2019
DOI: 10.15171/apb.2019.025
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The Chemopreventive Activity of Indonesia Medicinal Plants Targeting on Hallmarks of Cancer

Abstract: Cancer remains a complex disease with increasing global mortality and morbidity. Numerous theories have been established to understand the biological mechanism underlying cancer. One of the most renowned frameworks is the hallmark of cancer proposed by Hanahan and Weinberg that covers ten eminent characteristics of cancer: (i) genome instability and mutation, (ii) sustaining proliferative signaling, (iii) evading growth suppressor, (iv) enabling replicative immortality, (v) resisting cell death, (vi) inducing … Show more

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Cited by 19 publications
(15 citation statements)
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“…For additional, brazilin and brazillein from Caesalpinia sappan as well as Acetoxychavicol Acetate (ACA) and galangin from Alpinia galanga also showed antiviral activities in comparison with the rest selected compounds (Da'i, et. al., 2019;Meiyanto and Larasati, 2019). We cautiously selected certain targets to predict the anti-SARS-CoV-2 activity from each compound.…”
Section: Resultsmentioning
confidence: 99%
“…For additional, brazilin and brazillein from Caesalpinia sappan as well as Acetoxychavicol Acetate (ACA) and galangin from Alpinia galanga also showed antiviral activities in comparison with the rest selected compounds (Da'i, et. al., 2019;Meiyanto and Larasati, 2019). We cautiously selected certain targets to predict the anti-SARS-CoV-2 activity from each compound.…”
Section: Resultsmentioning
confidence: 99%
“…As a result, cancer cells carry out different platforms in energetic metabolism for their survival. This unique platform of cancer metabolism is an interesting focus on the development of anticancer and anti-ageing, especially focusing on ROS metabolism (Meiyanto and Larasati, 2019;Davalli et al, 2016). Some chemotherapeutic agents target ROS metabolisms, such as doxorubicin (Dox) and cisplatin (Yang et al, 2018).…”
Section: Introductionmentioning
confidence: 99%
“…We used several representative compounds of each plant which are known to have pharmacological benefits (Figure 1). These plants are also believed to contribute for health and immune system among Asian people in relation to those of the active constituents (Meiyanto & Larasati, 2019). We used molecular docking with 3 target receptors; SARS-CoV-2 protease (PDB:6LU7), Spike glycoprotein-RBD (PDB:6LXT), and PD-ACE2 (PDB:6VW1); that are believed to contribute in virus infection in comparation with the respected known ligand or drugs as references.…”
Section: Resultsmentioning
confidence: 99%
“…Noted for Curcuma sp. and sappan wood which are the main ingredients of most Indonesian traditional medicine "jamu" formulas, it is commonly believed to contribute in maintaining health condition due to its antioxidant activities of their constituents, such as curcumin in curcuma rhizome and brazilin in sappan wood (Meiyanto & Larasati, 2019). People usually consume these herbs in various drinking herbal formulas.…”
Section: Resultsmentioning
confidence: 99%