The clinical diagnostic value of target biopsy using narrow‐band imaging endoscopy and accurate laryngeal carcinoma pathologic specimen acquisition

Yang, Yang; Liu, Jixiang; Song, Fucun

doi:10.1111/coa.12654

Cited by 12 publications

(13 citation statements)

References 35 publications

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“…Yang et al also studied the use of NBI and found NBI target pathology yielded an accurate laryngeal lesion pathologic specimen acquisition rate of 95.6% (65/68), significantly higher than that yielded by regular biopsy (75.7%, 53/70). 11 We have not done regular white light endoscopic biopsy due to ethical issues, but on comparison of our result to above mentioned study we can say that our result is in accordance with them. We can conclude that NBI directed biopsy yields more accurate lesion pathologic acquisition rate.…”

Section: Target Biopsysupporting

confidence: 83%

Demographics and targeted biopsy with NBI in head and neck mucosal lesions

Bhandari

Sachdeva

2020

Int J Otorhinolaryngol Head Neck Surg

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Background: It is estimated that by the end of year 2020 over 10 million people worldwide would die of cancer every year and about 66% of these would be from developing world like India (WHO-UCC 2003). Our aim in present study was to evaluate the use of targeted biopsy of mucosal lesions of head and neck cancer using narrow band imaging technique, in order to yield more accurate specimen of lesion which will result in correct diagnosis of disease early and to study different demographics of patients.Methods: Patients lesions were examined under NBI endoscope, best site of biopsy were identified on the basis of increase vascularity, neo-angiogenesis and superficial capillary vessels. Biopsy were taken from this site and sent for histopathological examinations. Considering histopathological report as standard, results from NBI endoscopy were compared to the results of previous studies and conclusion was done. We also studied different demographics of these patients under site of lesion, age distribution, sex distribution, and locality, histopathology type. Results: Maximum lesions were found in oral cavity (56.33%). Malignancy was also more common in oral cavity (63.46%), mostly belong to squamous cell carcinoma on histopathology. Mean age of presentation of head and neck mucosal lesion was found to be 48 year and of malignant lesions is 54 years.Conclusions: We conclude that up to an extent with progression of age malignant lesions increase. Male to female ratio of mucosal lesions is 1.7:1 and of malignancy is 2.25:1. Narrow band imaging endoscopy helps us to identify best site of biopsy, helping in early diagnosis of disease and ultimately reducing morbidity and mortality of patient.

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Section: Target Biopsysupporting

confidence: 83%

Demographics and targeted biopsy with NBI in head and neck mucosal lesions

Bhandari

Sachdeva

2020

Int J Otorhinolaryngol Head Neck Surg

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“…Similarly, even experienced endoscopists were bothered by the low accuracy of early detection of LCA and PRELCA in clinic practice as well through routine white-light endoscopy, especially for those intraepithelial and submucosal changes of the lesions [2,6]. Therefore, performance of current trained DCNN is inferior to that of NBI in detection of LCA and PRELCA, because the latter has a relatively high sensitivity and specificity in early detection of LCA by highlighting microsurface patterns and microvascular morphologies on the mucosal surface [2,5,8]. However, NBI is not always available in most rural areas of developing countries due to high costs of the equipments.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, endoscopic systems with narrow band imaging (NBI), which enhances the visualization of epithelial and subepithelial microvascular patterns, play a critical role in early detection of LCA with a high sensitivity of 88.9–97.0% at a high specificity of 84.6–96.0% [[4], [5], [6], [7], [8]]. Nevertheless, the use of NBI for diagnosis requires advanced magnifying endoscopes, specific training time and experienced endoscopists, which limits the clinical application of NBI endoscopy in many developing countries, including China.…”

Section: Introductionmentioning

confidence: 99%

Computer-aided diagnosis of laryngeal cancer via deep learning based on laryngoscopic images

