The choice of antimicrobial therapy for infective endocarditis in the conditions of gram-positive microorganism dominance in the etiological structure in the russian federation

Abstract

The problem of infectious endocarditis currently deserves special attention. According to the data, intrahospital mortality caused by this pathology reaches 20%, which is largely due to the development of potential complications, the most common among which are the development and progression of heart failure, as well as thromboembolic manifestations with the damage to target organs of various localization. The article presents the results of a multicenter study establishing the features of antimicrobial therapy in patients with infectious endocarditis under the conditions of the dominance of gram-positive microorganisms in the etiological structure in the Russian Federation. 440 cases of definite and probable infectious endocarditis in the period from September 2006 to December 2020 were analyzed.

Review of international and European registers on infective endocarditis

“…В Российской Федерации выполнено несколько наблюдательных исследований, посвященных клиническим особенностям, практике диагностики и лечения ИЭ у взрослых [5,10]. Однако на сегодняшний день не существует единого национального регистра пациентов с данным заболеванием.…”

Antibacterial Therapy for Infectious Heart Diseases

“…К редким возбудителям ИЭ относят Coxiella burnetii, Bartonella spp., Chlamydia spp., Legionella spp. [3]. Отмечается тенденция к увеличению роли S. aureus, CoNS, Гр-и анаэробных бактерий, грибов и уменьшению роли стрептококков зеленящей группы [4].…”