The Cholesterol/Saturated-Fat Index: An Indication of the Hypercholesterolaemic and Atherogenic Potential of Food

Connor, Sonjal .; Artaud-Wild, S M; Classick-Kohn, CarolynJ.; Gustafson, J R; Flavell, DonnaP.; Hatcher, Lauren; Connor, W E

doi:10.1016/s0140-6736(86)91384-x

Cited by 117 publications

(61 citation statements)

References 16 publications

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“…Excessive intake of Western diets is well known to increase the risk for CHD through induction of obesity and hyperlipidemia (Connor et al, 1986;Kratz, 2005). MTP inhibitors are one of the potential candidates for lipid-lowering agents by inhibiting dietary lipid absorption from the intestine.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Characterization of Diethyl-2-({3-dimethylcarbamoyl-4-[(4′-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}acetyloxymethyl)-2-phenylmalonate (JTT-130), an Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein

Mera¹,

Odani²,

Kawai³

et al. 2010

J Pharmacol Exp Ther

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Inhibitors of microsomal triglyceride transfer protein (MTP) expressed in the liver and small intestine are potential candidates for lipid-lowering agents. However, inhibition of hepatic MTP could lead to significant safety issues such as fatty liver disease. To develop a specific inhibitor of intestinal MTP, JTT-130, was designed to be rapidly hydrolyzed in the absorption process. Here, we describe JTT-130, an intestine-specific MTP inhibitor, and evaluate its pharmacological properties. In in vitro metabolic stability tests, JTT-130 was readily hydrolyzed during incubation with liver S9 from humans, hamsters, and rats. In an in vitro triglyceride (TG) transfer assay with human intestinal MTP, JTT-130 potently inhibited TG transfer activity with an IC 50 value of 0.83 nM. When orally administered to hamsters, JTT-130 significantly suppressed an increase in chylomicron-TG after olive oil loading at 0.3 mg/kg and above but did not inhibit TG secretion from the liver at doses of up to 1000 mg/kg, indicating an inhibitory action highly specific for the small intestine. In rats orally administered [14 C]triolein, JTT-130 potently suppressed an increase in blood 14 C radioactivity and increased 14 C radioactivity in the upper small intestine and the intestinal lumen. In hyperlipidemic hamsters fed a high-fat and high-cholesterol diet, repeated dosing with JTT-130 for 2 weeks reduced TG and cholesterol levels in the plasma and TG content in the liver. These results indicated that JTT-130 is a potent inhibitor specific to intestinal MTP and suggested that JTT-130 would be a useful compound for the treatment of dyslipidemia without inducing hepatotoxicity.

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Section: Discussionmentioning

confidence: 99%

Pharmacological Characterization of Diethyl-2-({3-dimethylcarbamoyl-4-[(4′-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}acetyloxymethyl)-2-phenylmalonate (JTT-130), an Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein

Mera¹,

Odani²,

Kawai³

et al. 2010

J Pharmacol Exp Ther

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“…In addition, the hyperlipidemic and atherogenic potential of mussel lipids, related to cholesterol, SFA, and unsaturated FA content, were determined. To assess the dietary effect of the mussel lipid consumption on serum cholesterol levels, two indices were calculated: cholesterol/SFA index (CSI) and cholesterol index (CI) [15,16].…”

Section: Nutritional Quality Indicesmentioning

confidence: 99%

Assessment of Proximate and Bioactive Lipid Composition of Black Sea Mussels (M. galloprovincialis) from Bulgaria

Merdzhanova¹,

Dobreva²,

Panayotova³

2018

Biological Resources of Water

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Farmed marine mussels from genera Mytilus are important for the human diet by providing high levels of proteins, omega-3 polyunsaturated fatty acids (PUFAs), fat soluble vitamins and carbohydrates. Recently, black mussels are commercially important species from the Bulgarian Black Sea. The aim of this study was to assess the seasonal changes in proximate composition and to focus on the lipid bioactive components such as fatty acids, cholesterol, fat-soluble vitamins (A, E and D 3 ), and carotenoids (astaxanthin, beta-carotene) in farmed mussels (M. galloprovincialis) from the northern part of the Bulgarian Black Sea coast. All analyzed samples presented high protein and low lipid content. The fatty acids (FA) profile was characterized by the highest amount of PUFA, as 22:6 omega-3 (n-3) dominated, regardless of the seasons. In all seasons, the content of n-3 was significantly higher than the omega-6 PUFA. The amounts of cholesterol were in the range 62.3 (summer) to 78 (autumn) mg 100 g ww) were found in the summer season. The studied mussel aquaculture from Bulgaria presented a high beneficial potential in all seasons in terms of human health protection.

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“…PUFA/SFA and n-6 PUFA/n-3 PUFA ratios, a modification of the cholesterol-saturated fatty acid index (CSI) of Connor et al (1986), the atherogenic index (AI) and the thrombogenic index (TI) (Di Lorenzo et al, 2001) were used for assessing egg lipid quality.…”

Section: Fat Lipogenesis and Quality Indexesmentioning

confidence: 99%

The effect of dietary fat on the fatty acid composition and cholesterol content of Hy-line and Warren hen eggs

et al. 2009

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350 throughout the study. The cholesterol egg content was higher at the animal fat plus soybean oil than at the animal fat or the olein plus soybean oil blend. Overall, results showed that changes in dietary lipids influenced fatty acid composition and hence atherogenic and thrombogenic indexes much more than the strain. KEY-WORDS: Atherogenic index -Cholesterol -Egg composition -Fatty acids -Hen-strain -Thrombogenic index.

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The Cholesterol/Saturated-Fat Index: An Indication of the Hypercholesterolaemic and Atherogenic Potential of Food

Cited by 117 publications

References 16 publications

Pharmacological Characterization of Diethyl-2-({3-dimethylcarbamoyl-4-[(4′-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}acetyloxymethyl)-2-phenylmalonate (JTT-130), an Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein

Pharmacological Characterization of Diethyl-2-({3-dimethylcarbamoyl-4-[(4′-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}acetyloxymethyl)-2-phenylmalonate (JTT-130), an Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein

Assessment of Proximate and Bioactive Lipid Composition of Black Sea Mussels (M. galloprovincialis) from Bulgaria

The effect of dietary fat on the fatty acid composition and cholesterol content of Hy-line and Warren hen eggs

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