The chemotherapeutic potential of doxorubicin-loaded PEG-b-PLGA nanopolymersomes in mouse breast cancer model

Alibolandi, Mona; Sadeghi, Fatemeh; Abnous, Khalil; Atyabi, Fatemeh; Ramezani, Mohammad; Hadizadeh, Farzin

doi:10.1016/j.ejpb.2015.07.005

Cited by 82 publications

(31 citation statements)

References 50 publications

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“…[35] However, ac omparison of the IC 50 value of the DOX-loaded BAB 3 micelles with other potentiald rug carriers ystems, such as nanopolymersomes, shows af our-fold higher cytotoxicity for DOX-loaded BAB 3 micelles combinedw ith superior biocompatibility. [1] Hence, the DOX-loaded micelles showg ood apoptosis inductiona ctivity in HeLa cells. Consequently the designed BAB 3 micelles are potent candidates for an ovel pH-controlled drugdelivery system with sustained releaseproperties.…”

Section: Intracellular Dox Release and Antitumor Activitymentioning

confidence: 97%

“…The treatment of canceri sg enerally attempted by surgical removal of the affected tissuei nc ombination with radiation and chemotherapy.T reatment with chemotherapeutic agents, in particular, is often accompanied by undesirable severe side effects, such as the developmento f drug resistance and severe cardiact oxicity,a so bserved for doxorubicin (DOX) baseda nticancer treatments. [1] In general, these systemically administered therapeutic agents suffer from numerousi ssues, for example, hydrophobicity,i nefficient distribution, systemict oxicity,a nd low targeting capability.I nt urn, this decreases the efficiencyo ft hese treatments and puts extra strain on the patient by also affectingh ealthy tissue. [2] Fundamental problems associated with drug administration, including poor selectivity between malignant and innoxious cells, difficulties in adjusting drug dosages, andvarious biological hurdles,c an be addressed by nanomedicine.…”

Section: Introductionmentioning

confidence: 99%

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Next Generation Multiresponsive Nanocarriers for Targeted Drug Delivery to Cancer Cells

Altenbuchner

Werz

Schöppner

et al. 2016

Chemistry A European J

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C-H bond activation of 2-methoxyethylamino-bis(phenolate)-yttrium catalysts allowed the synthesis of BAB block copolymers comprised of 2-vinylpyridine (2VP; monomer A) and diethylvinylphosphonate (DEVP; monomer B) as the A and B blocks, respectively, by rare-earth-metal-mediated group-transfer polymerization (REM-GTP). The inherent multi-stimuli-responsive character and drug-loading and -release capabilities were observed to be dependent on the chain length and monomer ratios. Cytotoxicity assays revealed the biocompatibility and nontoxic nature of the obtained micelles toward ovarian cancer (HeLa) cells. The BAB block copolymers effectively encapsulated, transported, and released doxorubicin (DOX) within HeLa cells. REM-GTP enables access to previously unattainable vinylphosphonate copolymer structures, and thereby unlocks their full potential as nanocarriers for stimuli-responsive drug delivery in HeLa cells. The self-evident consequence is the application of these new micelles as potent drug-delivery vehicles with reduced side effects in future cancer therapies.

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Section: Intracellular Dox Release and Antitumor Activitymentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Next Generation Multiresponsive Nanocarriers for Targeted Drug Delivery to Cancer Cells

Altenbuchner

Werz

Schöppner

et al. 2016

Chemistry A European J

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“…(a), approximately 25% of PeaT1 protein can be released from P@NPs within the first 24 h in PBS medium, which were followed by continuous slow release behaviors in the following 7 days. The rapid release in the first several hours was related to protein absorbed/encapsulated on or near the nanoparticle surfaces . The sustained release indicated that release was dependent on diffusion and/or matrix erosion …”

Section: Resultsmentioning

confidence: 99%

“…The rapid release in the first several hours was related to protein absorbed/encapsulated on or near the nanoparticle surfaces. 25 The sustained release indicated that release was dependent on diffusion and/or matrix erosion. 26…”

Section: In Vitro Release Of P@npsmentioning

confidence: 99%

Enhanced plant growth promoting role of mPEG‐PLGA‐based nanoparticles as an activator protein PeaT1 carrier in wheat (Triticum aestivum L.)

