The Chemistry of Hydrazonates

Abstract

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Functionalized formazans: A review on recent progress in their pharmacological activities

“…In contrast to these comprehensive literature reports on the chemistry of formazans, there has been no survey of their biological activities hitherto although they have been found to possess wide spectrum of biological activities such as antiviral, antimicrobial, anti-inflammatory, antifungal, anticancer, anti HIV. Based on these findings and in continuation of our studies of the chemistry of both 3-chloro-1, 5-diarylformazans 2 [17–21] and the related hydrazonoyl halides 3 [22–35] ( Chart 1 ), it was thought necessary to present this review. Our objective is to shed light on the recent developments in biological activities of various functionalized formazans 1 ( Chart 1 ).…”

Utility of N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides as precursors for synthesis of new functionalized 1,3,4-thiadiazoles with potential antimicrobial activity

“…The chemistry of hydrazonoyl halides of the general formula, R—C(X) NNHR’, 1 , has attracted the interest of many research groups since their discovery in 1882 [1] . Their reactions with various reagents and their applications in synthesis of various heterocyclic compounds have been extensively reviewed by Shawali and/or his colleagues [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] and others [15] , [16] . A survey of literature reveals the presence of two contradicting reports [17] , [18] , [19] .…”

1,3,4-Thiadiazoles of pharmacological interest: Recent trends in their synthesis via tandem 1,3-dipolar cycloaddition: Review

“…This strategy proved useful and convenient for synthesis of various functionalized 1,3,4-thiadiazole derivatives D ( Scheme 1 ). Such a target has not been covered hitherto in the foregoing review articles surveying the chemistry of both 1,3,4-thiadiazoles [1–11] and nitrilimines as well as their precursors [12–24] .…”