The Cholesterol and Ascorbic Acid Content of the Adrenal, Liver, Brain, and Plasma Following Hemorrhage

Effect of α1- and α2-Adrenoceptor Agorists and Antagonists on ACTH Secretion in Intact and in Hypothalamic Deafferentated Rats

“…ACTH concentration in the serum was also increased after histamine injection and this increase was inhibited by antihistaminic drugs. It is generally known that hypotension which arises from hemor rhage causes activation of the pituitary adrenal system in animals (34)(35)(36)(37). Further more Gann et al (38,39) and Wood et al (40,41) have reported that adrenal cortical response to hypotension may be mediated in part by vagal pathways and by carotid baroreceptors.…”

THE ASSAY OF ADRENOCORTICOTROPHIC HORMONE BY THE ADRENAL ASCORBIC ACID-DEPLETION METHOD1

“…Employing difference in concentration of ascorbic acid in the two adrenals as the response Feb., 1946Apr., 1946May, 1946Nov., 1946Dec, 1946Aug., 1947Aug., 1947Aug., 1947Aug., 1947Oct., 1947 Oct Sealey and Sondern (1940).» the ascorbic acid content of adrenals of intact rats, such as bleeding (Sayers, Sayers, Liang and Long, 1945), and administration of epinephrine (Long and Fry, 1945), have no effect on the concentration of the vitamin in the adrenals of hypophysectomized rats. The following substances also gave no response in hypophysectomized rats, when administered in quantities equal to 0.5 ml.…”

Metabolic Functions of the Endocrine Glands

“…The improvement of tolerance to anoxia by glucose administration and experiments on adrenalectomy, adrenal hyper trophy, and cortical extracts offered more evidence concerning the adrenal function in anoxia. In the case of nonfatal hemorrhage, Sayers et al (203) observed that the fall in adrenal cholesterol and ascorbic acid resembled the changes occurring after the injection of adrenotropic hormone. The changes were prevented by hypophy sectomy.…”