1997
DOI: 10.1016/s0046-8177(97)90005-8
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The clinicopathological characteristics of gonadotroph cell adenoma: A study of 118 cases

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Cited by 51 publications
(28 citation statements)
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“…Similar figures have been reported by others, with NFPAs representing 65 -84% of all cases, followed by GH-(9 -17%), PRL-(4.5 -10%) and adrenocorticotrophin (ACTH)-(0 -6%) secreting adenomas, respectively (1,3,4,6,8). Noteworthy is that some studies suggest that the incidence of gonadotroph adenomas, usually included in the NFPA group, tends to increase with age and to be more frequently diagnosed above 60 years, especially in men (12,13). Most PAs in the elderly are slowly growing, and this can be supported by the low rates of cell proliferation commonly reported in this age group (14).…”
Section: Pituitary Pathologymentioning
confidence: 99%
See 1 more Smart Citation
“…Similar figures have been reported by others, with NFPAs representing 65 -84% of all cases, followed by GH-(9 -17%), PRL-(4.5 -10%) and adrenocorticotrophin (ACTH)-(0 -6%) secreting adenomas, respectively (1,3,4,6,8). Noteworthy is that some studies suggest that the incidence of gonadotroph adenomas, usually included in the NFPA group, tends to increase with age and to be more frequently diagnosed above 60 years, especially in men (12,13). Most PAs in the elderly are slowly growing, and this can be supported by the low rates of cell proliferation commonly reported in this age group (14).…”
Section: Pituitary Pathologymentioning
confidence: 99%
“…However, up to 40 -50% of gonadotroph adenomas can be simply recognized in men on the basis of elevated follicle-stimulating hormone or luteinizing hormone (LH) levels (12,13). Determination of a-and b-follicle-stimulating hormone, and bLH, especially after thyrotrophin-releasing hormone stimulation, may increase the diagnostic sensitivity up to 70% in male and 50% in female patients, respectively, although this cannot be routinely proposed (12).…”
Section: Peculiarity Of Bioclinical Endocrine Changes In the Elderlymentioning
confidence: 99%
“…The subgroups of Go and NC adenomas share well known histomorphological similarities like oncocytic cell change [5,52,53] and pseudorosette-like architecture of polar cells surrounding blood vessels [5]. NC lack markers for AH differentiation even on ultrastructural level and show no immunohistochemically detectable hormone expression.…”
Section: Discussionmentioning
confidence: 99%
“…Gonadotroph tumors comprise 15-35% of all pituitary adenomas, and most of the clinically non-functioning adenomas, which constitute approximately one-third of all tumors of the anterior pituitary, are actually gonadotropin-secreting adenomas or gonadotroph adenomas (3)(4)(5). Although most gonadotroph adenomas are benign, slow-growing tumors, some are characterized by fast invasive growth, increased mitotic activity, a Ki-67 labeling index greater than 3%, and positive p53 immunoreactivity (6).…”
Section: Introductionmentioning
confidence: 99%