2013
DOI: 10.1016/j.etap.2012.12.001
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The chronic effects of low lead level on the expressions of Nrf2 and Mrp1 of the testes in the rats

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Cited by 22 publications
(11 citation statements)
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“…Previous studies have suggested that a variety of cytokines and antioxidants could counteract the action of such chemicals causing up-regulation of HO-1 and γ-GCS expression [53,54,55,56,57]. γ-GCS regulated by the Nrf2/ARE signaling pathway is the rate-limiting enzyme for synthesis of GSH [54].…”
Section: Discussionmentioning
confidence: 99%
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“…Previous studies have suggested that a variety of cytokines and antioxidants could counteract the action of such chemicals causing up-regulation of HO-1 and γ-GCS expression [53,54,55,56,57]. γ-GCS regulated by the Nrf2/ARE signaling pathway is the rate-limiting enzyme for synthesis of GSH [54].…”
Section: Discussionmentioning
confidence: 99%
“…γ-GCS regulated by the Nrf2/ARE signaling pathway is the rate-limiting enzyme for synthesis of GSH [54]. Heme oxygenase 1 (HO-1), a known target of Nrf2-regulated transcription and an antioxidative, cytoprotective protein in different types of cells, plays an important role in cytoprotection when oxidative stress and cellular injury occurs, and Nrf2 directly regulates its expression [55,56]. Our results showed that PCs could up-regulate the Nrf2 downstream gene HO-1 and γ-GCS expression.…”
Section: Discussionmentioning
confidence: 99%
“…Arsenic, Cd, Cr, Ni, and Pb were found to increase the urinary level of PAH metabolites (Wang et al 2015a). In another study, only Cd increased the oxidative stress of PAHs in Taiwanese traffic conductors, but no such interactions were found between nickel (Ni), As, Pb and PAHs (Huang et al 2013).…”
Section: Exposure To Pahs and Metal Mixturesmentioning
confidence: 99%
“…Lead causes reduction in hemoglobin synthesis, and neurological, neurobehavioral and developmental effects in children (ATSDR 2007b (ATSDR 2015). The mixed contamination of PAHs and metals is ubiquitous in the environment and has received significant attention due to their known adverse health effects to humans and other organisms (Huang et al 2013, Sun et al 2014, Wang et al 2015a. Soil is one of the major sinks for these mixed contaminants and their co-occurrence at various contaminated sites has been reported around the world (Shen et al 2005, Brown and Peake 2006, Song et al 2006, Thavamani et al 2011.…”
Section: Introductionmentioning
confidence: 99%
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