The clinical efficacy of cosmeceutical application of liquid crystalline nanostructured dispersions of alpha lipoic acid as anti-wrinkle

Sherif, Saly; Bendas, Ehab R.; Badawy, Sabry

doi:10.1016/j.ejpb.2013.09.008

Cited by 86 publications

(39 citation statements)

References 28 publications

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“…These findings were further supported by Almgren and Rangelov who reported cubic nanostructured particles from aqueous dispersions of GMO (RYLO MG 90) in water, using DDP-PEG (DDP(EO) 52 or DDP(EO) 92 ) as the steric stabilizer [206]. However, cubosomes were also identified with an additional cubic phase Q 229 , with Im3m space group.…”

Section: 3-didodecyloxy-propane-2-ol and 13-didodecyloxy-2-glycidysupporting

confidence: 75%

Steric Stabilizers for Cubic Phase Lyotropic Liquid Crystal Nanodispersions (Cubosomes)

Chong

Mulet

Boyd

et al. 2015

Advances in Planar Lipid Bilayers and Liposomes

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Section: 3-didodecyloxy-propane-2-ol and 13-didodecyloxy-2-glycidysupporting

confidence: 75%

Steric Stabilizers for Cubic Phase Lyotropic Liquid Crystal Nanodispersions (Cubosomes)

Chong

Mulet

Boyd

et al. 2015

Advances in Planar Lipid Bilayers and Liposomes

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“…In addition, MGE was not recommended to prepare LC dry powder at a concentration of 20 or above. Zeta potential is an important parameter for the evaluation of stability and bio-distribution 18,19 . By increasing the MGE concentration, the particle size tended to be smaller and the zeta potential became more negative Table 3 , suggesting that the number of LC forming particles was increased with an increasing of MGE concentration.…”

Section: Discussionmentioning

confidence: 99%

Development and Optimization of Orally and Topically Applied Liquid Crystal Drug Formulations

et al. 2017

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“…One of the strategies to formulate this compound is as cubosomes, which are discrete, submicron, nanostructured particles of bicontinuous cubic liquid crystalline phase which are able to incorporate large amounts of drugs or actives [47]. A recent study has demonstrated that the formulation of ALA in cubosome dispersion has excellent results in reducing facial lines with almost complete resolution of fine lines in the periorbital region and upper lip area and an overall improvement in skin color and texture in most volunteers [48]. Table 1 shows different studies demonstrating that the use of nanoformaulation enhances the skin delivery of antioxidants.…”

Section: Nanocarriers For Other Antioxidantsmentioning

confidence: 99%

Nanocarriers for Delivery of Antioxidants on the Skin

Vinardell

Mitjans

2015

Cosmetics

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Skin is protected from the harmful effects of free radicals by the presence of an endogenous antioxidant system. However, when exposed to ultraviolet (UV) radiation, there is an imbalance between pro-oxidants and antioxidants, leading to oxidative stress and photoaging of the skin. It has been described that free radicals and other reactive species can cause severe damage to cells and cell components of the skin, which results in skin aging and cancer. To prevent these actions on skin, the use of topical antioxidant supplementation is a strategy used in the cosmetics industry and these antioxidants act on quenching free radicals. There are many studies that demonstrated the antioxidant activity of many phytochemicals or bioactive compounds by free radical scavenging. However, many bioactive substances are unstable when exposed to light or lose activity during storage. The potential sensitivity of these substances to light exposure is of importance in cosmetic formulations applied to skin because photo-degradation might occur, reducing their activity. One strategy to reduce this effect on the skin is the preparation of different types of nanomaterials that allow the encapsulation of the antioxidant substances. Another problem related to some antioxidants is their inefficient percutaneous penetration, which limits the amount of the active ingredient able to reach the site of action in viable epidermis and dermis. In this sense, the encapsulation in polymeric nanoparticles could enhance the permeation of these substances. Nanocarriers offers several advantages over conventional passive delivery, such as increased surface area, higher solubility, improved stability, controlled release, reduced skin irritancy, and protection from degradation. The different nanocarrier systems used in cosmetics include nanolipid delivery systems such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), nanoemulsions OPEN ACCESS Cosmetics 2015, 2 343 (NEs), nanoparticles (NP) suspension, and polymer NPs, among others. In this review, we present the different types of nanomaterials used in cosmetic formulations to obtain the best effect of antioxidants applied onto the skin.

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The clinical efficacy of cosmeceutical application of liquid crystalline nanostructured dispersions of alpha lipoic acid as anti-wrinkle

Cited by 86 publications

References 28 publications

Steric Stabilizers for Cubic Phase Lyotropic Liquid Crystal Nanodispersions (Cubosomes)

Steric Stabilizers for Cubic Phase Lyotropic Liquid Crystal Nanodispersions (Cubosomes)

Development and Optimization of Orally and Topically Applied Liquid Crystal Drug Formulations

Nanocarriers for Delivery of Antioxidants on the Skin

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