The clinical impact of drug-induced hepatotoxicity on anti-tuberculosis therapy: a case control study

Song, Jin Hwa; Yoon, Seo Young; Park, Tae Yun; Heo, Eun Young; Kim, Deog Kyeom; Chung, Ha Sook; Lee, Jung Kyu

doi:10.1186/s12931-019-1256-y

Cited by 15 publications

(8 citation statements)

References 25 publications

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“…In 1994, morphological damage of myocardial mitochondria in septic cardiomyopathy was first described in an animal model ( 26 ). Studies have shown that the ultra-microstructural abnormalities of myocardial mitochondria in septic cardiomyopathy include swelling, ridge loss, matrix clearance, rupture of internal vesicles, and damage to internal and external membranes ( 27 , 28 ), which are closely related to mitochondrial dysfunction ( 29 ). Specifically, ultra-microstructural abnormalities lead to the destruction of the OXPHOS process and further reduce adenosine triphosphate (ATP) production.…”

Section: Mitochondrial Ultrastructural Damage and Decreased Atp Productionmentioning

confidence: 99%

Roles of LncRNAs in Regulating Mitochondrial Dysfunction in Septic Cardiomyopathy

Liu

Wang

2021

Front. Immunol.

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Sepsis is an abnormal systemic inflammatory response of the host immune system to infection and can lead to fatal multiorgan dysfunction syndrome. Epidemiological studies have shown that approximately 10-70% of sepsis cases can lead to septic cardiomyopathy. Since the pathogenesis of septic cardiomyopathy is not clear, it is difficult for medical doctors to treat the disease. Therefore, finding effective interventions to prevent and reduce myocardial damage in septic cardiomyopathy is clinically significant. Epigenetics is the study of stable genetic phenotype inheritance that does not involve changing gene sequences. Epigenetic inheritance is affected by both gene and environmental regulation. Epigenetic studies focus on the modification and influence of chromatin structure, mainly including chromatin remodelling, DNA methylation, histone modification and noncoding RNA (ncRNA)-related mechanisms. Recently, long ncRNA (lncRNA)-related mechanisms have been the focus of epigenetic studies. LncRNAs are expected to become important targets to prevent, diagnose and treat human diseases. As the energy metabolism centre of cells, mitochondria are important targets in septic cardiomyopathy. Intervention measures to prevent and treat mitochondrial damage are of great significance for improving the prognosis of septic cardiomyopathy. LncRNAs play important roles in life activities. Recently, studies have focused on the involvement of lncRNAs in regulating mitochondrial dysfunction. However, few studies have revealed the involvement of lncRNAs in regulating mitochondrial dysfunction in septic cardiomyopathy. In this article, we briefly review recent research in this area.

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Section: Mitochondrial Ultrastructural Damage and Decreased Atp Productionmentioning

confidence: 99%

Roles of LncRNAs in Regulating Mitochondrial Dysfunction in Septic Cardiomyopathy

Liu

Wang

2021

Front. Immunol.

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“…Long-term use can cause side effects such as skin reaction, gastrointestinal dysfunction, and neurological dysfunction. 8,9 Hepatotoxicity is a side effect that most type of first-line ANTI-TB DRUG has. This effect also has the most serious impact.…”

Section: Introductionmentioning

confidence: 99%

“…Grade I is marked by an increase of ALT > 1.25 -≤ 3x normal, grade II increase > 3 -≤ 5x normal, grade III ALT increase > 5 -≤ 10x normal, and grade IV if ALT increase > 10x normal. 5,8 Studies conducted in several countries found that the incidence of anti-TB drug-induced hepatotoxicity varies. For example, a study in Nepal showed a prevalence of anti-TB drug-induced hepatotoxicity of 38%, while in Iran, the prevalence of anti-TB druginduced hepatotoxicity reaches 27%.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and Onset of Hepatotoxicity Caused by Anti-Tuberculosis Drugs on Pulmonary TB Patients in Wangaya General Hospital Denpasar – Bali in 2016

