The characterization of TBEV of European subtype circulating in Siberia, Russia

Козлова, И. В.; Демина, Т. В.; Tkachev, Sergey; Savinova, Yu. S.; Дорощенко, Е. К.; Лисак, О. В.; Dzhioev, Yu. P.; Suntsova, O. V.; Верхозина, М. М.; Paramonov, A. I.; Tikunova, Nina; Злобин, В. И.; Růžek, Daniel

doi:10.31631/2073-3046-2016-15-6-30-40

Cited by 5 publications

(3 citation statements)

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“…Число привитых лиц среди заболевших КЭ в Российской Федерации составляло в 2012 г. 3,9% 12 , в 2018 г. -1,5% [3].…”

Section: экспериментальные исследования эффективности специфической профилактики против различных генетических типов вируса клещевого энцunclassified

“…Показано, что на данной территории циркулируют штаммы дальневосточного подтипа, которые подразделяются на три кластера: Sofjin-, Senzhang-, Shkotovo-подобные штаммы [11]. Ареалом циркуляции европейского генотипа ВКЭ (генотип 2) является Центральная и Северная Европа [8], европейская территория России, Урал, Восточная и Западная Сибирь [7,8,12,13]. Сибирский подтип ВКЭ выявляется в европейской части России (Ярославская, Костромская, Вологодская области) [13][14][15], на Урале (Курганская, Свердловская, Челябинская области) [15][16][17], в Восточной (Иркутская, Читинская области, Красноярский край, Республика Хакасия) и Западной Сибири (Кемеровская область) [15,16,18,19].…”

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“…наук. Челябинск; 2015 12. Эпидемиологическая ситуация и прогноз заболеваемости клещевым вирусным энцефалитом в Российской Федерации на 2012 год.…”

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Effectiveness of Specific Prevention of Tick-Borne Encephalitis

Щербинина¹,

Бархалева²,

Дорохова³

et al. 2020

Biopreparaty. Profilaktika, diagnostika, lechenie

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Vaccination remains the only way to prevent tick-borne encephalitis (TBE). All TBE vaccines are based on strains of the Far Eastern and European subtypes of TBE virus. Currently, the Siberian subtype of the virus, which differs from the vaccine strains, accounts for 80–100% of the genetic population of TBE virus in most of Russia. The proportion of TBE vaccinated patients among those infected was different from year to year in Russia, e.g. 3.9% in 2012 and 1.5% in 2018, there were also some fatal cases registered among vaccinated patients. In this regard, evaluation of the effectiveness of vaccination against various genetic subtypes of TBE is a promising area of research. The purpose of this study was to summarise the results of studies investigating effectiveness of specific prevention of TBE as regards various genetic subtypes of the virus. The paper analyses data on the effectiveness of TBE vaccination in experimental settings and in real life. It was demonstrated that the use of vaccines for prevention of TBE is effective, provided the vaccination coverage is not less than 80%. The paper cites the data from a long-term study of the stability and protective activity of vaccine immunity against TBE virus strains isolated in highly endemic territories. It was established that TBE vaccines have high immunogenic activity and contribute to the production of stable protective antibodies against the strains of the three genetic subtypes of the virus. Protective efficacy of vaccination depends on the number of vaccinations received, the vaccination scheme, gender and age of those vaccinated. The paper concludes by saying that further studies are needed to assess TBE vaccine efficacy in order to improve vaccination tactics, to better understand causes of morbidity and mortality among vaccinated individuals.

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“…Число привитых лиц среди заболевших КЭ в Российской Федерации составляло в 2012 г. 3,9% 12 , в 2018 г. -1,5% [3].…”

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Effectiveness of Specific Prevention of Tick-Borne Encephalitis

Щербинина¹,

Бархалева²,

Дорохова³

et al. 2020

Biopreparaty. Profilaktika, diagnostika, lechenie

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European Subtype Tick-Borne Encephalitis Virus Emergence in South Korea (2005 – 2014) Can Be Associated With Human Activity

Kovalev

2024

Preprint

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Tick-borne encephalitis virus (TBEV) is the etiological agent of tick-borne encephalitis. TBEV is maintained in nature by the ixodid ticks Ixodes ricinus and I. persulcatus, which are its hosts and main vectors. The classification distinguishes three TBEV subtypes: Far Eastern, European (TBEV-Eu) and Siberian. Each subtype is characterized by its own range, reflected in its name. Nevertheless, numerous findings of TBEV subtypes in non-endemic areas have been reported. This phenomenon may be the result of virus introduction due to natural causes such as bird and mammal migrations. Detection of TBEV-Eu in South Korea in 2005 and in Siberia in the second half of the 20th century are significantly different from other cases of virus introduction. This paper presents the results of a comprehensive study including phylogenetic analysis, clusteron approach, establishing specificity of viral population dynamics, etc. The age of viral populations and the probable time of their emergence in non-endemic regions were determined. Using the example of TBEV-Eu in South Korea, we conclude that there is negative population dynamics of the virus after its introduction. This conclusion, in conjunction with several other features, indicates that human activity played a pivotal role in the TBEV-Eu introduction into South Korea and Siberia.

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