The Clinical Uses of Electrocochleography

Gibson, W. P. R.

doi:10.3389/fnins.2017.00274

Cited by 38 publications

(31 citation statements)

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“…However, Ohashi and others found that an elevated SP/AP ratio of ECochG is maintained over an extended period of time and despite medical and surgical treatment (Ohashi et al 1991). Thus, it appears that the ECochG SP/AP ratio only indicates EHs and it is not necessarily correlated with MD symptoms (Gibson 2017). This is consistent with the findings of temporal bone studies that found the presence of hydrops does not necessarily correlate with MD symptoms (Merchant, Adams, and Nadol 2005;Rauch, Merchant, and Thedinger 1989).…”

Section: Introductionsupporting

confidence: 59%

Comparing the sensitivity and specificity of cervical vestibular-evoked myogenic potentials and electrocochleography in the diagnosis of Ménière’s disease

Obeidat

Bell

2019

International Journal of Audiology

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Objective: To compare the sensitivity and specificity of objective cervical vestibular-evoked myogenic potential (cVEMP) tuning curves and electrocochleography (ECochG) for the diagnosis of M eni ere's disease (MD). Design: Sensitivity and specificity were calculated from 95% normative ranges of 500 Hz cVEMP threshold and ECochG SP/AP amplitude ratios. Measures: Extra-tympanic ECochG testing to 90 dB nHL clicks and cVEMP threshold tuning curves (250-1000 Hz). Study sample: We tested 15 patients (30 ears) diagnosed with definite bilateral MD based on the clinical criteria proposed by the American Academy of Otolaryngology Head and Neck surgery, 1995 (assumed gold standard) and 20 controls. Results: 500 Hz cVEMP threshold was the most promising parameter to differentiate MD ears from controls. cVEMP and ECochG showed high specificity (83.3 and 100%, respectively) and low to moderate sensitivity (22.2 and 71.4%) for long term MD. ECochG sensitivity increased to 89% during a symptomatic period, compared to 33% for cVEMP. However, ECochG can be difficult to schedule during symptomatic periods. Sensitivity of cVEMP for the diagnosis of MD appears limited. Conclusions: ECochG has higher sensitivity than cVEMP in the diagnosis of M eni ere's patients, but the ECochG SP/AP amplitude ratio measure is not perfect for the diagnosis of MD.

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Section: Introductionsupporting

confidence: 59%

Comparing the sensitivity and specificity of cervical vestibular-evoked myogenic potentials and electrocochleography in the diagnosis of Ménière’s disease

Obeidat

Bell

2019

International Journal of Audiology

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“…Therefore, a low-cost non-MRI-dependent diagnostic proxy for ELH is needed. ECochG is a method of directly recording the electrical activity of the cochlea and the acoustic nerve in response to acoustic stimuli ( 17 , 18 ). It has been recognized that ECochG is a valuable tool in the diagnosis of MD due to its sensitivity to the hydrops in the membranous labyrinth ( 18 , 19 ).…”

Section: Introductionmentioning

confidence: 99%

The Correlation of a 2D Volume-Referencing Endolymphatic-Hydrops Grading System With Extra-Tympanic Electrocochleography in Patients With Definite Ménière's Disease

Zhang

Zheng

et al. 2021

Front. Neurol.

