The chemical composition of hexane extract from bark of<b><i>Juniperus brevifolia</i></b>

Seca, Ana M. L.; Silva, Artur M. S.

doi:10.1080/14786410701654602

Cited by 13 publications

(10 citation statements)

References 35 publications

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“…The chemical composition of J. brevifolia essential oils has been reported by Adams [10] and Da Silva [11]. The GC-MS analysis of the hexane extract from the bark of this species showed essentially abietane-type diterpenoids [12]. We report herein the cytotoxic and antimicrobial activities of extracts from J. brevifolia and the isolation of compounds from the dichloromethane extract of the leaves, together with the cytotoxic activity of five of these compounds against HeLa and Vero cells.…”

Section: Absupporting

confidence: 56%

Cytotoxic Activity of Diterpenes and Extracts ofJuniperus brevifolia

et al. 2008

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The hexane, dichloromethane, acetone and ethanol extracts of the leaves, bark and wood of Juniperus brevifolia were subjected to screening against human tumour cells lines from the cervix (HeLa) and larynx (Hep-2) in two different stages of the cell cycle. The dichloromethane and the chloroform-soluble portions of the acetone extracts of the leaves were active against both tumour cell lines. Chemical investigation of one of the most active extracts (dichloromethane extract from leaves) by preparative chromatography afforded compounds 1-10. Among these, compounds 1-3 were isolated for the first time from the Juniperus genus (18-hydroxyferruginol, 6,7-dehydrototarol and 7alpha-hydroxytotarol) while 4 and 5 are rare as natural products corresponding to (E)- and (Z)-isomers of 8alpha-hydroxy-labda-13(16),14-dien-19-yl-coumarate, respectively. The structures of all compounds were established based on various spectral data. The cytotoxic activity was evaluated for the first time for compounds 1-5 against HeLa and Vero cell lines in lag and log phases of growth. Compound 5 was shown to be active and selective to HeLa in the log phase.

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Section: Absupporting

confidence: 56%

Cytotoxic Activity of Diterpenes and Extracts ofJuniperus brevifolia

et al. 2008

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“…Chemical characterization of n-hexane fraction (Green et al, 2011) has been reported to contain non polar compounds (Ahmad et al, 2011). Different types of terpenoids, fatty acids and sterols have been reported from the hexane extracts of botanicals (Seca and Silva, 2008). Antimicrobial activity of terpenoids (Ulubelen et al, 2003), fatty acids (Skalicka-Woźniak et al, 2010), volatile oils (Dorman and Deans, 2000) and sterols (Zhao et al, 2005) has been investigated.…”

Section: Discussionmentioning

confidence: 99%

In vitro Antibacterial Activity of n-Hexane Fraction of Methanolic Extract of Alstonia scholaris L. R.Br. Stem Bark against Some Multidrug Resistant Human Pathogenic Bacteria

Mukherjee

2012

EJMP

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Plants are a source of wide range of bioactive molecules. Alstonia scholaris, a tree species of Apocynaceae family is being reported as a well known herbal remedy of various diseases. In the present investigation, n-hexane fraction of crude methanolic extract of Alstonia scholaris Linn. R.Br. stem bark was evaluated for antibacterial activity using four human pathogenic multi-drug resistance bacterial strains Enterobacteriaceae bacterium IK1_01, Shigella dysentery, Enterobacter cloacae and Serratia marcescens. Antibiotic susceptibility tests were also performed to evaluate the multi-drug resistance patterns of these strains. All the strains showed multi-drug resistance against several commercially available antibiotics. The n-hexane fraction showed significant inhibitory activities against all the strains by agar-diffusion assay. The n-hexane fraction of crude methanolic extract of stem of A. scholaris showed MICs of 5.5 mg/ml, 5 mg/ml, <5.5 mg/ml and 8 mg/ml, and induced a maximum of 85.7%, 95.6%, 89.3% and 94.4% growth inhibition against E. bacterium IK1_01, S. dysentery, E. cloacae and S. marcescens, respectively.

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“…J. conferta Parl.) and Juniperus formosana Hayata [ 12 , 13 , 16 , 54 , 55 ]. Sugiol presents hepatoprotective [ 51 ] and antioxidant properties [ 56 ].…”

Section: Bioactive Secondary Metabolites From Juniperus mentioning

confidence: 99%

“…[ 12 , 13 ]. It is the most abundant compound in the hexane extract of J. brevifolia bark (11 mg of compound by 100 mg of extract) [ 54 ], being also found in species from other genus [ 63 ]. This compound seems to be a good bet towards new interesting active drugs development since it displays a range of interesting bioactivities such as antibacterial [ 64 , 65 , 66 ], antimycobacterial [ 38 ], antileishmanial [ 36 ], antimalarial [ 67 , 68 ], antistaphylococcal activity caused by efflux inhibitory properties [ 69 ], as well as nematicidal activity and antifouling attributes [ 36 ].…”

Section: Bioactive Secondary Metabolites From Juniperus mentioning

confidence: 99%

The Current Status of the Pharmaceutical Potential of Juniperus L. Metabolites

Tavares

Seca

2018

Medicines

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Background: Plants and their derived natural compounds possess various biological and therapeutic properties, which turns them into an increasing topic of interest and research. Juniperus genus is diverse in species, with several traditional medicines reported, and rich in natural compounds with potential for development of new drugs. Methods: The research for this review were based in the Scopus and Web of Science databases using terms combining Juniperus, secondary metabolites names, and biological activities. This is not an exhaustive review of Juniperus compounds with biological activities, but rather a critical selection taking into account the following criteria: (i) studies involving the most recent methodologies for quantitative evaluation of biological activities; and (ii) the compounds with the highest number of studies published in the last four years. Results: From Juniperus species, several diterpenes, flavonoids, and one lignan were emphasized taking into account their level of activity against several targets. Antitumor activity is by far the most studied, being followed by antibacterial and antiviral activities. Deoxypodophyllotoxin and one dehydroabietic acid derivative appears to be the most promising lead compounds. Conclusions: This review demonstrates the Juniperus species value as a source of secondary metabolites with relevant pharmaceutical potential.

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The chemical composition of hexane extract from bark ofJuniperus brevifolia

Cited by 13 publications

References 35 publications

Cytotoxic Activity of Diterpenes and Extracts ofJuniperus brevifolia

Cytotoxic Activity of Diterpenes and Extracts ofJuniperus brevifolia

In vitro Antibacterial Activity of n-Hexane Fraction of Methanolic Extract of Alstonia scholaris L. R.Br. Stem Bark against Some Multidrug Resistant Human Pathogenic Bacteria

The Current Status of the Pharmaceutical Potential of Juniperus L. Metabolites

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