The Citrus Flavanone Naringenin Protects Myocardial Cells against Age‐Associated Damage

Pozzo, Eleonora Da; Costa, Barbara; Cavallini, Chiara; Testai, Lara; Martelli, Alma; Calderone, Vincenzo; Martini, Claudia

doi:10.1155/2017/9536148

Cited by 63 publications

(41 citation statements)

References 75 publications

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“…ROS, mitochondrial metabolic activity, mitochondrial calcium buffer capacity, and estrogenic signaling functions). Overall the authors suggest that naringenin has antiaging effects on myocardial cells [87].…”

Section: Flavanonesmentioning

confidence: 94%

Pure Polyphenols Applications for Cardiac Health and Disease

Santos

Gomes

Oudot

et al. 2018

CPD

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Polyphenols are natural compounds present in fruits and vegetables that can exert beneficial effects on human health and notably, on the cardiovascular system. Some of these compounds showed significant protective activities toward atherosclerosis, hypertension, myocardial infarction, anthracyclin-induced cardiomyopathy, angiogenesis as well as heart failure. Polyphenols can act through systemic effects as well as through modulation of signaling pathways such as redox signaling, inflammation, autophagy and cell death in the heart and vessels. These effects can be mediated by changes in expression level and by post-translational modifications of proteins (e.g. Stat1, CaMKII, Sirtuins, BCL-2 family members, PDEs, TRF2, eNOS and SOD). This non-comprehensive short review aims to summarize recent knowledge on the main pharmacological effects and mechanisms of cardioprotection of pure polyphenols, using different approaches such as cell culture, animal models and human studies.

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Section: Flavanonesmentioning

confidence: 94%

Pure Polyphenols Applications for Cardiac Health and Disease

Santos

Gomes

Oudot

et al. 2018

CPD

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“…Orange is a widely available and economically significant fruit containing a large number of polyphenolic secondary metabolites with potent antioxidant and antiproliferative activities [14]. Citrus flavanone naringenin was shown to prevent myocardial cells from senescence through the modulation of cell cycle regulators, ROS levels, and mitochondrial metabolic activities [15]. The juice of bergamot (Citrus bergamia Risso et Poiteau) counteracted the senescence processes in senescent H9c2 cells and old mice [16].…”

Section: Introductionmentioning

confidence: 99%

Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans

et al. 2020

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Orange, with various bioactive phytochemicals, exerts various beneficial health effects, including anti-cancer, antioxidant, and anti-inflammatory properties. However, its anti-aging effects remain unclear. In this study, the Caenorhabditis elegans (C. elegans) model was used to evaluate the effects of orange extracts on lifespan and stress resistance. The results indicated that orange extracts dose-dependently increased the mean lifespan of C. elegans by 10.5%, 18.0%, and 26.2% at the concentrations of 100, 200, and 400 mg/mL, respectively. Meanwhile, orange extracts promoted the healthspan by improving motility, and decreasing the accumulation of age pigment and intracellular reactive oxygen species (ROS) levels without damaging fertility. The survival rates of orange extract-fed worms were obviously higher than those of untreated worms against thermal and ultraviolet-B (UV-B) stress. Moreover, the activities of superoxide dismutase (SOD) and catalase (CAT) were significantly enhanced while malondialdehyde (MDA) contents were diminished. Further investigation revealed that worms supplemented with orange extracts resulted in upregulated levels of genes, including daf-16, sod-3, gst-4, sek-1, and skn-1, and the downregulation of age-1 expression. These findings revealed that orange extracts have potential anti-aging effects through extending the lifespan, enhancing stress resistance, and promoting the healthspan.

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“…It has been reported that NG has several binding sites. NG binding to oestrogen receptors was reported to induce bidirectional adjusting effects, and in another study, to inhibit cell proliferation . Immunosuppressive activity of NG was regulated by its direct interaction with the ligand‐binding site of aryl hydrocarbon receptor .…”

Section: Discussionmentioning

confidence: 94%

Inhibitory effect of naringenin via IL‐13 level regulation on thymic stromal lymphopoietin‐induced inflammatory reactions

Han

Moon

Ryu

et al. 2017

Clin Exp Pharma Physio

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Naringenin (NG) has various beneficial properties, such as anti-cancer and anti-inflammatory effects. Thymic stromal lymphopoietin (TSLP) induces mast cell proliferation and inflammatory reactions. The aim of this study was to investigate the regulatory effect of NG on TSLP-induced mast cell proliferation and inflammatory reactions using human mast cell line (HMC-1) cells. HMC-1 cells were pre-treated with NG and then treated with TSLP. HMC-1 cells proliferation was determined by quantifying bromodeoxyuridine incorporation. Levels of anti-apoptotic and pro-apoptotic factors were analyzed by western blot analysis. The productions and mRNA expressions of interleukin (IL)-13 and tumour necrosis factor-α (TNF-α) were analyzed by ELISA and quantitative real-time PCR. We found that NG significantly attenuated HMC-1 cells proliferation and Ki-67 mRNA expression promoted by TSLP. NG significantly suppressed mRNA expression of TSLP receptor and IL-7 receptor α in TSLP-treated HMC-1 cells. NG significantly down-regulated levels of phosphorylated-signal transducer and activation of transcription 6 and murine double-minute 2 in TSLP-treated HMC-1 cells, up-regulated levels of cleaved poly ADP-ribose polymerase and p53 in TSLP-treated HMC-1 cells. Furthermore, NG significantly decreased the productions and mRNA expressions of IL-13 and TNF-α in TSLP-treated HMC-1 cells. These results suggest NG has an inhibitory effect on mast cell-mediated allergic inflammatory reactions.

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The Citrus Flavanone Naringenin Protects Myocardial Cells against Age‐Associated Damage

Cited by 63 publications

References 75 publications

Pure Polyphenols Applications for Cardiac Health and Disease

Pure Polyphenols Applications for Cardiac Health and Disease

Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans

Inhibitory effect of naringenin via IL‐13 level regulation on thymic stromal lymphopoietin‐induced inflammatory reactions

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