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Background: Although magnetic resonance imaging (MRI) of the membranous labyrinth and electrocochleography (ECochG) have been used to diagnose endolymphatic hydrops (ELH) in patients with Ménière's disease (MD), the relationship between imaging and ECochG is not well-documented.Objectives: This study evaluates the ELH using 3D-FLAIR MRI and extra-tympanic ECochG (ET-ECochG) and correlates the results from 3D-FLAIR MRI to those from ET-ECochG.Materials and Methods: 3D-FLAIR MRI images of 50 patients were assessed using a 2D volume-referencing grading system (VR scores, relative scores according to the known volumes of the cochlea, vestibule, and semicircular canals). Forty healthy subjects were included and compared to 51 definite MD ears of 50 patients while analyzing the ET-ECochG, which used a self-made bronze foil electrode. The amplitude ratio of the summating potential (SP) to the action potential (AP) (SP/AP) and the area ratio of SP to AP (Asp/Aap) were collected. Relative ELH grade scores were then correlated to ET-ECochG (SP/AP, Asp/Aap).Results: The VR scores showed a better correlation (r = 0.88) with the pure tone average (PTA), disease duration, and vertigo frequency of MD than the Bernaerts scores (grading the cochlea and vestibule separately) (r = 0.22). The SP/AP and Asp/Aap of the unilateral MD patients were statistically comparable to those measured in contralateral ears and the results between the definite MD ears with healthy ears were statistically comparable (p < 0.05). In a ROC analysis Asp/Aap (area under curve, AUC 0.98) significantly (p = 0.01) outperformed SP/AP (AUC 0.91). The total score of ELH, vestibular ELH, and cochlear ELH were also correlated with SP/AP and Asp/Aap. The strongest correlation was found between the Asp/Aap and cochlear ELH (r = 0.60).Conclusion: The 2D volume-referencing grading system was more meaningful than the Bernaerts scores. A correlation was found between ELH revealed by 3D-FLAIR MRI and the SP/AP of ET-ECochG in evaluating definite MD patients. The Asp/Aap appeared a more sensitive and reliable parameter than SP/AP for diagnosing the ELH of the membranous labyrinth.

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“…Compared with DPOAE, cochlear electrograms can help us locate the lesions of AN [44]. The -SP wave reflects the fractional depolarization process after the inner hair cells are subjected to the acoustic signal and is the maximum amplitude recorded by the needle electrode placed on the cochlear or round window through the tympanic membrane [45]. The -SP waves are mainly derived from inner hair cells, and their amplitude and latency are objective indicators of the function of inner hair cells.…”

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confidence: 99%

High Frequency of AIFM1 Variants and Phenotype Progression of Auditory Neuropathy in a Chinese Population

Wang

Dai

et al. 2020

Neural Plasticity

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To decipher the genotype-phenotype correlation of auditory neuropathy (AN) caused by AIFM1 variations, as well as the phenotype progression of these patients, exploring the potential molecular pathogenic mechanism of AN. A total of 36 families of individuals with AN (50 cases) with AIFM1 variations were recruited and identified by Sanger sequencing or next-generation sequencing; the participants included 30 patients from 16 reported families and 20 new cases. We found that AIFM1-positive cases accounted for 18.6% of late-onset AN cases. Of the 50 AN patients with AIFM1 variants, 45 were male and 5 were female. The hotspot variation of this gene was p.Leu344Phe, accounting for 36.1%. A total of 19 AIFM1 variants were reported in this study, including 7 novel ones. A follow-up study was performed on 30 previously reported AIFM1-positive subjects, 16 follow-up cases (53.3%) were included in this study, and follow-up periods were recorded from 1 to 23 years with average 9.75±9.89 years. There was no hearing threshold increase during the short-term follow-up period (1-10 years), but the low-frequency and high-frequency hearing thresholds showed a significant increase with the prolongation of follow-up time. The speech discrimination score progressed gradually and significantly along with the course of the disease and showed a more serious decline, which was disproportionately worse than the pure tone threshold. In addition to the X-linked recessive inheritance pattern, the X-linked dominant inheritance pattern is also observed in AIFM1-related AN and affects females. In conclusion, we confirmed that AIFM1 is the primary related gene among late-onset AN cases, and the most common recurrent variant is p.Leu344Phe. Except for the X-linked recessive inheritance pattern, the X-linked dominant inheritance pattern is another probability of AIFM1-related AN, with females affected. Phenotypical features of AIFM1-related AN suggested that auditory dyssynchrony progressively worsened over time.

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The Clinical Uses of Electrocochleography

Cited by 38 publications

References 10 publications

Comparing the sensitivity and specificity of cervical vestibular-evoked myogenic potentials and electrocochleography in the diagnosis of Ménière’s disease

Comparing the sensitivity and specificity of cervical vestibular-evoked myogenic potentials and electrocochleography in the diagnosis of Ménière’s disease

The Correlation of a 2D Volume-Referencing Endolymphatic-Hydrops Grading System With Extra-Tympanic Electrocochleography in Patients With Definite Ménière's Disease

High Frequency of AIFM1 Variants and Phenotype Progression of Auditory Neuropathy in a Chinese Population

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