The Cholesterol Lowering Effects of Eurycoma longifolia Jack (Tongkat Ali) Root Extract in Male Rats

Faisal, Ghasak Ghazi; Najmuldeen, Ghazi Faisal; Abllah, Zurainie; Radeef, Ali Sabri

doi:10.7454/msk.v21i1.6618

Cited by 8 publications

(14 citation statements)

References 16 publications

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“…Plant extracts with a high AI value indicates that the extracts have good antimicrobial activity against the selected pathogens 6 . The inhibitory activity of E. longifolia root extracts was in agreement with previous literature, it could inhibit S. aureus [8][9][10] and C. albicans 11 . R. elliptica was found to be able to inhibit the growth of C. albicans and S. aureus, which is contrary to a previous study where it was found to be inactive 12 ; however, there was no information about the extraction method for R. elliptica and the concentration used on that study.…”

Section: Discussionsupporting

confidence: 90%

Comparative antimicrobial studies on plant species known as ’Pasak Bumi': Eurycoma longifolia Jack., Rennelia elliptica Korth. and Trivalvaria macrophylla miq.

Kuspradini

Silau

Supartini³

et al. 2019

F1000Res

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Pasak Bumi is a local name for a medicinal plant in Kalimantan, Indonesia. It is a famous medicinal plant and commonly used in traditional medicine as an aphrodisiac, as well as in the treatment of malaria. Pasak Bumi is a commercial name for Eurycoma longifolia (Simaroubaceae) plant species. Besides Eurycoma longifolia there are two other plant species also known locally as Pasak Bumi, Rennelia elliptica (Rubiaceae) and Trivalvaria macrophylla (Annonaceae). This study was performed to investigate the antimicrobial activities of the different species of Pasak Bumi and its total phenol contents. The antimicrobial activity of the ethanol extract was determined using the Agar Well Diffusion method at various concentrations while the phenol content was determined by the Folin - Ciocalteu method. The results of the ethanol extract from the different root showed that the T. macrophylla had the highest phenol content, and the highest activity index (AI) was found in the E. longifolia (0.96 at 1000 µg concentration). The results of this study show that the three different Pasak Bumi have potential as antimicrobials against oral pathogen; 1 yeast: Candida albicans, and 3 bacterias: Staphylococcus aureus, Streptococcus mutans, and Streptococcus sobrinus.

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Section: Discussionsupporting

confidence: 90%

Comparative antimicrobial studies on plant species known as ’Pasak Bumi': Eurycoma longifolia Jack., Rennelia elliptica Korth. and Trivalvaria macrophylla miq.

Kuspradini

Silau

Supartini³

et al. 2019

F1000Res

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“…The results showed that the minimum inhibitory concentration of the extracts towards C.albicans and S.mutans were at the same concentration (25 mg/ml). The result is supported by the study done by previous researchers (Faisal GG et al, 2016) where the MIC obtained against C. Albicans was also at 25 mg/ml.…”

Section: Discussionsupporting

confidence: 82%

“…Currently researchers are exploring the medicinal benefits of herbal plants because they contain high amounts of biologically active compounds and produce less side effects and also to overcome the emergence of multi drug bacterial resistance. 1 Eurycoma longifolia jack is an herbal medicinal plant of South-East Asian origin, popularly recognized as 'Tongkat Ali. ' The plant parts have been traditionally used for its antimalarial, aphrodisiac, anti-diabetic, antimicrobial and antipyretic activities, which have also been proved scientifically.…”

Section: Introductionmentioning

confidence: 99%

Effects of Eurycoma Longifolia Jack (Tongkat Ali) Alcoholic Root Extract Against Oral Pathogens

Alloha¹,

Aziz²,

Faisal³

et al. 2019

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Introduction: Eurycoma longifolia jack (E.L) is a herbal medicinal plant of SouthEast Asian origin, popularly recognized as 'Tongkat Ali.' The plant roots have been scientifically proven to have many biological effects including antibacterial activity however, no previous research to date has studied the effect on oral pathogens including cariogenic bacteria. This study was done to determine the antibacterial and antifungal activities of E.L. root extract against three common oral pathogens. Material and Methods: The microorganisms used were Candida albicans, Streptococcus mutans and Lactobacillus casei. E.L root was extracted using soxhlet method. Disc diffusion assay was conducted using extract concentration of 200 mg/ml. Nystatin and Ampicillin were used as positive control for fungal and bacterial tests respectively. Minimum Inhibitory Concentration (MIC) was done to determine the lowest inhibitory concentration of the extract on the microorganisms. Results: E.L extract inhibited the growth of Candida albicans and Streptococcus mutans at a concentration of 200 mg/ ml with a zone of inhibition of 16.0 ± 3.0 mm and 7.0 ± 1.0 mm respectively. There was no antimicrobial effect of the extract on Lactobacillus casei. The MIC of E.L extract against both Candida albicans and Streptococcus mutans was 25 mg/ml. Conclusions: The results from this study revealed the potential use of Eurycoma longifolia jack as an antimicrobial agent which can be used to produce new oral care products.

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“…EL has potent antibacterial, antimalarial, antipyretic, antifungal, and antioxidant properties. 11,12 The roots of the EL contain numerous phytochemical bioactive compounds including quassinoids and squalene derivatives and eurycolactones A-C. 13…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Eurycoma longifolia Jack Root Extract Against High-Fat Diet Induced Testicular Damage in Sprague-Dawley Rats

Al-Ani¹,

Ku-Zaifah²,

Al-Joufi³

et al. 2019

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Objective: The aims of this study were to investigate the adverse effects of the high-fat-diet (HFD) on the testosterone level and testicular structure of male rats as well as to examine whether Eurycoma Longifolia (EL) is able to ameliorate these effects. Methods: Twenty-four male Sprague-Dawley (SD) rats were divided into four groups each containing 6 rats. Group ND was given only normal diet, group NDEL was given normal diet and EL extracts (15 mg/ kg) dissolved in distilled water, group HFD was given only high-fat-diet and group HFDEL was given high-fat-diet and EL extracts (15 mg/kg). EL was administered orally for 12 weeks. The animal's testosterone level was measured at week 0, 6 and 12. The rats were sacrificed at the end of 12 th weeks and the testes samples were processed for histological examination Results: The testosterone level was significantly increased (p < 0.05) in the in the treated rats with EL (NDEL and HFDEL) compared with ND and HFD groups. Treatment with HFD revealed a marked degeneration of the seminiferous tubule epithelium and disruption of interstitial cells of the testis thereby interfering with spermatogenesis. Treatment of HFD rats with El reduced the adverse effects of HFD and improved the morphological structure of the seminiferous tubules. Conclusion: These findings revealed that EL has ameliorative effects against the testicular damage caused by high-fat-diet.

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The Cholesterol Lowering Effects of Eurycoma longifolia Jack (Tongkat Ali) Root Extract in Male Rats

Cited by 8 publications

References 16 publications

Comparative antimicrobial studies on plant species known as ’Pasak Bumi': Eurycoma longifolia Jack., Rennelia elliptica Korth. and Trivalvaria macrophylla miq.

Comparative antimicrobial studies on plant species known as ’Pasak Bumi': Eurycoma longifolia Jack., Rennelia elliptica Korth. and Trivalvaria macrophylla miq.

Effects of Eurycoma Longifolia Jack (Tongkat Ali) Alcoholic Root Extract Against Oral Pathogens

Protective Role of Eurycoma longifolia Jack Root Extract Against High-Fat Diet Induced Testicular Damage in Sprague-Dawley Rats

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