The Ciji-Hua’ai-Baosheng II Formula Attenuates Chemotherapy-Induced Anorexia in Mice With H22 Hepatocellular Carcinoma

Xi, Shengyan; Zhai, Xiangyang; Wang, Yanan; Gong, Yuewen; Fu, Biqian; Gao, Cong-Zhang; Guo, Xiangfeng; Li, Yunhong; Wang, Zheng; Huang, Shuqiong; Lü, Dawei; Zhao, Yufang; Qian, Lei; Wang, Yanhui

doi:10.3389/fphar.2021.715824

Cited by 8 publications

(4 citation statements)

References 50 publications

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“…In clinical practice, side effects of 5-FU include anorexia due to nausea and vomiting (Shih et al 2007). Anticancer drugs are known to stimulate the secretion of 5-HT and substance P proteins in the gastrointestinal tract which bind to 5-HT3 and NK1 receptors to generate nerve impulses; these signals are transmitted to the vomiting centre to cause a vomiting reaction (Xi et al 2021). The weight loss of mice by 5-FU administration observed in this experiment was considered to be due to the decrease in food intake caused by anorexia.…”

Section: Discussionmentioning

confidence: 76%

Efficacy of ginsenoside treatment to alleviate anticancer-drug induced mucoenteritis in mice

Kato¹,

Jonan²,

Sugahara³

et al. 2022

IPh

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, which is widely used as an anticancer drug, causes enteritis due to disruption of mucosal tissue, resulting in diarrhoea and body weight loss. Ginsenoside Rd (GRd) and ginsenoside Re (GRe) are two of the saponins contained in carrots. Their anti-inflammatory effects on the digestive system have been reported, but their effects on small intestinal mucositis have not been studied much. This study investigated the effect of GRd and GRe on 5-FU-induced mucoenteritis. GRd and GRe did not affect weight loss or exacerbation of diarrhoea due to 5-FU administration in mice. Histopathological observations showed that 5-FU reduced the shortening of intestinal villi and the number of crypts and cells compared to the vehicle group. However, co-administration of GRd and GRe, significantly suppressed the decrease in the number of small intestinal crypts and cells in the crypt by 5-FU treatment. It indicates that 5-FU-induced enteritis is attenuated by the co-administration of GRd and GRe. The expression of NF-κB was increased by 5-FU administration and this increase was clearly suppressed in the group that was co-administered GRd. Although the anti-inflammatory effects of GRd and GRe have been reported based on various mechanisms in many models, the mechanism of their enteritis-suppressing action in anticancer drug-induced enteritis has not been clarified. It was reported that the anti-inflammatory effect of GRd was due to the suppression of NF-κB expression; we concluded that NF-κB may be one of the molecules involved in the suppression of 5-FU-incuced enteritis.

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Section: Discussionmentioning

confidence: 76%

Efficacy of ginsenoside treatment to alleviate anticancer-drug induced mucoenteritis in mice

Kato¹,

Jonan²,

Sugahara³

et al. 2022

IPh

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“…Furadiene resisted angiogenesis and induced the production of reactive oxygen species (ROS) [ 83 , 84 ]. Ciji-Hua’ai-Baosheng II Formula could improve the anorexia and gastrointestinal injury caused by chemotherapy in tumor-bearing mice by affecting the appetite regulatory factors in the hypothalamic central nervous system and feeding area, and enhance the antitumor effect of 5-FU [ 85 ]. Curcumin is an anticancer component of turmeric.…”

Section: Methodsmentioning

confidence: 99%

Frontier progress of the combination of modern medicine and traditional Chinese medicine in the treatment of hepatocellular carcinoma

