The Choice of Anesthetic Maintenance Technique Influences the Antiinflammatory Cytokine Response to Abdominal Surgery

Abstract

This study demonstrates that in addition to the widely reported proinflammatory cytokine response, elective abdominal surgery provokes an antiinflammatory response, which may be enhanced by total intravenous anesthesia. The ability of anesthetics to modify the cytokine response to surgery may have therapeutic potential.

Effect of spinal and general anesthesia on serum concentration of pro-inflammatory and anti-inflammatory cytokines

“…The enhanced release of IL-10 after surgery in patients receiving general anesthesia possibly reflects the reaction to limit a proinflammatory response or may be a result of direct effects of propofol and fentamyl on IL-10 producing cells. Gilliland et al (1997) also found increased levels of IL-10 and IL-1Ra postoperatively in patients receiving intravenous anesthesia with propofol and alfetanil and concluded about an enhanced anti-inflammatory response by i.v. anesthesia.…”

Prospective Evaluation of Post-implantation Inflammatory Response After EVAR for AAA: Influence on Patients' 30 Day Outcome

“…8,9,20,21 The type of anesthesia may also have a role by influencing the inflammatory cytokine response. 22 As most of the patients worldwide are operated on under general anesthesia, to avoid any possible bias all patients in this study were operated on under general anesthesia. In the present study the contrast media used as well as the aneurysm's thrombus load were not correlated with PIS.…”

Neuroendocrine stress response in gynecological laparoscopy: TIVA with propofol versus sevoflurane anesthesia

“…An important goal of current anesthetic research is to find the "stress-free anesthetic method" that can limit activation of the neuroendocrine, inflammatory, and immune responses [12,13]. Many studies suggest that the choice of anesthetic technique can influence the stress response by stimulating, inhibiting, or modulating the pathophysiologic pathways that cause neurohumoral and immunologic changes [11,[13][14][15].…”

“…Many studies suggest that the choice of anesthetic technique can influence the stress response by stimulating, inhibiting, or modulating the pathophysiologic pathways that cause neurohumoral and immunologic changes [11,[13][14][15].…”