The clinicopathological correlation of epithelial subtyping in thymoma: A study of 112 consecutive cases

Pan, Chin-Chen; Wu, Hung‐Ming; Yang, Ching‐Fen; Chen, Winby York-Kwan; Chiang, Hung

doi:10.1016/0046-8177(94)90008-6

Cited by 61 publications

(32 citation statements)

References 29 publications

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“…In the present study, thymomas were grouped as noninvasive (Masaoka stage I) or invasive (Masaoka stage II to IV). In contrast to other series, [5][6][7][8][9][10][11]15,25 although advanced clinical stage did tend to predict a poorer prognosis, the clinical (Masaoka) stage failed to reach statistical significance as an independent predictor of overall survival. The presence of either local or systemic symptoms also failed to reach statistical significance for independent predictive value.…”

Section: Discussioncontrasting

confidence: 43%

“…6,8,10,[12][13][14][15]17,21,24,25,27,31,40 We found that the L/B pathologic classification is an independent predictor of overall survival, patients with predominantly epithelial thymoma or thymic carcinoma having a significantly decreased overall survival rate. (The epithelial thymomas and thymic carcinomas were grouped together because of the small number of thymic carcinomas in the series.…”

Section: Discussionmentioning

confidence: 75%

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Clinical and Pathologic Predictors of Survival in Patients With Thymoma

et al. 1999

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ObjectiveTo evaluate the Johns Hopkins Hospital experience with 136 thymomas over the past 40 years. This number of patients allowed quantitative estimation of the independent influence of common clinicopathologic risk factors using multivariate analysis. Summary Background DataThymomas vary widely in terms of recurrence and influence on overall survival. Several series have indicated the importance of initial tumor invasion, as well as the extent of surgical resection, as predictors of recurrence and survival after thymoma resection. However, findings have been equivocal when other predictors of prognosis were examined. MethodsThe authors evaluated 136 patients seen at the Johns Hopkins Hospital between 1957 and 1997 with a pathologic diagnosis of thymoma. Demographic information, clinical staging data, surgical and adjuvant treatment details, and patient follow-up data were obtained from the patient record and from detailed patient or family interviews. Microscopic sections of all 136 patients were reviewed by two pathologists blinded to the clinical data. All data were analyzed by multivariate Cox regression analysis, which allowed the quantification of the independent predictive value of 12 putative clinicopathologic prognostic indicators. ResultsCompleteness of follow-up was 99%, 99%, and 98% of eligible patients at 5, 10, and 15 years, respectively. Forty percent of the patients had associated myasthenia gravis and 27% had a secondary primary malignancy. Overall patient survival rates were 71%, 56%, 44%, 38%, and 33% at 5, 10, 15, 20, and 25 years, respectively. Overall, the thymoma-related mortality rate was 14%; the nonthymoma-related mortality rate was 26%. Incomplete resection, preoperative absence of myasthenia gravis, and advanced Lattes/Bernatz pathologic class were found to be independent predictors of poorer overall survival. ConclusionsThese findings support a policy of aggressive, complete surgical resection of all thymomas when feasible. Thymoma behaves as a rather indolent tumor, with most deaths from causes unrelated to thymoma or its direct treatment. Clinicians should have an increased awareness of the possibility of second primary malignancies in patients with thymoma.

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Section: Discussioncontrasting

confidence: 43%

Section: Discussionmentioning

confidence: 75%

Clinical and Pathologic Predictors of Survival in Patients With Thymoma

et al. 1999

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“…Dentre os métodos existentes para mensurar o grau de invasão do tumor, o sistema classificatório proposto por Masaoka et al (8) é considerado por muitos autores o fator prognóstico mais importante (21)(22)(23)31) . Vários autores (7,(32)(33)(34)(35)(36) têm enfatizado o valor prognósti-co de um novo método histopatológico de classificação (37) , mas a superioridade de sua classificação não foi ainda confirmada (38,39) . Nossa série de pacientes mostrou-se em concordância com os principais estudos já discutidos.…”

Section: Discussionunclassified

Timoma: discussão sobre tratamento e prognóstico

Pêgo‐Fernandes¹,

Ebaid²,

Galizia³

et al. 2001

J. Pneumologia

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ObjetivoLocalizado em sua porção anterior, é o tumor mais freqüente desse compartimento, compreendendo aproximadamente de 20 a 30% das massas mediastinais em adultos (1) . Os pacientes com timoma podem apresentar quadro clínico não muito específico: tosse, dispnéia, dor torácica, perda de peso, queda do estado geral. Porém, alguns pacientes são diagnosticados por radiografias de tórax em exames de rotina -que mostram opacidade homogênea no mediastino ântero-superior -ou por apresentar miastenia gravis associada (2) . Grande parte dos pacientes que apresentam timoma é de portadores de outras doenças auto-imunes ou endócrinas. Cerca de 27% dos pacientes com miastenia gravis apresentam timoma -83% dos homens com miastenia gravis entre 50 e 60 anos possuem timoma (3) -e 20-40% dos pacientes com timoma apresentam miastenia gravis. Artrite reumatóide, miosite e aplasia por células vermelhas puras são outras síndromes que podem vir associadas ao timoma (4) . O timoma está mais presente nas 5 a e 6 a décadas de vida, sendo menos freqüente em pacientes abaixo de 40 INTRODUÇÃO Timoma, um tumor infreqüente e de crescimento lento, é usualmente confinado localmente ao mediastino.

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“…Furthermore, there have also been reports of mediastinal recurrence or metastasis of this type of tumor. 1,7,15 Medullary thymomas are generally innocuous, but are not absolutely benign. 15 Thus the term "extremely low-grade malignancy," used here, more adequately describes these tumors than the term "benign."…”

Section: Discussionmentioning

confidence: 99%

“…1,7,15 Medullary thymomas are generally innocuous, but are not absolutely benign. 15 Thus the term "extremely low-grade malignancy," used here, more adequately describes these tumors than the term "benign." The extremely low-grade malignancy group corresponds to predominantly spindle cell thymoma and predominantly mixed (polygonal and spindle cell) thymoma in the traditional system, and to medullary and mixed corticomedullary thymoma in the M-K-M system.…”

Section: Discussionmentioning

confidence: 99%