The clinical significance of pancreatic steatosis

Abstract

More research is now focused on pancreatic steatosis. Multiple definitions, clinical associations and synonyms for pancreatic steatosis are described in the literature and can be confusing. The integration and comparison of several studies concerning this topic is therefore challenging. In the past, pancreatic steatosis was considered an innocuous condition, a bystander of many underlying diseases (such as congenital syndromes, hemochromatosis and viral infection). However, evidence that pancreatic steatosis (strongly associated with obesity and the metabolic syndrome) has a role in type 2 diabetes mellitus, pancreatic exocrine dysfunction, acute pancreatitis, pancreatic cancer and the formation of pancreatic fistula after pancreatic surgery is emerging. This Review focuses on the different etiological factors and the clinical consequences of pancreatic steatosis.

Клініко-Лабораторні Особливості Стеатозу Підшлункової Залози У Дітей З Надлишковою Вагою Та ожирінням

“…Неалкогольна жирова хвороба підшлункової залози (НАЖХПЗ) -це патологічний стан, асоційо-ваний з ожирінням та компонентами метаболічного синдрому. Морфологічним підґрунтям НАЖХПЗ є сте-атоз підшлункової залози (ПЗ), що передбачає нако-пичення жиру в адипоцитах без заміщення ацинарних та острівцевих клітин, що зумовлює оборотність про-цесу [8,9].…”

Pancreatic steatosis: diagnosis and clinical significance

“…Yapılan birçok çalışmada PS'un obezite, tip 2 DM, metabolik sendrom, NAFLD, NASH gibi hastalıklar ile ilişkisi olduğuna dair bulgular elde edilmiş olmakla birlikte obezite dışındaki diğer hastalıklarla arasında bir neden-sonuç ilişkisi olup olmadığı ve PS'un klinik önemi tam olarak ortaya konulamamıştır (25)(26)(27)(28).…”

Nonalcoholic fatty pancreas disease as an endogenous alcoholic fatty pancreas disease

“…In addition, NAFLD patients produce significantly more endogenous ethanol (EE) than controls, suggesting that it plays an important role in its pathogenesis [26][27][28][29][30][31][32]. Thus, as NAFPD is closely linked to NAFLD and NAFLD-related conditions [1,5,10,[33][34][35], it follows that EE can also exert a relevant role in the pancreatic injury. Taken together, these data allow us to hypothesize that NAFPD and AFPD are the same disease with different clinical presentations.…”

“…It is known that NAFPD shares with alcoholic fatty pancreas disease (AFPD) similar metabolic pathways [3, [13][14][15][16], as well as histopathological features [1,3,4,[17][18][19][20][21][22][23][24][25]. In addition, NAFLD patients produce significantly more endogenous ethanol (EE) than controls, suggesting that it plays an important role in its pathogenesis [26][27][28][29][30][31][32].…”

“…Nonalcoholic fatty pancreas disease (NAFPD) is a broad-spectrum disorder ranging from simple pancreatic steatosis to acute and chronic fibrosing nonalcoholic steatopancreatitis (NASP) and pancreatic cancer [1][2][3][4]. There are two distinct forms of this disease: primary or obesity-associated NAFPD, and secondary forms, which are linked to congenital syndromes, toxic agents, medications, viruses, and severe malnutrition [5].…”