESULTS:Of 3274 donors, 426 tested as high titer, while 2848 tested as low titer. The data show an association of donor age and prevalence of high titers with older age groups showing a lower prevalence of high titers. In addition, different races/ethnicities have different prevalences of high titers with the Caucasian/white group showing a lower prevalence of high-titer donors versus the Hispanic and undeclared race groups. ABBREVIATION: WB = whole blood.From the 1 Medical Affairs, BioBridge Global, and the

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Section: Discussionmentioning

confidence: 99%

Immunoglobulin M anti‐A and anti‐B titers in South Texas group O D+ male donors

Beddard¹,

Ngamsuntikul²,

Wafford³

et al. 2019

Transfusion

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“…The researchers linked the high frequency of dangerous donors to environmental factors, differences in the composition of the intestinal microbiota, presence of intestinal parasites, outcomes of vaccination or exposure to other antigens. They also noted that the number of female donors had grown in recent years, which can justify the proportion of high-risk donors, as pregnancy is a factor that contributes to higher anti-A and anti-B hemagglutinins 20 . Note that the cut-off point adopted in this study was 64, that is less than that in most other studies, which explains, in part, the high number of dangerous donors 12 …”

Section: Discussionmentioning

confidence: 72%

“…They also noted that the number of female donors had grown in recent years, which can justify the proportion of high-risk donors, as pregnancy is a factor that contributes to higher anti-A and anti-B hemagglutinins. 20 Note that the cut-off point adopted in this study was 64, that is less than that in most other studies, which explains, in part, the high number of dangerous donors. 12 …”

Section: Discussionmentioning

confidence: 75%

Dangerous universal donors: the reality of the Hemocentro in Belo Horizonte, Minas Gerais

Godin

Souza

Schmidt

et al. 2016

Revista Brasileira de Hematologia e Hemoterapia

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BackgroundThe term dangerous universal blood donor refers to potential agglutination of the erythrocytes of non-O recipients due to plasma of an O blood group donor, which contains high titers of anti-A and/or anti-B hemagglutinins. Thus, prior titration of anti-A and anti-B hemagglutinins is recommended to prevent transfusion reactions.ObjectiveThe aim of this study was to estimate the frequency of dangerous universal donors in the blood bank of Belo Horizonte (Fundação Central de Imuno-Hematologia – Fundação Hemominas – Minas Gerais) by determining the titers of anti-A and anti-B hemagglutinins in O blood group donors.MethodA total of 400 O blood group donors were randomly selected, from March 2014 to January 2015. The titers of anti-A and anti-B hemagglutinins (IgM and IgG classes) were obtained using the tube titration technique. Dangerous donors were those whose titers of anti-A or anti-B IgM were ≥128 and/or the titers of anti-A or anti-B IgG were ≥256. Donors were characterized according to gender, age and ethnicity. The hemagglutinins were characterized by specificity (anti-A and anti-B) and antibody class (IgG and IgM).ResultsAlmost one-third (30.5%) of the O blood group donors were universal dangerous. The frequency among women was higher than that of men (p-value = 0.019; odds ratio: 1.66; 95% confidence interval: 1.08–2.56) and among young donors (18–29 years old) it was higher than for donors between 49 and 59 years old (p-value = 0.015; odds ratio: 3.05; 95% confidence interval: 1.22–7.69). There was no significant association between dangerous universal donors and ethnicity, agglutinin specificity or antibody class.ConclusionEspecially platelet concentrates obtained by apheresis (that contain a substantial volume of plasma), coming from dangerous universal donors should be transfused in isogroup recipients whenever possible in order to prevent the occurrence of transfusion reactions.

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“…It is known from the literature that approximately 60% of isohemagglutinins are capable of causing RBC lysis and, as a consequence, the percentage of platelet units labeled as unsuitable for transfusion after the implementation of this methodology in our service was similar to other publications at 65%. 15 This negatively affected platelet inventory management and caused delays in the transfusion process. Moreover, an extra blood sample had to be collected from donors, due to the necessity of performing QHT using sera instead of plasma, which is the material commonly available in the immunohematology laboratory.…”

Section: Discussionmentioning

confidence: 99%

Prophylactic strategies for acute hemolysis secondary to plasma-incompatible platelet transfusions: correlation between qualitative hemolysin test and isohemagglutinin titration

Landim

Gomes

Zeza

et al. 2015

Revista Brasileira de Hematologia e Hemoterapia

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ObjectiveBrazilian legislation has recently suggested the use of the qualitative hemolysin test instead of isohemagglutinin titers as prophylaxis for acute hemolysis related to plasma-incompatible platelet transfusions. The efficacy of this test in preventing hemolytic reactions has never been evaluated while isohemagglutinin titers have been extensively studied. The main objective of this study was to evaluate the correlation between the results of these two tests. The impact of each type of prophylaxis on the platelet inventory management and the ability of the qualitative hemolysin test to prevent red cell sensitization after the transfusion of incompatible units were also studied.MethodsA total of 246 donor blood samples were evaluated using both isohemagglutinin titers and the qualitative hemolysin test, and the results were statistically compared. Subsequently, 600 platelet units were tested using the hemolysin assay and the percentage of units unsuitable for transfusion was compared to historical data using isohemagglutinin titers (cut-off: 100). Moreover, ten patients who received units with minor ABO incompatibilities that were negative for hemolysis according to the qualitative hemolysin test were evaluated regarding the development of hemolysis and red cell sensitization (anti-A or anti-B).ResultsIsohemagglutinin titration and the results of qualitative hemolysin test did not correlate. The routine implementation of the qualitative hemolysin test significantly increased the percentage of platelet units found unsuitable for transfusions (15–65%; p-value <0.001). Furthermore the qualitative hemolysin test did not prevent red blood cell sensitization in a small exploratory analysis.ConclusionQualitative hemolysin test results do not correlate to those of isohemagglutinin titers and its implementation as the prophylaxis of choice for hemolysis associated with plasma-incompatible platelet transfusions lacks clinical support of safety and significantly affects platelet inventory management.

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The Characteristics of ABO Antibodies in Group O Thai Blood Donors

Cited by 19 publications

References 22 publications

Immunoglobulin M anti‐A and anti‐B titers in South Texas group O D+ male donors

Immunoglobulin M anti‐A and anti‐B titers in South Texas group O D+ male donors

Dangerous universal donors: the reality of the Hemocentro in Belo Horizonte, Minas Gerais

Prophylactic strategies for acute hemolysis secondary to plasma-incompatible platelet transfusions: correlation between qualitative hemolysin test and isohemagglutinin titration

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