Gao

Qin

Guo

et al. 2018

J of Chemical Tech & Biotech

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BACKGROUND Developing new types of bioproducts using innovative nanotechnology is one of the potentially effective options for enhancing agricultural production and reducing environmental agrochemical pollution. As a bioagent derived from fungi, activator protein can promote growth and control diseases by activating the plant immune system. Meanwhile, the nanocarrier can protect the protein within and prolong its efficiency through controlled release. RESULTS In our study, a new kind of plant nano‐activator was developed by encapsulating an activator protein PeaT1 using a polymer nanoparticle constructed with monomethoxy‐poly (ethylene glycol)‐poly (lactide‐co‐glycolide) (mPEG‐PLGA). The nanoparticles were spherical with diameter about 200 nm. Morphological and physiological parameters of wheat seedlings, including seed vigor index, root vitality, chlorophyll content and photosynthetic parameters, increased after treatment with the nano‐activator. Further observation under the confocal laser microscope showed a more effective intake of the nano‐activator protein. CONCLUSION The results showed that the nano‐activators are effective in enhancing wheat growth. This novel agent provides a promising way to improve crop production in an environmentally friendly manner. © 2018 Society of Chemical Industry

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“…The results for the free DOX group could be related to the previously reported toxicities that cause weight loss in mice, such as cardiotoxicity, neurotoxicity and nephrotoxicity. [45][46][47] Unlike the control and free DOX groups, the enhanced anticancer effects and reduced toxicities from application of the nGO@DOX-cPEG flakes (Supplementary Figure S8) led to accumulation and efficient delivery of DOX to tumor sites, which may be due to the sustained release and prolonged circulation in the bloodstream and the enhanced permeation and retention effect. 47,48 In addition, histopathological and immunohistochemical analyses were performed on the tumor masses to determine the expression levels of caspase-3, PARP, CD31 and Ki-67 (Figure 7c; Supplementary Table S2).…”

Section: Resultsmentioning

confidence: 99%

Easy on-demand self-assembly of lateral nanodimensional hybrid graphene oxide flakes for near-infrared-induced chemothermal therapy

Thapa

Byeon

et al. 2017

NPG Asia Mater

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Near-infrared (NIR)-induced chemothermal doxorubicin (DOX) release for anticancer activity was demonstrated using DOX-incorporated fully lateral nanodimensional graphene oxide (nGO) flakes layered with chitosan-polyethylene glycol (PEG) conjugate (nGO@DOX-cPEG) from a single-pass gas-phase self-assembly. Unlike most previously reported graphene oxide-based drug carriers, the proposed processing method introduced a fully nanoscale (both in lateral dimension and thickness) configuration without multistep wet physicochemical processes that enhance the drug-loading capacity and NIR-induced heat generation resulting from the increased surface area. The accumulation of nGO@DOX-cPEG flakes in prostate cancer cells enhanced apoptotic phenomena via the combined effects of DOX release and heat generation upon NIR irradiation. The combined anticancer effects were verified through in vivo assessment with better safety profiles than free DOX. The proposed strategy warrants continuous assembly of multimodal nanocarriers for the efficient treatment of prostate cancers and may be a promising candidate for advanced drug delivery systems.

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The chemotherapeutic potential of doxorubicin-loaded PEG-b-PLGA nanopolymersomes in mouse breast cancer model

Cited by 82 publications

References 50 publications

Next Generation Multiresponsive Nanocarriers for Targeted Drug Delivery to Cancer Cells

Next Generation Multiresponsive Nanocarriers for Targeted Drug Delivery to Cancer Cells

Enhanced plant growth promoting role of mPEG‐PLGA‐based nanoparticles as an activator protein PeaT1 carrier in wheat (Triticum aestivum L.)

Easy on-demand self-assembly of lateral nanodimensional hybrid graphene oxide flakes for near-infrared-induced chemothermal therapy

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