The classification of neuropsychiatric disorders in epilepsy: A proposal by the ILAE Commission on Psychobiology of Epilepsy

Krishnamoorthy, Ennapadam S.; Trimble, Michael; Blumer, Dietrich

doi:10.1016/j.yebeh.2006.10.002

Cited by 163 publications

(128 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One limitation of our study was its inability to identify mood disorders not yet classified by DSM-IV 26 . Another limitation of our study is its cross-sectional design which did not allow us to identify psychiatric disorders temporally related to seizures (peri-ictal and interictal symptoms).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of psychiatric comorbidities in temporal lobe epilepsy in a Southern Brazilian population

Bragatti

Torres

Londero

et al. 2011

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

A great prevalence of psychiatric disorders in epilepsy is well demonstrated, although most studies have used unstructured psychiatric interviews for diagnosis. Here we present a study evaluating the prevalence of psychiatric comorbidities in a cohort of Southern Brazilian patients with temporal lobe epilepsy (TLE) using a structured clinical interview. We analyzed 166 patients with TLE regarding neuropsychiatric symptoms through the Structured Clinical Interview for DSM-IV. One hundred-six patients (63.9%) presented psychiatric comorbidities. Mood disorders were observed in 80 patients (48.2%), anxiety disorders in 51 patients (30.7%), psychotic disorders in 14 (8.4%), and substance abuse in 8 patients (4.8%) respectively. Our results agree with literature data where most authors detected mental disorders in 10 to 60% of epileptic patients. This wide variation is probably attributable to different patient groups investigated and to the great variety of diagnostic methods. Structured psychiatric interviews might contribute to a better evaluation of prevalence of psychiatric comorbidities in TLE. Key words: seizures, epidemiology, behavioral neurology, chronic psychiatric illness, neurology.Prevalência de comorbidades psiquiátricas na epilepsia do lobo temporal em uma população do sul do Brasil RESUMO Embora muitos estudos tenham demonstrado uma alta prevalência de transtornos psiquiátricos em pacientes com epilepsia, a maioria utilizou entrevistas psiquiátricas não-estruturadas para o diagnóstico. Este método pode levar a diferenças significativas nos resultados. Nós estudamos a prevalência de comorbidades psiquiátricas em pacientes com epilepsia do lobo temporal (ELT), utilizando uma entrevista clínica estruturada. Foram estudados 166 pacientes com ELT, aos quais foi aplicada a Entrevista Clínica Estruturada para o DSM-IV (SCID). Cento e seis pacientes (63,9%) apresentaram comorbidades psiquiátricas. Transtornos de humor, observados em 80 pacientes (48,2%), foram o transtorno neuropsiquiátrico mais comum. Transtornos de ansiedade, observados em 51 pacientes (30,7%), foram a segunda comorbidade psiquiátrica mais frequente. Transtornos psicóticos foram encontrados em 14 (8,4%), e abuso de substâncias foram observados em 8 pacientes (4,8%), respectivamente. Nossos resultados estão de acordo com os dados da literatura, que demonstra problemas psiquiátricos em 10-60% dos pacientes com epilepsia. A grande variação dos resultados pode ser atribuída aos diferentes grupos de pacientes estudados e à variabilidade de métodos diagnósticos empregados. Entrevistas psiquiátricas estruturadas podem contribuir para uma avaliação mais adequada da real prevalência de comorbidades psiquiátricas na ELT.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of psychiatric comorbidities in temporal lobe epilepsy in a Southern Brazilian population

Bragatti

Torres

Londero

et al. 2011

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…Efforts are being made to reverse this situation 5 . The International League Against Epilepsy (ILAE) commission on the psychobiology of epilepsy has evolved through this process and developed an expert consensus that was directed to provide a more comprehensive and acceptable system of classification for PD in epilepsy 6 . Interictal dysphoric disorder (IDD) was first described by Kraepelin 7 in 1923.…”

Section: Introductionmentioning

confidence: 99%

Interictal dysphoric disorder: a frequent psychiatric comorbidity among patients with epilepsy who were followed in two tertiary centers

