The clinical impact of antibacterial prophylaxis and cycling antibiotics for febrile neutropenia in a hematological malignancy and transplantation unit

Craig, Michael; Cumpston, Aaron; Hobbs, Gerry; Devetten, Marcel P.; Sarwari, Arif R.; Ericson, Solveig G.

doi:10.1038/sj.bmt.1705591

Cited by 59 publications

(33 citation statements)

References 19 publications

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“…The results of other studies showed that this strategy was effective in managing microbial resistance within individuals and populations, in particular for patients hospitalized in the intensive care unit [19][20][21][22].…”

Section: Preventive Strategies With a Continuous Antibiotic Treatmentmentioning

confidence: 99%

Prevention of urinary tract infections by antibiotic cycling in spinal cord injury patients and low emergence of multidrug resistant bacteria

Poirier

Dinh²,

Salomon³

et al. 2016

Médecine et Maladies Infectieuses

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Section: Preventive Strategies With a Continuous Antibiotic Treatmentmentioning

confidence: 99%

Prevention of urinary tract infections by antibiotic cycling in spinal cord injury patients and low emergence of multidrug resistant bacteria

Poirier

Dinh²,

Salomon³

et al. 2016

Médecine et Maladies Infectieuses

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“…We previously reported that the detection rate of Enterococcus strains in bacteremic isolates was significantly higher in patients with quinolone prophylaxis than in those without prophylaxis 22. Interestingly, the increase of bacteremic VRE isolates after quinolone prophylaxis was also reported from an institute in the United States 23. In the highly endemic areas of VRE, quinolone prophylaxis might affect the detection rates of their bacteremia in patients with febrile neutropenia.…”

Section: Discussionmentioning

confidence: 85%

Incomplete recovery of the fecal flora of hematological patients with neutropenia and repeated fluoroquinolone prophylaxis

Chong

Shimoda

Miyake

et al. 2017

IDR

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BackgroundRoutine fluoroquinolone prophylaxis in neutropenic patients with hematological malignancies is still controversial, because of antibiotic resistance concerns. The recovery of the fecal microbiota to the initial composition in patients receiving multiple courses of quinolone prophylaxis and repeated chemotherapy has not been evaluated.MethodsWe prospectively examined the changes in the fecal bacterial composition before and after levofloxacin prophylaxis. A sequential observation of bacterial resistance in patients receiving multiple prophylactic courses was also conducted.ResultsIn this trial, 68 cases, including (35 with the first course and 33 with the second and subsequent courses) were registered. The disappearance of quinolone-susceptible (QS) Entero-bacteriaceae and dominant emergence of quinolone-resistant (QR) coagulase negative staphylococci (CNS) and QR Enterococci were observed after the first prophylaxis. The detection of QS Enterobacteriaceae was recovered before the second and subsequent courses to a level of the initial composition (28/35 samples, 80.0% before the first course vs 23/33 samples, 69.7% before the second and subsequent courses, P=0.41). In contrast, the detection rate of QR CNS and Enterococci significantly increased at the second and subsequent courses, even before prophylaxis (8/35 samples, 22.9% before the first course vs 20/33 samples, 60.6% before the second and subsequent courses, P=0.003). The incomplete recovery of the initial bacterial composition was associated with a prophylactic interval of within 30 days. Of the patients receiving multiple prophylactic courses, six had QR Escherichia coli, including extended-spectrum β-lactamase (ESBL) producers, at the first course, and four (66.3%) of the six patients had persistent detection of QR E. coli at the second course.ConclusionIn patients receiving multiple courses of prophylactic quinolone, along with a common chemotherapy schedule, newly emergent resistant bacteria could be frequently persistent in their fecal flora.

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“…The regimens of HDT in NHL patients are not the same between the two groups. The chronological differences may also affect the predominant strain at each transplantation [39]. We had a small number of CDIs (one skin infection, two pulmonary infiltrations with symptoms).…”

Section: Discussionmentioning

confidence: 94%

The role of prophylactic antimicrobials during autologous stem cell transplantation: a single-center experience

Sohn

Yoon

Kim

et al. 2011

Eur J Clin Microbiol Infect Dis

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The aim of this study was to investigate the efficacy of antibiotic prophylaxis in patients undergoing autologous stem cell transplantation (ASCT) for multiple myeloma and non-Hodgkin lymphoma. Among 232 ASCT cases performed at the Asan Medical Center, 114 cases underwent treatment with ciprofloxacin, fluconazole, and acyclovir (between January 2001 and August 2005), while 118 cases were performed without antimicrobial prophylaxis (between February 2004 and June 2008). The two-rate χ2 test was applied to accommodate the differences in neutropenia duration. The incidence of febrile episodes was 9.8 cases per 100 person-days in the prophylactic group, while it was 16.2 cases in the no-prophylactic group (p<0.001). The rate of unexplained fever was 8.0 cases per 100 person-days in the prophylactic group, while it was 13.8 cases in the no-prophylactic group (p<0.001). The rate of clinically and microbiologically documented infection was 1.7 cases per 100 person-days in the prophylactic group, while it was 2.3 cases in the no-prophylactic group (p=0.404). There were fewer cases of methicillin-susceptible Staphylococcus aureus infection and a greater number of quinolone-resistant Escherichia coli in the prophylactic group compared with the no-prophylactic group (p=0.056 and p=0.040, respectively). The prophylactic antimicrobials reduced the incidence rate of febrile episodes, especially unexplained fever, despite there being no difference in the incidence of documented infection. Resistant microbe infection occurred more frequently in the prophylactic group.

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The clinical impact of antibacterial prophylaxis and cycling antibiotics for febrile neutropenia in a hematological malignancy and transplantation unit

Cited by 59 publications

References 19 publications

Prevention of urinary tract infections by antibiotic cycling in spinal cord injury patients and low emergence of multidrug resistant bacteria

Prevention of urinary tract infections by antibiotic cycling in spinal cord injury patients and low emergence of multidrug resistant bacteria

Incomplete recovery of the fecal flora of hematological patients with neutropenia and repeated fluoroquinolone prophylaxis

The role of prophylactic antimicrobials during autologous stem cell transplantation: a single-center experience

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