The Clinical and Histopathological Significance of Performing Surgical Cavity Random Biopsy in Breast Conserving Surgery on Disease Course and LocalRecurrence

Rahmani, Samir; Brown, Joshua; Gendy, R.

doi:10.4172/2572-4118.1000104

Cited by 2 publications

(1 citation statement)

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“…Morphologically, chronic infammation is the presence of lymphocytes, plasma cells, and macrophages in the tissues [51]. During chronic infammation, there is the release of certain mediators such as proinfammatory cytokines (IL and TNF-alpha), colony stimulating factors (CSF), interferons and platelet derived growth factors (PDGFs) [52][53][54], and free radicals such as NO [55]. Te results also show that the hydroethanolic extract of the roots of V. guineensis signifcantly and in a dose-dependent manner inhibited the chronic infammation induced by formalin.…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Vivo Anti-Inflammatory Properties of the Hydroethanolic Extract of the Roots of Vernonia guineensis (Asteraceae)

Nana

Mimb

Atsamo

et al. 2023

International Journal of Inflammation

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In traditional Cameroonian medicine, to relieve many inflammations, parts of Vernonia guineensis, are very widely used. This study considered the evaluation of acute toxicity and anti-inflammatory properties of the hydroethanolic extract of the roots of Vernonia guineensis. In an acute toxicity study, 250, 2500, and 5000 mg/kg were administered orally to mice in a single dose, and general behavior, adverse effects, and mortality were monitored. In vitro and in vivo anti-inflammatory tests were performed, and then histological, serum, hematological, and oxidative stress parameters have been evaluated. In an acute toxicity, all groups revealed neither mortality nor any significant alteration in behavior; only drowsiness, sedation, and lethargy were observed at 5000 mg/kg. For in vitro tests, the extract inhibited anti-inflammatory activity. In the formalin test, at 250 mg/kg, the extract inhibited edema with a percentage of 56.41% (4th hour) in an acute treatment and 74.44% (10th day). Joint edema was reduced by 67.24% (24th hour) in a single treatment and by 74.25% (7th day) in repeated treatment. The extract caused an increase in red blood cell, hemoglobin, and serum protein levels and reduced the white blood cells as well as the activities of alkaline phosphatase and alanine aminotransferase. The extract modulated oxidative stress parameters in the brain, spinal cord, liver, and kidneys. The extract protected the joint by reducing the bone and cartilage erosion. The present work highlights the anti-inflammatory, antioxidant, and antianemic properties of the hydroethanolic extract of the roots of Vernonia guineensis, which supports its empirical use in traditional medicine for the treatment of inflammatory pathologies.

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Section: Discussionmentioning

confidence: 99%