Yustin

Kusumawardani

Candrawati

et al. 2022

Heme

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Introduction: As tuberculosis (TB) endemic country, TB becomes a community health problem in Indonesia. Data from the Global TB Report in 2016 showed that Indonesia is the second most country with TB burden after India. WHO and the Ministry of Health issue a TB prevention program based on the End TB Strategy aimed to reduce morbidity, mortality, and disability due to TB. One of the challenges faced in the management of TB is the side effects of the anti-tuberculosis drug. Hepatotoxicity is the most common side effect. Aims: This study aims to determine the prevalence and onset of anti-TB drug-induced hepatotoxicity in TB patients after receiving the anti-TB drug in Wangaya Hospital Denpasar Bali. Method: This study used a cross-sectional method by obtaining secondary data of pulmonary TB patients visiting the pulmonary clinic in Wangaya General Hospital from January to December 2016. Result: Of 77 subjects, fifty-six percent of them were men. The highest prevalence was found in the 41-50 years age group (26.9%), while the lowest was found in the 81-90 years age group (1.2%). Anti-TB drug-induced hepatotoxicity occurred in 6.5% of subjects. The most frequent onset of hepatotoxicity occurred within the second week of medication. Anti-TB drug-induced hepatotoxicity occurred in 6.5% of subjects. The most frequent onset of hepatotoxicity occurred within the second week of medication. Conclusion: Based on this study, we suggest a liver function test before and after two weeks of an anti-TB drug.

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“…Hepatotoxicity is one of the adverse effects of ATD that could contribute to treatment interruption and may increase the risk of acquired resistance 4 . Some of the first-line ATD, isoniazid (H), rifampicin (R), and pyrazinamide (Z) are metabolized in the liver and have the potential to cause hepatotoxicity 5,6 .…”

Section: Introductionmentioning

confidence: 99%

Tuberculous Pyopneumothorax as A Complication of Inadequate Treatment in Active Pulmonary Tuberculosis: A Case Report

Maranatha¹,

Bahri²

2020

J Pure Appl Microbiol

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Various factors in tuberculosis (tB) management can cause inadequate treatment or failures in therapy. Drug-induced hepatotoxicity is one of the adverse effects of anti-tuberculosis drugs (ATD), which can reduce the effectiveness of treatment. Pneumothorax, empyema, and pyopneumothorax are complications of pulmonary tuberculosis, whilst infrequent but leading to significant morbidity and mortality. A 24-year-old woman came with the main complaint of shortness of breath. she was referred with pulmonary TB, right-side pneumothorax, and drug-induced liver injury (DILI) related to ATD. After DILI resolved, standard 6-month treatment (2HRZE/4HR) was continued, but the patient experienced nausea, vomiting, icteric sclera, and an elevation of transaminases. The combination of ATD was discontinued, just ethambutol and streptomycin were given until the transaminases improved. Afterward, the patient was given isoniazid (H), rifampicin (R), and ethambutol (E). The following week an elevation of transaminases was seen, all ATD was discontinued and the patient was given hepatoprotective therapy. After DILI resolved, a regimen of isoniazid (H), pyrazinamide (Z), ethambutol (E) were given. Later in the follow-up chest X-ray, there was worsening homogeneous opacity in the right hemithorax. Pus was observed on thoracentesis and chest tube was inserted for drainage. We presented a case of a pulmonary TB patient with hydropneumothorax having episodes of drug-induced liver injury. The hepatotoxicity related to ATD leads to repetitive discontinuation and change of regiment, resulting in inadequate therapy in the intensive phase of tuberculosis therapy which resulted in pyopneumothorax.

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The clinical impact of drug-induced hepatotoxicity on anti-tuberculosis therapy: a case control study

Cited by 15 publications

References 25 publications

Roles of LncRNAs in Regulating Mitochondrial Dysfunction in Septic Cardiomyopathy

Roles of LncRNAs in Regulating Mitochondrial Dysfunction in Septic Cardiomyopathy

Prevalence and Onset of Hepatotoxicity Caused by Anti-Tuberculosis Drugs on Pulmonary TB Patients in Wangaya General Hospital Denpasar – Bali in 2016

Tuberculous Pyopneumothorax as A Complication of Inadequate Treatment in Active Pulmonary Tuberculosis: A Case Report

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