Wei

Wang

Jing³

et al. 2022

Chin Med

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Hepatocellular carcinoma (HCC, accounting for 90% of primary liver cancer) was the sixth most common cancer in the world and the third leading cause of cancer death in 2020. The number of new HCC patients in China accounted for nearly half of that in the world. HCC was of occult and complex onset, with poor prognosis. Clinically, at least 15% of patients with HCC had strong side effects of interventional therapy (IT) and have poor sensitivity to chemotherapy and targeted therapy. Traditional Chinese medicine (TCM), as a multi-target adjuvant therapy, had been shown to play an active anti-tumor role in many previous studies. This review systematically summarized the role of TCM combined with clinically commonly used drugs for the treatment of HCC (including mitomycin C, cyclophosphamide, doxorubicin, 5-fluorouracil, sorafenib, etc.) in the past basic research, and summarized the efficacy of TCM combined with surgery, IT and conventional therapy (CT) in clinical research. It was found that TCM, as an adjuvant treatment, played many roles in the treatment of HCC, including enhancing the tumor inhibition, reducing toxic and side effects, improving chemosensitivity and prolonging survival time of patients. This review summarized the advantages of integrated traditional Chinese and modern medicine in the treatment of HCC and provides a theoretical basis for clinical research.

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“…NPY decreased PD-1+ T cells and PD-1 expression/cell in T cells of both healthy individuals and patients with hepatocellular carcinoma; the peptide augmented T cell proliferation and the eradication of hepatocellular carcinoma cells [ 162 ]. In an experimental animal model of hepatocellular carcinoma, the Ciji-Hua’ai-Baosheng II formula (a traditional Chinese medicine strategy targeting the adverse effects mediated by chemotherapy in cancer patients) increased serum NPY level and NPY expression in the hypothalamus [ 163 ].…”

Section: Involvement Of Neuropeptide Y Peptide Yy and Pancreatic Poly...mentioning

confidence: 99%

Neuropeptide Y Peptide Family and Cancer: Antitumor Therapeutic Strategies

Sánchez

Rodríguez

Coveñas

2023

IJMS

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Currently available data on the involvement of neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP) and their receptors (YRs) in cancer are updated. The structure and dynamics of YRs and their intracellular signaling pathways are also studied. The roles played by these peptides in 22 different cancer types are reviewed (e.g., breast cancer, colorectal cancer, Ewing sarcoma, liver cancer, melanoma, neuroblastoma, pancreatic cancer, pheochromocytoma, and prostate cancer). YRs could be used as cancer diagnostic markers and therapeutic targets. A high Y1R expression has been correlated with lymph node metastasis, advanced stages, and perineural invasion; an increased Y5R expression with survival and tumor growth; and a high serum NPY level with relapse, metastasis, and poor survival. YRs mediate tumor cell proliferation, migration, invasion, metastasis, and angiogenesis; YR antagonists block the previous actions and promote the death of cancer cells. NPY favors tumor cell growth, migration, and metastasis and promotes angiogenesis in some tumors (e.g., breast cancer, colorectal cancer, neuroblastoma, pancreatic cancer), whereas in others it exerts an antitumor effect (e.g., cholangiocarcinoma, Ewing sarcoma, liver cancer). PYY or its fragments block tumor cell growth, migration, and invasion in breast, colorectal, esophageal, liver, pancreatic, and prostate cancer. Current data show the peptidergic system’s high potential for cancer diagnosis, treatment, and support using Y2R/Y5R antagonists and NPY or PYY agonists as promising antitumor therapeutic strategies. Some important research lines to be developed in the future will also be suggested.

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The Ciji-Hua’ai-Baosheng II Formula Attenuates Chemotherapy-Induced Anorexia in Mice With H22 Hepatocellular Carcinoma

Cited by 8 publications

References 50 publications

Efficacy of ginsenoside treatment to alleviate anticancer-drug induced mucoenteritis in mice

Efficacy of ginsenoside treatment to alleviate anticancer-drug induced mucoenteritis in mice

Frontier progress of the combination of modern medicine and traditional Chinese medicine in the treatment of hepatocellular carcinoma

Neuropeptide Y Peptide Family and Cancer: Antitumor Therapeutic Strategies

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