This paper explores how Muslim immigrants negotiate their family practices and religious identities in secular Guangzhou, a global city in south China, drawing on an in-depth qualitative analysis. It provides a lens for better understanding the interrelationship between family practices, transnational mobility, and religious values spatially in the Chinese context. The key arguments of this research suggest that transnational mobility plays important roles in making, remaking, and unmaking of connections between family and religion. Moreover, both family spaces and religious spaces are dynamic and on the move. As an empirical study on family and religion in the Chinese context, this research can not only be read as a contribution to family and religious geographies in an everyday setting, but also one of the first everyday geography studies of Islam and Muslims in globalised China.