The clinical value of interleukins-8, -10, and -17 in idiopathic granulomatous mastitis

Köksal, Hande; Vatansev, Hüsamettin; Artaç, Hasibe; Kadoglou, Naim

doi:10.1007/s10067-020-04925-8

Cited by 41 publications

(38 citation statements)

References 21 publications

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“…T H 17 cells will produce proinflammatory cytokines, IL-17, and IL-22 [ 24 ]. Our findings were compatible with the findings of a previous study which demonstrated that higher serum IL-17 concentration was found in IGM patients compared to HC [ 14 ]. The other study showed that the serum concentration of IL-22 and IL-23 was higher in IGM patients compared to HC; however, there was no statistically significant difference in serum IL-17 concentration [ 13 ].…”

Section: Discussionsupporting

confidence: 93%

“…This hypothesis is supported by the lymphocytes infiltration in pathological sections, effectiveness of GC treatment, and presence of extramammary manifestations [ 4 ]. Recent studies had also found higher serum concentrations of interleukin (IL)-8, IL-10, IL-17, IL-22, IL-23, and IL-33 in IGM patients than healthy controls (HC) [ 13 , 14 , 15 ]. However, the association between clinical and immunological features of IGM remains unrevealed.…”

Section: Introductionmentioning

confidence: 99%

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Serum C-Reactive Protein and Interleukin-6 Levels as Biomarkers for Disease Severity and Clinical Outcomes in Patients with Idiopathic Granulomatous Mastitis

Huang

Cheng

et al. 2021

JCM

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Idiopathic granulomatous mastitis (IGM) is a rare inflammatory breast disease mimicking breast cancer. Limited research has been conducted on the application of serum biomarkers. This study aims to investigate the association of serum biomarkers with disease severity in patients with IGM. From November 2011 to March 2020, medical records of patients with IGM were reviewed. Serum cytokine levels were measured in patients and healthy controls between July 2018 and March 2020. A total of 41 patients with histologically proven IGM were found. Serum interleukin (IL)-6 level was significantly higher in patients with IGM (n = 11) than healthy controls (n = 7). Serum IL-6 and C-reactive protein (CRP) levels were significantly higher in patients with severe disease than mild and moderate disease. Serum IL-6 (Spearman’s ρ = 0.855; p < 0.001) and CRP (Spearman’s ρ = 0.838; p = 0.001) levels were associated with time to resolution. A higher serum CRP level was associated with a longer time to resolution (B = 0.322; p < 0.001) in multiple linear regression analysis. Serum IL-6 and CRP levels can be used as biomarkers for the evaluation of disease severity in IGM. IL-6 may play a crucial role in the immunopathology of IGM.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Serum C-Reactive Protein and Interleukin-6 Levels as Biomarkers for Disease Severity and Clinical Outcomes in Patients with Idiopathic Granulomatous Mastitis

Huang

Cheng

et al. 2021

JCM

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“…Therefore, as a plausible mechanism for EN development in severe IGM cases, increased immune complexes, cytokines, and chemokine levels in the blood might be triggering septal panniculitis by causing neutrophilic recruitment and activation in pretibial subcutaneous tissue. 38,39 EN tends to be self-limited, and the most common approach is the treatment of any underlying disorders and supportive therapy.…”

Section: F I G U R E 3 Erythema Nodosum In the Lower Extremitymentioning

confidence: 99%

Patients with idiopathic granulomatous mastitis accompanied by erythema nodosum

Bahçe

Aktaş

2020

Int J Clin Pract

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Background Idiopathic granulomatous mastitis (IGM) is a rare, chronic inflammatory disease of the breast. The aetiology is unknown. Erythema nodosum (EN) is a rare skin disease associated with IGM. EN is a disease in which the aetiologic factors include infection, malignancy, autoimmune diseases, and pregnancy. Objective The objective of this study was to evaluate the incidence and coexistence of EN with IGM and the approach to treatment. Methods Patients who were admitted to the General Surgery and Dermatology Department of our hospital and diagnosed with EN and IGM were evaluated. Demographic data, symptoms, examination findings, number of birth, smoking, diagnosis and treatment methods, recurrence, and follow‐up periods of the patients were evaluated. Results EN was seen in six of the patients admitted to the clinic for IGM. Four patients with EN had pregnancy and all had arthritis. Two patients were not pregnant. Oral methylprednisolone treatment was started in patients whose IGM diagnosis was verified pathologically. Conclusion IGM may be associated with extramammary symptoms such as EN, arthralgia, and episcleritis. These extramammary findings suggest that IGM may be an autoimmune disease. For this reason, breast examination and history of IGM of the breast should be questioned in female patients admitted to different clinics with EN. This way, delays in the diagnosis and treatment of IGM can be prevented.

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“…Nowadays, autoimmunity is the most accused factor in etiology and pathogenesis of IGM 20. Higher incidences of some human leukocyte antigens (HLA) and changes in cytokine profiles suggest the possibility of autoimmunity and immune dysregulation in etiology of IGM 21,22. Therefore, as a plausible mechanism for EN developmentin severe IGM cases, increased immune complexes, cytokines, and chemokine levels in the blood might be triggering septal panniculitis by causing neutrophilic recruitment and activation in pretibial subcutaneous tissue.…”

mentioning

confidence: 99%

Idiopathic granulomatous mastitis with erythema nodosum: Is it a variant of clinical presentation indicating treatment resistance? A retrospective cohort study

2020

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Idiopathic granulomatous mastitis (IGM) rarely occurs with erythema nodosum (EN) as a systemic finding. However, the impact of their coexistence on disease severity and response to steroids has not been investigated yet. Patients diagnosed with IGM between September 2014 and October 2018 were divided into two groups according to the presence or absence of EN during the first admission retrospectively. The IGM was more severe in patients with EN as it was presented more often as bilateral and diffuse involvement of the breast. Findings of mastitis did not resolve with steroids in 50% of this group. Repetitive excisions and mastectomy with reconstructions were required to control the disease. Coexistence of EN and IGM was found to be related to bilateral and aggressive involvement, which could be associated with insufficient response to steroids. Associated patients should be informed in terms of the aggressive course, and surgery can be highlighted as a first-line treatment.

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The clinical value of interleukins-8, -10, and -17 in idiopathic granulomatous mastitis

Cited by 41 publications

References 21 publications

Serum C-Reactive Protein and Interleukin-6 Levels as Biomarkers for Disease Severity and Clinical Outcomes in Patients with Idiopathic Granulomatous Mastitis

Serum C-Reactive Protein and Interleukin-6 Levels as Biomarkers for Disease Severity and Clinical Outcomes in Patients with Idiopathic Granulomatous Mastitis

Patients with idiopathic granulomatous mastitis accompanied by erythema nodosum

Idiopathic granulomatous mastitis with erythema nodosum: Is it a variant of clinical presentation indicating treatment resistance? A retrospective cohort study

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