The China Alzheimer Report 2022

Ren, Rong; Qi, Jinlei; Lin, Shaohui; Liu, Xinya; Yin, Peng; Wang, Zhihui; Tang, Ran; Wang, Jintao; Huang, Qiang; Li, Jianping; Xie, Xinyi; Hu, Yongbo; Cui, Shishuang; Yi, Zhu; Yu, Xiaopeng; Wang, Pengfei; Zhu, Yikang; Wang, Yiran; Huang, Ya-Lin; Hu, Yisong; Wang, Ying; Li, Chunbo; Zhou, Maigeng; Wang, Gang

doi:10.1136/gpsych-2022-100751

Cited by 150 publications

(127 citation statements)

References 64 publications

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“…AD and relevant dementias are challenging conditions that seriously affect patients and their families ( Ren et al, 2022 ). Furthermore, there are currently no good methods or drugs to help patients with AD to recover or gain an improved quality of life, and the exact mechanism of AD remains elusive.…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis and identification of hub genes as novel biomarkers for Alzheimer’s disease

Zhao

Zhang²,

Wu³

et al. 2022

Front. Aging Neurosci.

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Alzheimer’s disease (AD) is an intractable and progressive neurodegenerative disorder that can lead to severe cognitive decline, impaired speech, short-term memory loss, and finally an inability to function in daily life. For patients, their families, and even all of society, AD can impart great emotional pressure and economic costs. Therefore, this study aimed to investigate potential diagnostic biomarkers of AD. Using the Gene Expression Omnibus (GEO) database, the expression profiles of genes were extracted from the GSE5281, GSE28146, and GSE48350 microarray datasets. Then, immune-related genes were identified by the intersections of differentially expressed genes (DEGs). Functional enrichment analyses, including Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, Disease Ontology (DO), and Gene Set Enrichment Analysis (GSEA), were performed. Subsequently, random forest models and least absolute shrinkage and selection operator regression were used to further screen hub genes, which were then validated using receiver operating characteristic (ROC) curve analysis. Finally, 153 total immune-related DEGs were identified in relation to AD. DO analysis of these immune-related DEGs showed that they were enriched in “lung disease,” “reproductive system disease,” and “atherosclerosis.” Single GSEA of hub genes showed that they were particularly enriched in “oxidative phosphorylation.” ROC analysis of AGAP3 yielded an area under the ROC curve of 0.878 for GSE5281, 0.727 for GSE28146, and 0.635 for GSE48350. Moreover, immune infiltration analysis demonstrated that AGAP3 was related to follicular helper T cells, naïve CD4 T cells, naïve B cells, memory B cells, macrophages M0, macrophages M1, macrophages M2, resting natural killer (NK) cells, activated NK cells, monocytes, neutrophils, eosinophils, and activated mast cells. These results indicate that identifying immune-related DEGs might enhance the current understanding of the development and prognosis of AD. Furthermore, AGAP3 not only plays a vital role in AD progression and diagnosis but could also serve as a valuable target for further research on AD.

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Section: Discussionmentioning

confidence: 99%

Integrated analysis and identification of hub genes as novel biomarkers for Alzheimer’s disease

Zhao

Zhang²,

Wu³

et al. 2022

Front. Aging Neurosci.

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“…The risk of cognitive decline and impairment among older adults is rapidly rising, and have become a major public health challenge globally ( Ren et al, 2022 ). According to the World Health Organization [WHO] (2020) , about 55 million older adults worldwide are living with dementia, among them 15 million reside in China ( Jia et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Quantifying the parallel mediation influence of body mass index and depression on physical activity and cognitive function among 3,611 Chinese older adults

Liu

Qiang

Dang

et al. 2022

Front. Aging Neurosci.

