2011
DOI: 10.1038/bmt.2011.12
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The clinical features and outcome of 2009 H1N1 influenza infection in allo-SCT patients: a British Society of Blood and Marrow Transplantation study

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Cited by 23 publications
(21 citation statements)
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“…Similar to our study, the mortality associated with pandemic influenza ranges from 5% to 33%. The rate of development of LRTI with A(H1N1)pdm09 (32.4%) is similar to that previously described with seasonal influenza as well as A(H1N1)pdm09 in this population . Previous studies have noted lymphopenia as a risk factor for influenza or related complications; however, the definition of lymphopenia varies from <100 to <1000 cells/μL .…”
Section: Discussionsupporting
confidence: 83%
“…Similar to our study, the mortality associated with pandemic influenza ranges from 5% to 33%. The rate of development of LRTI with A(H1N1)pdm09 (32.4%) is similar to that previously described with seasonal influenza as well as A(H1N1)pdm09 in this population . Previous studies have noted lymphopenia as a risk factor for influenza or related complications; however, the definition of lymphopenia varies from <100 to <1000 cells/μL .…”
Section: Discussionsupporting
confidence: 83%
“…Factors associated with severe disease included profound lymphopenia, increasing age, preexisting lung disease, bacterial co-infection, and delayed antivirals >48 hours after initial symptoms [93, 96, 114-119]. A recent study in HCT recipients found that, although there was no difference in mortality, pH1N1 infection was significantly associated with pneumonia, hypoxemia, and prolonged viral shedding compared with seasonal influenza A [93].…”
Section: Pandemic Influenza A/h1n1 and Transplant Recipientsmentioning
confidence: 99%
“…(10, 11) Previous studies have revealed various risk factors for influenza-associated LRI in HCT recipients, such as lymphocytopenia, nosocomial acquisition of the virus, older age, and preexisting lung disease. (1214) Using these clinically available risk factors, an immunodeficiency scoring index (ISI) was developed in HCT recipients with respiratory syncytial virus (RSV) infections to help identify patients at higher risk for complications and those who would benefit the most from antiviral therapy. (15) As this scoring index was not based on virus-specific factors, it may be extrapolated to other respiratory viruses, such as influenza, in HCT recipients.…”
Section: Introductionmentioning
confidence: 99%