The Chemopharmacological Approach to the Addiction Problem

Eddy, Nathan B.

doi:10.2307/4591901

Cited by 5 publications

(9 citation statements)

References 11 publications

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“…Another pathway pursued from 1952 onward was May's work building upon incomplete morphine molecules, which led to the production of phenylmorphans and benzomorphans (p. 676 in Ref. 40) 39,40 . By the mid‐1960s, the Committee's efforts to find a “chemopharmacological approach to the addiction problem” were focused on the narcotic antagonists 40 …”

Section: The Mid‐20th Century Project To Develop Narcotic Antagonistsmentioning

confidence: 99%

“…40) 39,40 . By the mid‐1960s, the Committee's efforts to find a “chemopharmacological approach to the addiction problem” were focused on the narcotic antagonists 40 …”

Section: The Mid‐20th Century Project To Develop Narcotic Antagonistsmentioning

confidence: 99%

“…Aware that heroin addiction could not be regarded solely as iatrogenic, the Committee did not think that a new medicine could effectively treat nonmedical addiction; rather, it focused on preventing potent new addictive compounds from being marketed. CDAN's relevant historical touchstone was the “heroin mistake” stemming from initial claims that heroin was a “nonaddictive” alternative to morphine for analgesia (p. 673) 40 . The “solution” to the heroin problem had been framed as an alternative analgesic that would displace the need for opium production.…”

Section: The Mid‐20th Century Project To Develop Narcotic Antagonistsmentioning

confidence: 99%

“…Without the need for morphine or codeine (work was underway to replace codeine as an antitussive), the global opium supply could be controlled. However, by the 1960s, the Committee understood that its “chemical‐pharmacological‐clinical program” was founded upon an erroneous hypothesis concerning the potential ease of dissociating the analgesic effects of morphine from the dependence‐producing and respiratory‐depressing effects (p. 674) 40 . The Committee turned toward narcotic antagonists upon the suggestion of Andrew Keats, hoping that this class of drugs would be clinically useful as analgesics 41 …”

Section: The Mid‐20th Century Project To Develop Narcotic Antagonistsmentioning

confidence: 99%

“…Recognizing that if even one of the new antagonists proved a sufficiently powerful analgesic without undue side effects, Eddy noted that it would still not “solve the addiction problem overnight (p. 679) 40 . Social and economic factors, he indicated, were paramount: “We shall still have the opium‐producing countries.…”

Section: The Mid‐20th Century Project To Develop Narcotic Antagonistsmentioning

confidence: 99%

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The history of the development of buprenorphine as an addiction therapeutic

Campbell

Lovell

2012

Annals of the New York Academy of Sciences

120

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This paper traces the early 21st century success of the agonist-antagonist buprenorphine and the combination drug buprenorphine with naloxone within the broader quest to develop addiction therapeutics that began in the 1920s as the search for a nonaddictive analgesic. Drawing on archival research, document analysis, and interviews with contemporary actors, this paper situates the social organization of laboratory-based and clinical research within the domestic and international confluence of several issues, including research ethics, drug regulation, public attitudes, tensions around definitions of drug addiction, and the evolving roles of the pharmaceutical industry. The fervor that drove the champions of buprenorphine must be understood in relation to (1) the material work of research and pharmaceutical manufacturing; (2) the symbolic role of buprenorphine as a solution to numerous problems with addiction treatment evident by the mid-1970s; the destigmatization and individualization of addicts as patients; and (3) the complex configurations of public and private partnerships.

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Section: The Mid‐20th Century Project To Develop Narcotic Antagonistsmentioning

confidence: 99%

“…40) 39,40 . By the mid‐1960s, the Committee's efforts to find a “chemopharmacological approach to the addiction problem” were focused on the narcotic antagonists 40 …”

Section: The Mid‐20th Century Project To Develop Narcotic Antagonistsmentioning

confidence: 99%

Section: The Mid‐20th Century Project To Develop Narcotic Antagonistsmentioning

confidence: 99%

Section: The Mid‐20th Century Project To Develop Narcotic Antagonistsmentioning

confidence: 99%

Section: The Mid‐20th Century Project To Develop Narcotic Antagonistsmentioning

confidence: 99%

See 3 more Smart Citations