The clinical features of papillary thyroid cancer in Hashimoto’s thyroiditis patients from an area with a high prevalence of Hashimoto’s disease

Zhang, Ling; Li, Hui; Ji, Qing; Zhu, Yong; Wang, Zhuo Ying; Wang, Yu; Huang, Chenlu; Shen, Qiang; Li, Duan Shu; Wu, Yi Long

doi:10.1186/1471-2407-12-610

Cited by 93 publications

(74 citation statements)

References 45 publications

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“…Since the association between CLT and PTC was reported in 1955 (Dailey et al 1955), many authors have reported that there is an increased risk of developing PTC in those with preexisting CLT (Zhang et al 2012, Lee et al 2013a. On the other hand, some investigators have reported that PTC with the coexistence of CLT is less associated with ETE, advanced stage, LN metastasis and recurrence (Loh et al 1999, Kim et al 2009a, Lang et al 2014.…”

Section: Introductionmentioning

confidence: 99%

Chronic lymphocytic thyroiditis and BRAF V600E in papillary thyroid carcinoma

Kim¹,

Woo²,

Lee³

et al. 2015

Endocrine-Related Cancer

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It has been reported that papillary thyroid carcinoma (PTC) with chronic lymphocytic thyroiditis (CLT) is less associated with extrathyroidal extension (ETE), advanced tumor stage and lymph node (LN) metastasis. Other studies have suggested that concurrent CLT could antagonize PTC progression, even in BRAF-positive patients. Since the clinical significance of the BRAF mutation has been particularly associated with conventional PTC, the purpose of this study was to determine the clinical significance of CLT according to BRAF mutation status in conventional PTC patients. We retrospectively reviewed the medical records of 3332 conventional PTC patients who underwent total thyroidectomy with bilateral central neck dissection at the Thyroid Cancer Center of Samsung Medical Center between January 2008 and June 2015. In this study, the prevalence of BRAF mutation was significantly less frequent in conventional PTC patients with CLT (76.9% vs 86.6%). CLT was an independent predictor for low prevalence of ETE in both BRAF-negative (ORZ0.662, PZ0.023) and BRAF-positive (ORZ0.817, PZ0.027) conventional PTC patients. In addition, CLT was an independent predictor for low prevalence of CLNM in both BRAF-negative (ORZ0.675, PZ0.044) and BRAF-positive (ORZ0.817, PZ0.030) conventional PTC patients. In conclusion, BRAF mutation was significantly less frequent in conventional PTC patients with CLT. However, CLT was an independent predictor for less aggressiveness in conventional PTC patients regardless of BRAF mutation status. Key Words" BRAF mutation " papillary thyroid carcinoma " chronic lymphocytic thyroiditis " central lymph node metastasis " extrathyroidal extension

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Section: Introductionmentioning

confidence: 99%

Chronic lymphocytic thyroiditis and BRAF V600E in papillary thyroid carcinoma

Kim¹,

Woo²,

Lee³

et al. 2015

Endocrine-Related Cancer

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“…Several analyses of surgical resection specimens have shown that PTC is frequently accompanied by HT. Interestingly, PTC with HT is associated with a lower rate of neck lymph node metastasis and has a better prognosis than PTC without thyroiditis in spite of increased incidence correlation [1][2][3][4][5][6][7][8][9][10]. In contrast, other studies conducted by fine-needle aspiration biopsy specimens and ultrasonographic findings have found no correlation between the incidences of these two diseases, with researchers insisting that HT does not increase the risk of thyroid…”

mentioning

confidence: 71%

Genomic evidence of reactive oxygen species elevation in papillary thyroid carcinoma with Hashimoto thyroiditis