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BackgroundEngagement in physically active lifestyles brings multidimensional health benefits including better cognitive function. While prior studies examined the link between physical activity and cognitive function, a remaining unanswered question is what modifiable factors channel such effects.ObjectiveThis study investigates the extent to which subject’s body mass index (BMI) and depression mediate the link between physical activity and cognitive function among older adults in China.MethodsThis study builds a parallel structural equation model utilizing the 2013–2018 China Health and Retirement Longitudinal Study (CHARLS) dataset. We screened a total of 14,724 subjects, among which 3,611 subjects met the inclusion criteria. Physical activity, depression, and cognitive function are measured using the International Physical Activity Questionnaire (IPAQ), Center for Epidemiological Research Depression Scale (CES-D), and Mini-Mental State Examination (MMSE) instruments.ResultsParallel mediation analyses indicate that depression significantly mediates the link between physical activity and cognitive function (std. β = 0.023, p-value = 0.010), while no significant mediation was observed via BMI (std. β = 0.005, p-value = 0.155). Findings also show that physical activity is positively associated with cognitive function (std. β = 0.104, p-value = 0.004), whereas physical activity is inversely associated with BMI (std. β = –0.072, p-value = 0.045). Both BMI (std. β = –0.071, p-value = 0.042) and depression (std. β = –0.199, p-value = 0.001) are negatively associated with cognitive function.ConclusionThis study quantifies the positive association between physical activity and cognitive function in older Chinese adults, and uncovers a significant mediation channel occurring through depression. From a clinical perspective, physical behavioral modifications can lead to linked improvements in both mental and cognitive wellbeing for older adults.

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“…In the United States, an estimated 6.2 million people over 65 years old are living with AD, which makes AD presently the 6th leading cause of death [ 4 ]. There are approximately 10 million AD patients in China, and AD is the fifth leading cause of death among urban and rural residents [ 5 , 6 ]. Age-related cognitive decline, with the features of long disease duration, slow progress, and complex etiology, remains incurable, and there are even a few drugs that can prevent or delay its progress.…”

Section: Introductionmentioning

confidence: 99%

GDF11 Regulates PC12 Neural Stem Cells via ALK5-Dependent PI3K-Akt Signaling Pathway

Wang

Jiang

Liu

et al. 2022

IJMS

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Growth differentiation factor 11 (GDF11), belonging to the transforming factor-β superfamily, regulates anterior-posterior patterning and inhibits neurogenesis during embryonic development. However, recent studies recognized GDF11 as a rejuvenating (or anti-ageing) factor to reverse age-related cardiac hypertrophy, repair injured skeletal muscle, promote cognitive function, etc. The effects of GDF11 are contradictory and the mechanism of action is still not well clarified. The objective of the present study was to investigate effects of GDF11 on PC12 neural stem cells in vitro and to reveal the underlying mechanism. We systematically assessed the effects of GDF11 on the life activities of PC12 cells. GDF11 significantly suppressed cell proliferation and migration, promoted differentiation and apoptosis, and arrested cell cycle at G2/M phase. Both TMT-based proteomic analysis and phospho-antibody microarray revealed PI3K-Akt pathway was enriched when treated with GDF11. Inhibition of ALK5 or PI3K obviously attenuated the effects of GDF11 on PC12 neural stem cells, which exerted that GDF11 regulated neural stem cells through ALK5-dependent PI3K-Akt signaling pathway. In summary, these results demonstrated GDF11 could be a negative regulator for neurogenesis via ALK5 activating PI3K-Akt pathway when it directly acted on neural stem cells.

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The China Alzheimer Report 2022

Cited by 150 publications

References 64 publications

Integrated analysis and identification of hub genes as novel biomarkers for Alzheimer’s disease

Integrated analysis and identification of hub genes as novel biomarkers for Alzheimer’s disease

Quantifying the parallel mediation influence of body mass index and depression on physical activity and cognitive function among 3,611 Chinese older adults

GDF11 Regulates PC12 Neural Stem Cells via ALK5-Dependent PI3K-Akt Signaling Pathway

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