et al. 2019

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ObjectiveTo develop a deep convolutional neural network (DCNN) that can automatically detect laryngeal cancer (LCA) in laryngoscopic images.MethodsA DCNN-based diagnostic system was constructed and trained using 13,721 laryngoscopic images of LCA, precancerous laryngeal lesions (PRELCA), benign laryngeal tumors (BLT) and normal tissues (NORM) from 2 tertiary hospitals in China, including 2293 from 206 LCA subjects, 1807 from 203 PRELCA subjects, 6448 from 774 BLT subjects and 3191 from 633 NORM subjects. An independent test set of 1176 laryngoscopic images from other 3 tertiary hospitals in China, including 132 from 44 LCA subjects, 129 from 43 PRELCA subjects, 504 from 168 BLT subjects and 411 from 137 NORM subjects, was applied to the constructed DCNN to evaluate its performance against experienced endoscopists.ResultsThe DCCN achieved a sensitivity of 0.731, a specificity of 0.922, an AUC of 0.922, and the overall accuracy of 0.867 for detecting LCA and PRELCA among all lesions and normal tissues. When compared to human experts in an independent test set, the DCCN’ s performance on detection of LCA and PRELCA achieved a sensitivity of 0.720, a specificity of 0.948, an AUC of 0.953, and the overall accuracy of 0.897, which was comparable to that of an experienced human expert with 10–20 years of work experience. Moreover, the overall accuracy of DCNN for detection of LCA was 0.773, which was also comparable to that of an experienced human expert with 10–20 years of work experience and exceeded the experts with less than 10 years of work experience.ConclusionsThe DCNN has high sensitivity and specificity for automated detection of LCA and PRELCA from BLT and NORM in laryngoscopic images. This novel and effective approach facilitates earlier diagnosis of early LCA, resulting in improved clinical outcomes and reducing the burden of endoscopists.

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“…It allows to trace the course of vascularisation of the described lesion and its location within the suspected area (e.g., swollen, changed mucosa), and thus determine whether the lesion may be malignant [5]. Traditional endoscopy is useful in the diagnosis of typical, often advanced pathological changes in the mucosa of the oral cavity, throat and larynx, but it shows limitations in relation to superficial, small neoplastic lesions [6]. Endoscopy with the use of Narrow Band Imaging is based on the modification of spectral properties of wave beam with the use of a special filter placed in the optical system.…”

mentioning

confidence: 99%

Comparative evaluation of the diagnostic value of biopsy and NBI endoscopy in patients with cancer of the hypopharynx and larynx

Wacławek

Miłoński

Olszewski³

2019

Otolaryngol Pol

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INTRODUCTION: Novel endoscopic technique - Narrow Band Imaging (NBI) seems to be a promising method for an early detection of neoplastic lesions of the upper aerodigestive tract. Compared to white light endoscopy, NBI improves the visualisation of the mucosal and submucosal microvascular patterns of observed pathologies. The aim of the study was to evaluate the diagnostic value of biopsy and NBI in patients with cancer of the larynx and hypopharynx. MATERIAL AND METHODS: The study was conducted in 100 adult subjects hospitalized in the Clinic of Otolaryngology, Laryngological Oncology, Audiology and Phoniatrics of Military Medical Academy University Teaching Hospital in Lodz, who were planned for surgical procedures for excision or surgical biopsy of pathological lesions of the hypopharynx or larynx. The following examinations were performed: subjective and objective, otorhinolaryngological, NBI endoscopy and histopathological assessment of suspicious lesions. The microvascular pattern of observed lesions was assessed according to the Ni scale criteria. The next stage of the study was to compare the endoscopic examination results (type of vascular pattern according to the Ni scale) with the histopathological result. The obtained results were subjected to statistical analysis. RESULTS: The sensitivity of NBI endoscopy in detection of malignant neoplasms in patients with hypopharynx and larynx lesions is 90.48%, specificity 91.14%, positive predictive value 73.08%, negative predictive value 97.30%. CONCLUSIONS: NBI endoscopy is a modern imaging method, increasing the diagnostic potential of endoscopy in the early detection of malignant lesions within the hypopharynx and larynx.

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The clinical diagnostic value of target biopsy using narrow‐band imaging endoscopy and accurate laryngeal carcinoma pathologic specimen acquisition

Abstract: In cases of laryngeal carcinoma, NBI endoscopy plays an important role in clinical diagnosis and accurate pathologic specimen acquisition and could be a regular clinical method for laryngeal lesion detection.

Cited by 12 publications

References 35 publications

Demographics and targeted biopsy with NBI in head and neck mucosal lesions

Demographics and targeted biopsy with NBI in head and neck mucosal lesions

Computer-aided diagnosis of laryngeal cancer via deep learning based on laryngoscopic images

Comparative evaluation of the diagnostic value of biopsy and NBI endoscopy in patients with cancer of the hypopharynx and larynx

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