The clinical application of potentials evoked from the peripheral auditory system

Miller, Charles A.; Brown, Carolyn J.; Abbas, Paul J.; Chi, Siu-Ling

doi:10.1016/j.heares.2008.04.005

Cited by 106 publications

(87 citation statements)

References 73 publications

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“…A number of studies have indicated that cortical evoked potentials may be useful for predicting speech perception outcomes for CI subjects (Wable et al, 2000;Firszt et al, 2002;Kelly et al, 2005;Zhang et al, 2011), more so than earlier evoked potential responses such as auditory nerve electric compound action potentials (ECAPs) or auditory brainstem responses (Miller et al, 2008). However, two factors appear to have limited the clinical application of cortical evoked potentials for CI subjects.…”

Section: Clinical Application Of Laep To CI Usersmentioning

confidence: 99%

Cochlear implant artifact attenuation in late auditory evoked potentials: A single channel approach

et al. 2013

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a b s t r a c tRecent evidence suggests that late auditory evoked potentials (LAEP) provide a useful objective metric of performance in cochlear implant (CI) subjects. However, the CI produces a large electrical artifact that contaminates LAEP recordings and confounds their interpretation. Independent component analysis (ICA) has been used in combination with multi-channel recordings to effectively remove the artifact. The applicability of the ICA approach is limited when only single channel data are needed or available, as is often the case in both clinical and research settings. Here we developed a single-channel, high sample rate (125 kHz), and high bandwidth (0e100 kHz) acquisition system to reduce the CI stimulation artifact. We identified two different artifacts in the recording: 1) a high frequency artifact reflecting the stimulation pulse rate, and 2) a direct current (DC, or pedestal) artifact that showed a non-linear time varying relationship to pulse amplitude. This relationship was well described by a bivariate polynomial. The high frequency artifact was completely attenuated by a 35 Hz low-pass filter for all subjects (n ¼ 22). The DC artifact could be caused by an impedance mismatch. For 27% of subjects tested, no DC artifact was observed when electrode impedances were balanced to within 1 kU. For the remaining 73% of subjects, the pulse amplitude was used to estimate and then attenuate the DC artifact. Where measurements of pulse amplitude were not available (as with standard low sample rate systems), the DC artifact could be estimated from the stimulus envelope. The present artifact removal approach allows accurate measurement of LAEPs from CI subjects from single channel recordings, increasing their feasibility and utility as an accessible objective measure of CI function.

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Section: Clinical Application Of Laep To CI Usersmentioning

confidence: 99%

Cochlear implant artifact attenuation in late auditory evoked potentials: A single channel approach

et al. 2013

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“…This objective measure is an important clinical tool to assess the quality of the electrode-nerve interface of a CI recipient (Miller et al 2008). Routinely, the lowest stimulation level that evokes an eCAP ('threshold') is determined.…”

Section: Introductionmentioning

confidence: 99%

Assessing the Firing Properties of the Electrically Stimulated Auditory Nerve Using a Convolution Model

Strahl

Ramekers

Nagelkerke

et al. 2016

Advances in Experimental Medicine and Biology

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The electrically evoked compound action potential (eCAP) is a routinely performed measure of the auditory nerve in cochlear implant users. Using a convolution model of the eCAP, additional information about the neural firing properties can be obtained, which may provide relevant information about the health of the auditory nerve. In this study, guinea pigs with various degrees of nerve degeneration were used to directly relate firing properties to nerve histology. The same convolution model was applied on human eCAPs to examine similarities and ultimately to examine its clinical applicability. For most eCAPs, the estimated nerve firing probability was bimodal and could be parameterised by two Gaussian distributions with an average latency difference of 0.4 ms. The ratio of the scaling factors of the late and early component increased with neural degeneration in the guinea pig. This ratio decreased with stimulation intensity in humans. The latency of the early component decreased with neural degeneration in the guinea pig. Indirectly, this was observed in humans as well, assuming that the cochlear base exhibits more neural degeneration than the apex. Differences between guinea pigs and humans were observed, among other parameters, in the width of the early component: very robust in guinea pig, and 144 S. B. Strahl et al.dependent on stimulation intensity and cochlear region in humans. We conclude that the deconvolution of the eCAP is a valuable addition to existing analyses, in particular as it reveals two separate firing components in the auditory nerve.

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“…ABRs represent the status of the neural components (Miller, Brown, Abbas, & Chi, 2008;Montaguti, Bergonzoni, Zanetti, & Rinaldi Ceroni, 2007), whereas the CMs represent the status of the cochlear functions as they basically arise from the hair cells (Dallos, 1973;Eggermont, 1976;Ferraro & Durrant, 2002). In some disorders, the two types of responses…”

mentioning

confidence: 99%

Using Concha Electrodes to Measure Cochlear Microphonic Waveforms and Auditory Brainstem Responses

Zhang

2010

Trends in Amplification

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During electrocochleography, that is, ECochG or ECoG, a recording electrode can be placed in the ear canal lateral to the tympanic membrane. We designed a concha electrode to record both sinusoidal waveforms of cochlear microphonics (CMs) and auditory brainstem responses (ABRs). The amplitudes of CM waveforms and Wave I or compound action potentials (CAPs) recorded at the concha were greater than those recorded at the mastoid but slightly lower than those recorded at the ear canal. Wave V amplitudes recorded at the concha were greater than those recorded at the ear canal but lower than those recorded at the mastoid. There was not a significant difference between the amplitudes recorded at the concha and at the ear canal. For CM and Wave I or CAP, the latency recorded at the concha was longer than at the canal but shorter than at the mastoid; for Wave V, the reverse was true. However, these differences were not statistically significant and may be due to the distance to response generators. Aside from the advantages that the regular ECoG has over otoacoustic emission (OAE) testing, the concha electrode was also easier and safer to place and may be suitable for children, newborn screening, participants with canal conditions, and remote clinics which could have concerns with the availability and cost of a canal electrode. Using concha electrodes, we also experienced fewer postauricular artifacts than when using a mastoid electrode.

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The clinical application of potentials evoked from the peripheral auditory system

Cited by 106 publications

References 73 publications

Cochlear implant artifact attenuation in late auditory evoked potentials: A single channel approach

Cochlear implant artifact attenuation in late auditory evoked potentials: A single channel approach

Assessing the Firing Properties of the Electrically Stimulated Auditory Nerve Using a Convolution Model

Using Concha Electrodes to Measure Cochlear Microphonic Waveforms and Auditory Brainstem Responses

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