Park

Sung

et al. 2015

Endocr J

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Abstract. Elevated levels of reactive oxygen species (ROS) have been proposed as a risk factor for the development of papillary thyroid carcinoma (PTC) in patients with Hashimoto thyroiditis (HT). However, it has yet to be proven that the total levels of ROS are sufficiently increased to contribute to carcinogenesis. We hypothesized that if the ROS levels were increased in HT, ROS-related genes would also be differently expressed in PTC with HT. To find differentially expressed genes (DEGs) we analyzed data from the Cancer Genomic Atlas, gene expression data from RNA sequencing: 33 from normal thyroid tissue, 232 from PTC without HT, and 60 from PTC with HT. We prepared 402 ROS-related genes from three gene sets by genomic database searching. We also analyzed a public microarray data to validate our results. Thirtythree ROS related genes were up-regulated in PTC with HT, whereas there were only nine genes in PTC without HT (Chisquare p-value < 0.001). Mean log 2 fold changes of up-regulated genes was 0.562 in HT group and 0.252 in PTC without HT group (t-test p-value = 0.001). In microarray data analysis, 12 of 32 ROS-related genes showed the same differential expression pattern with statistical significance. In gene ontology analysis, up-regulated ROS-related genes were related with ROS metabolism and apoptosis. Immune function-related and carcinogenesis-related gene sets were enriched only in HT group in Gene Set Enrichment Analysis. Our results suggested that ROS levels may be increased in PTC with HT. Increased levels of ROS may contribute to PTC development in patients with HT.Key words: Reactive oxygen species, Thyroid cancer, Hashimoto thyroiditis, Gene expression, Bioinformatics illary thyroid carcinoma (PTC) has been extensively studied, but the precise relationship between these two diseases is still being debated. Several analyses of surgical resection specimens have shown that PTC is frequently accompanied by HT. Interestingly, PTC with HT is associated with a lower rate of neck lymph node metastasis and has a better prognosis than PTC without thyroiditis in spite of increased incidence correlation [1][2][3][4][5][6][7][8][9][10]. In contrast, other studies conducted by fine-needle aspiration biopsy specimens and ultrasonographic findings have found no correlation between the incidences of these two diseases, with researchers insisting that HT does not increase the risk of thyroid Original

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“…More PTC was found in those with HT than those without HT (58.3 % vs 44.3%; p<0.05), emphasizing the close relationship between these 2 disorders [12].…”

Section: Hashimoto's Thyroiditis and Papillary Thyroid Cancermentioning

confidence: 85%

Hashimoto’s Thyroiditis And Cancer: A Review

Salti

2017

int arch med

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Background: No consensus exists on the association betweenHashimoto's thyroiditis (HT) and cancer. To resolve this controversy, this review aimed to evaluate the relationship between the two conditions. Methods:Using pub-med database, we searched studies relevant to the topic focusing on the association between HT and papillary thyroid cancer (PTC), as well as the association between HT and primary thyroid lymphoma (PTL).Findings: Both HT and PTC are common worldwide, and the two conditions may be closely related. However, the relationship remains controversial. Some studies found that PTC coexisted with HT 2.8-fold more frequently, with variable prevalence ranging from 0.5 to 30%. In contrast to surgical and pathological series that suggested a positive correlation between the two diseases and even a cause-and-effect relationship, the other studies evaluating fine-needle aspirate specimens did not find a statistically significant correlation. On the other hand, the relationship between PTL and HT appears well established. Conclusion:The existing data provide inconsistent evidence favoring a causal relationship between HT and PTC. Prospective studies are needed to further elucidate the relationship. However patients with HT are at risk for PTL. Therefore careful observation and follow-up of HT patients is recommended.

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The clinical features of papillary thyroid cancer in Hashimoto’s thyroiditis patients from an area with a high prevalence of Hashimoto’s disease

Cited by 93 publications

References 45 publications

Chronic lymphocytic thyroiditis and BRAF V600E in papillary thyroid carcinoma

Chronic lymphocytic thyroiditis and BRAF V600E in papillary thyroid carcinoma

Genomic evidence of reactive oxygen species elevation in papillary thyroid carcinoma with Hashimoto thyroiditis

Hashimoto’s Thyroiditis And Cancer: A Review

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