The chemistry and toxicology of some venomous pelagic coelenterates

Investigation of the Biochemical and Histological Changes Induced by Zearalenone Mycotoxin on Liver in Male Mice and the Protective Role of Crude Venom Extracted from Jellyfish <i>Cassiopea Andromeda</i>

“…Abdel-Rehim [13] proved a protective effect of this crude venom in the cases of gastric ulceration evoked by indomethacin. The protective role of crude venom may be due to its content of bradykinin [38] which decreases the liver damage through reducing hepatocellular apoptosis [39]. In conclusion, this work confirmed that ZEN caused an alterations in the liver.…”

“…Regarding the group which pretreated with crude venom of Jellyfish twenty 24 hours prior to administration of ZEN twice a week for two weeks, the results showed an improvement in liver enzymes, alphafetoprotein and antioxidants concentrations. The coelenterata toxins contain bradykinin and related polypeptides which have a kinin like action [38]. The extracted crude venom from Jellyfish Cassiopea andromeda has been found to activate the liver cells by increasing the metabolic rate [12].…”

Effect of Jelly Fish Crude Venom on Liver, Thyroid and Harderian Glands of Female Mice

“…This means that the venom do not enhance lipid peroxidation. In addition significant elevation of total thiols, G-St-SOD and CAT activities in liver tissues of the groups treated with this toxin compared to the controls may be due to bradykinin in the venom that Burnett and Calton (1977) reported that the coelenterata toxins contain bradykinin related polypeptides which have a kinin like action. The possibility of using this crude venom extract from jelly fish (Eutoizina iizdicans) for elevations of T3 and T4 serum level in patients suffering from hypothyrodism may be explored.…”

“…This may be due to the effect of bradykinin in the jelly fish crude venom through the activation of prostaglandin synthesis which in turn stimulated the secretion of catecholamines (Stroev, 1989) which consequently stimulates the synthesis of thyroid secretion (Ganong, 1995). On the other hand, Burnett and Calton (1977) reported that bradykinin and related polypeptides are frequently found to be present in coelenterate toxins that have a kinin-like action. I t is also accepted that the activation of prostaglandins synthesis via the effect of bradykinin in the Jelly fish crude venom enhanced the sensibility of nervous system (Stroev, 1989) which stimulated the secretion of thyroid gland (Babsky et al, 1989).…”

“…The coelenterate toxins have been found to contain bradykinin and related polypeptides which have a kinin-like action (Burnett and Calton, 1977). Kinins are polypeptides of great biological importance acting as tissue hormones at the cellular level (Schill et al, 1982).…”