The Clustering of Other Chronic Inflammatory Diseases in Inflammatory Bowel Disease: A Population-Based Study

Bernstein, Çharles N.; Wajda, André; Blanchard, James

doi:10.1053/j.gastro.2005.06.021

Cited by 505 publications

(340 citation statements)

References 64 publications

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“…On the basis of administrative data from health databases, they show higher prevalence of asthma in both UC and CD patients [7], or higher prevalence of UC and CD in asthma patients group [7,20,21], compared to control groups. Bernstein et al [7] found that the risk of asthma was 50-70% higher in their patients with UC and 30-40% higher in their patients with CD, compared to population-based controls. Data from the same studied population, but looked at in a different way, indicated that IBD risk in asthma patients is also higher than in the control group: prevalence ratio for UC was 1.56 and for CD 1.38.…”

Section: Epidemiologymentioning

confidence: 99%

“…Genetic predisposition, environmental factors and abnormal immune processes are believed to be involved [2]. In 15-20% of UC patients and 20-40% of CD patients, so-called extraintestinal manifestations (EIM) of IBD are present [3][4][5][6][7]. Most commonly, involvement of central and peripheral joints, skin, eyes and the hepatobiliary system is seen [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…In 15-20% of UC patients and 20-40% of CD patients, so-called extraintestinal manifestations (EIM) of IBD are present [3][4][5][6][7]. Most commonly, involvement of central and peripheral joints, skin, eyes and the hepatobiliary system is seen [3][4][5][6][7]. It is most probably related to the presence of circulating antibodies against a colonic epithelial antigen that is shared among these organs [8].…”

Section: Introductionmentioning

confidence: 99%

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Respiratory System Involvement in Inflammatory Bowel Diseases

Kacprzak¹,

Szturmowicz²,

Kuś³

2017

Advances in Respiratory Medicine

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Section: Epidemiologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Respiratory System Involvement in Inflammatory Bowel Diseases

Kacprzak¹,

Szturmowicz²,

Kuś³

2017

Advances in Respiratory Medicine

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“…Other immune-mediated disorders are more frequent among IBD patients, notably, ankylosing spondylitis, asthma, psoriasis and multiple sclerosis. 3 IBD may occur at any age, although the peak age at onset is the third decade of life. Both CD and UC have a prevalence of 100-200 per 100 000 in the United States.…”

Section: Introductionmentioning

confidence: 99%

An SNP linkage scan identifies significant Crohn's disease loci on chromosomes 13q13.3 and, in Jewish families, on 1p35.2 and 3q29

et al. 2008

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Inflammatory bowel disease (IBD) is a complex genetic disorder of two major phenotypes, Crohn's disease (CD) and ulcerative colitis (UC), with increased risk in Ashkenazi Jews. Twelve genome-wide linkage screens have identified multiple loci, but these screens have been of modest size and have used low-density microsatellite markers. We, therefore, performed a high-density single-nucleotide polymorphism (SNP) genome-wide linkage study of 993 IBD multiply affected pedigrees (25% Jewish ancestry) that contained 1709 IBD-affected relative pairs, including 919 CD-CD pairs and 312 UC-UC pairs. We identified a significant novel CD locus on chromosome 13p13.3 (peak logarithm of the odds (LOD) score ¼ 3.98) in all pedigrees, significant linkage evidence on chromosomes 1p35.1 (peak LOD score ¼ 3.5) and 3q29 (peak LOD score ¼ 3.19) in Jewish CD pedigrees, and suggestive loci for Jewish IBD on chromosome 10q22 (peak LOD score ¼ 2.57) and Jewish UC on chromosome 2q24 (peak LOD score ¼ 2.69). Nominal or greater linkage evidence was present for most previously designated IBD loci (IBD1-9), notably, IBD1 for CD families at chromosome 16q12.1 (peak LOD score ¼ 4.86) and IBD6 in non-Jewish UC families at chromosome 19p12 (peak LOD score ¼ 2.67). This study demonstrates the ability of high information content adequately powered SNP genome-wide linkage studies to identify loci not observed in multiple microsatellite-based studies in smaller cohorts.

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“…Several studies in adult populations have described increased comorbidity with other immune-mediated diseases including asthma, arthritis, rheumatoid arthritis, ankylosing spondylitis, and psoriasis (6)(7)(8)(9)(10)(11). A pediatric study described a particularly strong association of IBD with rheumatoid arthritis and systemic lupus in children compared with previous adult studies (6).…”

mentioning

confidence: 99%