The Clinical Significance of Positive Blood Cultures: A Comprehensive Analysis of 500 Episodes of Bacteremia and Fungemia in Adults. I. Laboratory and Epidemiologic Observations

Sepsis in head and neck cancer patients treated with chemotherapy and radiation: Literature review and consensus

“…Considering that the first antimicrobial dose can rapidly sterilize blood cultures within a few hours, obtaining those cultures before therapy is essential. Thus, at least two blood cultures, both peripherally and via indwelling catheters are recommended [70,[72][73][74]. Although some guidelines [70] recommend that cultures should not cause significant delay (>45 min) in starting antimicrobial administration, some authors suggest that non-neutropenic and stable patients should be observed without empirical antibiotics while considering further diagnostic evaluation [75].…”

Current Definitions of Central Line–Associated Bloodstream Infection Is the Emperor Wearing Clothes?

“…[13][14][15] Indeed, infectious diseases specialists routinely perform a repeat blood culture as a first step to assess patients who have a single blood culture positive for enterococci. If the repeat culture result is negative, most infectious diseases specialists would conclude that the single positive blood culture result represents contamination.…”

Course and Outcome of Bacteremia Due to Staphylococcus aureus: Evaluation of Different Clinical Case Definitions

“…Acquisition. Bacteremia was judged to be community acquired (CA) when the positive culture results were obtained at or within 48 hours after admission or when there was evidence of S. aureus infection on admission [10,[16][17][18]. Bacteremia was judged to be hospital acquired (HA) when the positive culture results were obtained >48 hours after hospitalization.…”

“…Previous hospitalization within 30 days of onset of illness was viewed as predisposing the patient to septicemia [21]. Other conditions frequently cited as predisposing factors to infection (table 1) were established as being either present or absent in each episode [4,5,10,16,[20][21][22][23][24][25][26][27][28][29][30][31].…”