The Clinical Use of Urecholine in Dysfunctions of the Bladder

Lee, Leroy William

doi:10.1016/s0022-5347(17)68925-0

Cited by 26 publications

(3 citation statements)

References 3 publications

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“…There have been also several attempts [Lee, 1949;Sonda et al, 1979;Wein et al, 1980al to document objectively changes in bladder activity in normal man after subcutaneous administration of bethanechol (2-5 mg). There seems to be unanimous agreement that bladder capacity is reduced and Lee [ 19491 reported a reduced volume at first desire to void.…”

Section: Effect After Subcutaneous Injectionmentioning

confidence: 99%

“…The bladder pressures during filling and at capacity are increased at least at the 4-5-mg dose. Voiding pressure also seems to be increased [Lee, 1949;Sonda et al, 19791, although the studies show increase [Sonda et al, 19791 or no change [Wein et al, 1980al in peak urine flow. Neither group showed a change in average flow rate.…”

Section: Effect After Subcutaneous Injectionmentioning

confidence: 99%

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Bethanechol chloride in urology—A discussion of issues

Downie

1984

Neurourology and Urodynamics

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The widespread and long-standing use of bethanechol chloride in urology attests as much to the lack of a suitable alternative as it does to the drug's perceived efficacy. The bases for both positive and negative conclusions about bethanechol's usefulness are critically examined and areas of controversy and uncertainty highlighted. An attempt is made to rationalize bethanechol's effects in the light of recent investigations into its mechanism of action but clearly more information is required for a full understanding of the drug's action and its' appropriate place in urologic practice.

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Section: Effect After Subcutaneous Injectionmentioning

confidence: 99%

Section: Effect After Subcutaneous Injectionmentioning

confidence: 99%

Bethanechol chloride in urology—A discussion of issues

Downie

1984

Neurourology and Urodynamics

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“…Cystometric investigations on dogs performed by Rose & Deakin (1928) and Winter (1941) showed that acetylcholine and choline derivates decreased the bladder capacity, whereas possible alterations in the bladder pressure were left uncommented. In the normal human bladder, Lee (1949) found increased intravesical pressure and reduced capacity on urecholine. The effect of carbacholine on uninhibited bladders has to my knowledge not yet been investigated.…”

mentioning

confidence: 94%

Pharmacological studies of the uninhibited neurogenic bladder

Jensen

2009

Acta Neurologica Scandinavica

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In order to elucidate the parasympathetic activity of the uninhibited neurogenic bladder, controlled cystometry before and during influence of cholinergic and anticholinergic drugs has been performed on patients with normal and uninhibited neurogenic bladder. Cholinergic stimulation proved to increase the intravesical pressure to a great extent; to a higher degree in the normal than in the uninhibited bladder. In two patients with normal bladder, uninhibited detrusor contractions were induced by cholinergic stimulation. Cholinergic inhibition had only minor influence on the intravesical pressure during the filling phase. Opposite effects were obtained on the uninhibited detrusor contractions which are regarded as a part of the expulsive phase. Cholinergic stimulation increased the amplitude of the uninhibited bladder to some degree, but cholinergic inhibition markedly reduce the amplitude. Conclusively, the uninhibited neurogenic bladder is at least partly caused by an overactivity in cholinergic stimulation.

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Pharmacological Treatment of Non-neurogenic Voiding Dysfunction

Wein¹

1984

Clinical Practice in Urology

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The Clinical Use of Urecholine in Dysfunctions of the Bladder

Cited by 26 publications

References 3 publications

Bethanechol chloride in urology—A discussion of issues

Bethanechol chloride in urology—A discussion of issues

Pharmacological studies of the uninhibited neurogenic bladder

Pharmacological Treatment of Non-neurogenic Voiding Dysfunction

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