Nascimento

Oliva

Franco

et al. 2013

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

ARTICLEInterictal dysphoric disorder: a frequent psychiatric comorbidity among patients with epilepsy who were followed in two tertiary centers ABSTRACTPsychiatric disorders are frequent among patients with epilepsy. Data in the literature have shown a heterogeneous clinical presentation of psychiatric disorders in patients with epilepsy. Interictal dysphoric disorder could be a specific psychiatric comorbidity associated with epilepsy, primarily in patients treated in tertiary centers. Objective: The present study aimed to determine the prevalence of interictal dysphoric disorder among patients with epilepsy who were followed in two tertiary epilepsy services in Brazil. Method: Sixty-five patients with epilepsy completed the Portuguese version of the Interictal Dysphoric Disorder Inventory. Results: Thirty-three (50.7%) patients fulfilled the diagnostic criteria for interictal dysphoric disorder, although all participants answered positively to having at least one key symptom. Conclusion: The high rate of patients with epilepsy who fulfilled the diagnosis of interictal dysphoric disorder confirms an association between epilepsy and psychiatric disorders. However, there is clearly a need to improve diagnostic tools to allow better differentiation between interictal dysphoric disorder and other psychiatric disorders.Keywords: epilepsy, interictal dysphoric disorder, psychiatric disorders. RESUMOTranstornos psiquiátricos são frequentes entre pacientes com epilepsia. Estudos evidenciam apresentações clínicas heterogêneas neste grupo. O transtorno disfórico interictal pode um transtorno específico destes pacientes, particularmente naqueles acompanhados em centros terciários. Objetivo: Determinar a prevalência de transtorno disfórico interictal entre pacientes com epilepsia atendidos em dois serviços terciários de epilepsia do Brasil. Método: Sessenta e cinco pacientes foram convidados a responder a versão brasileira do Interictal Dysphoric Disorder Inventory adaptado e validado para o Português. Resultados: Trinta e três pacientes (50,7%) preencheram critérios para transtorno disfórico interictal, embora todos os entrevistados tenham afirmado que são acometidos por ao menos um dos sintomas-chave. Conclusão: A alta prevalência de transtorno disfórico interictal em pacientes com epilepsia pode ser um indício da associação entre epilepsia e transtornos psiquiátricos. No entanto, é necessário melhorar a acurácia dos instrumentos de diagnóstico para poder diferenciar casos de transtorno disfórico interictal de outros transtornos psiquiátricos.Palavras-chave: epilepsia, transtorno disfórico interictal, transtornos psiquiátricos.

show abstract

“…A number of authors agree that up to 50% of patients with epilepsy and depression present psychiatric symptoms that are not captured by standardized classificatory systems such as DSM or ICD [16][17][18][19][20]. This observation might explain the high variability in epidemiological data on mood disorders in epilepsy.…”

Section: The Non-conforming Features Of Mood Disorders In Epilepsy Anmentioning

confidence: 99%

The interictal dysphoric disorder of epilepsy: Legend or reality?

Mula

2016

Epilepsy & Behavior

View full text Add to dashboard Cite

For a long time, the relationships between epilepsy and mood disorders captured the attention of clinicians and neuroscientists. The existence of a peculiar clinical presentation for mood disorders in epilepsy has been matter of debate since the early reports of Kraepelin and Bleuler. The interictal dysphoric disorder (IDD) represents the modern reinterpretation of such early observations. This paper reviews current research on this topic discussing clinical implications, phenomenological observations and directions for future research.

show abstract

The classification of neuropsychiatric disorders in epilepsy: A proposal by the ILAE Commission on Psychobiology of Epilepsy

Cited by 163 publications

References 15 publications

Prevalence of psychiatric comorbidities in temporal lobe epilepsy in a Southern Brazilian population

Prevalence of psychiatric comorbidities in temporal lobe epilepsy in a Southern Brazilian population

Interictal dysphoric disorder: a frequent psychiatric comorbidity among patients with epilepsy who were followed in two tertiary centers

The interictal dysphoric disorder of epilepsy: Legend or reality?

Contact Info

Product

Resources

About