The Clinical Diagnosis of Autoimmune Bullous Diseases

Abstract

istanbul Üniversitesi istanbul Tip Fakültesi, Deri ve Zührevi Hastaliklar Anabilim Dali, istanbul, Türkiye ÖzetOtoimmun büllü hastaliklarin tanisi, henüz immunolojik tetkikler mevcut degilken klinik ve histopatolojik yöntemlerle konulmaktaydi. Ancak immünolojinin geli^mesiyle hastaliklarin klinik özellikleri degijmese de siniflamalari degijmijtir. Buna göre pemfigus grubu hastaliklar içinde pemfigus vulgaris, pemfigus vejetans, pemfigus foliaseus, pemfigus eritematozus, endemik pemfigus, IgA pemfigusu, pemfigus herpetiformis, paraneoplastik pemfigus ve ilaca bagli pemfigus yer almaktadir. Subepidermal büllü hastaliklar; pemfigoid grubu hastaliklar, edinsel epidermolizis bülloza, dermatitis herpetiformis ve lineer IgA dermatozu olarak siniflandirilmij olup bunlardan pemfigoid grubu içinde bülloz pemfigoid, çocukluk çaginin büllöz pemfigoidi, lokalize büllöz pemfigoid, ilaca bagli pemfigoid, anti p200 pemfigoid, gestasyonel pemfigoid, pemfigoid nodularis ve slkatrisyel pemfigoid yer almaktadir. Bu yazida, otoimmun büllü hastaliklarin klinik özellikleri, yukaridaki siniflamaya göre anlatilmistir Anahtar Kelimeler: Otoimmün büllöz hastaliklar, pemfigus, pemfigoid, edinsel epidermolizis bülloza, dermatitis herpetiformis, lineer IgA dermatozu, klinik tani SummaryThe autoimmune bullous diseases were diagnosed on the clinical and histopathological basis, before the introduction of the immunological assays. However, not the clinical features, but the classification of the diseases has recently changed during the immunological development. According to this new classification, pemphigus group diseases include, pemphigus vulgaris, pemphigus vegetans, pemphigus foliaceus, pemphigus erythematosus, endemic pemphigus, IgA pemphigus, pemphigus herpetiformis, paraneoplastic pemphigus, and drug-induced pemphigus. The subepidermal bullous diseases are classified as pemphigoid group diseases, epidermolysis bullosa acquisita, dermatitis herpetiformis, and linear IgA bullous dermatosis. The pemphigoid-group diseases consist of bullous pemphigoid, childhood bullous pemphigoid, localised bullous pemphigoid, drug-induced pemphigoid, anti p200 pemphigoid, pemphigoid gestationes, pemphigoid nodularis, and cicatricial pemphigoid. In this review, the clinical features of the autoimmune bullous diseases are discussed according to the above mentioned classification. (Turkderm 2010; 45 SuppI 1: 16-25)

Comorbidity profiles among patients with autoimmune bullous diseases; a retrospective study

“…In pemphigoid group disease, target antigens are localized in the dermoepidermal junction, whereas in DH, the target antigen is epidermal transglutaminase. [ 1 , 3 ]…”

“…In pemphigoid group disease, target antigens are localized in the dermoepidermal junction, whereas in DH, the target antigen is epidermal transglutaminase. [1,3] In the literature, there are many studies investigating the association of ABDs with other diseases, mainly autoimmune Objectives: The purpose of the present study was to define the accompanying diseases of patients with autoimmune bullous diseases (ABDs). Methods: One hundred forty-two patients with ABD who were followed up in the dermatology and venereology inpatient clinic of Şişli Hamidiye Etfal Training and Research Hospital between January 1999 and December 2015 were enrolled in the study.…”