The co-occurrence of multiple sclerosis and type 1 diabetes: Shared aetiologic features and clinical implication for MS aetiology

Tettey, Prudence; Simpson, Steve; Taylor, Bruce; Mei, Ingrid van der

doi:10.1016/j.jns.2014.11.019

Cited by 44 publications

(43 citation statements)

References 90 publications

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“…Defining shared risk factors in ostensibly distinct clinical diseases with etiological, pathophysiological, and molecular shared substrates is not a new idea but has been rarely exploited in the fashion of systems medicine to connect oral health and a systemic gastrointestinal disorder, such as Crohn's disease. Identification of common risk factors had been demonstrated on multiple sclerosis and type 1 diabetes (Tettey et al, 2015), celiac disease and rheumatoid arthritis (Zhernakova et al, 2011), and coronary artery disease and periodontitis (Schaefer et al, 2015). Today, susceptibility testing with omics biotechnologies has become available for several chronic diseases, offering hope for early diagnosis and prevention.…”

Section: Discussionmentioning

confidence: 99%

Two Cheers for Crohn's Disease and Periodontitis: Beta-Defensin-2 as an Actionable Target to Intervene on Two Clinically Distinct Diseases

Keskin

Zeidán-Chuliá

Gürsoy

et al. 2015

OMICS: A Journal of Integrative Biology

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Recent advances in multi-omics approaches encompassing genomics, transcriptomics, proteomics, and metabolomics offer hitherto unprecedented insights on common complex human diseases. A unique angle pertinent for both diagnostic and therapeutic sciences involves rethinking clinically distinct diseases with a view to their shared molecular targets, interactomes, and pathophysiologies. Reflecting at a scale of disease-to-disease associations might help clinicians, public health practitioners, drug and biotechnology developers, and associated knowledge industries in the current era. This review article examines the hypothesis that "Intersecting Molecular Pathways Permit Interventions on Multiple Clinical Endpoints", thus uniquely bringing together Crohn's disease and periodontitis. Furthermore, we propose a novel connector molecular target between these two ostensibly distinct diseases at a clinical level, human beta defensin (hBD)-2, and suggest pathways by which hBD-2 can conceivably connect Crohn's disease and periodontitis by virtue of regulating the innate-immune response. We conclude by emphasizing different approaches where hBD-2 can be employed as a diagnostic and therapeutic tool to improve the quality of life of susceptible individuals and minimize the economic costs of these two major global public health problems. The strategy presented here also presents potentials for targeting of multiple diseases through a unique "nodal molecular target" that "speaks to" multiple clinical endpoints.

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Section: Discussionmentioning

confidence: 99%

Two Cheers for Crohn's Disease and Periodontitis: Beta-Defensin-2 as an Actionable Target to Intervene on Two Clinically Distinct Diseases

Keskin

Zeidán-Chuliá

Gürsoy

et al. 2015

OMICS: A Journal of Integrative Biology

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“…The co-occurrence of MS and diabetes mellitus has been reported by a number of studies. In particular as mentioned in [21] for the combined effect of diabetes mellitus type 1 and type 2 there is evidence that this is associated with a worse progression of disability compared to MS patients without type 1 or type 2 diabetes. This is in accordance with clinical profile we identified using privileged information which indicates that the neuropathology associated with this form of diabetes might influence the disease course (symptoms related to lesions, spinal cord brain lesion) and contribute to the severity of MS (short DOD).…”

Section: Comparison Between Nmf and Cnmf Clustersmentioning

confidence: 92%

Discovering Potential Clinical Profiles of Multiple Sclerosis from Clinical and Pathological Free Text Data with Constrained Non-negative Matrix Factorization

Acquarelli

Bianchini²,

Marchiori

2016

Lecture Notes in Computer Science

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Abstract. Constrained non-negative matrix factorization (CNMF) is an effective machine learning technique to cluster documents in the presence of class label constraints. In this work, we provide a novel application of this technique in research on neuro-degenerative diseases. Specifically, we consider a dataset of documents from the Netherlands Brain Bank containing free text describing clinical and pathological information about donors affected by Multiple Sclerosis. The goal is to use CNMF for identifying clinical profiles with pathological information as constraints. After pre-processing the documents by means of standard filtering techniques, a feature representation of the documents in terms of bi-grams is constructed. The high dimensional feature space is reduced by applying a trimming procedure. The resulting datasets of clinical and pathological bi-grams are then clustered using non-negative matrix factorization (NMF) and, next, clinical data are clustered using CNMF with constraints induced by the clustering of pathological data. Results indicate the presence of interesting clinical profiles, for instance related to vision or movement problems. In particular, the use of CNMF leads to the identification of a clinical profile related to diabetes mellitus. Pathological characteristics and duration of disease of the identified profiles are analysed. Although highly promising, results of this investigation should be interpreted with care due to the relatively small size of the considered datasets.

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“…Although an environmental component is highly suspected, environmental factors have not yet been identified. An increased incidence of type 1 diabetes is associated with both MS [187] and autism [188]. The disease is characterized by an autoimmune reaction to various proteins expressed in the pancreatic islet cells.…”

Section: Type 1 Diabetesmentioning

confidence: 99%

Glyphosate pathways to modern diseases VI: Prions, amyloidoses and autoimmune neurological diseases

Samsel¹,

Seneff²

2017

JBPC

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The co-occurrence of multiple sclerosis and type 1 diabetes: Shared aetiologic features and clinical implication for MS aetiology

Cited by 44 publications

References 90 publications

Two Cheers for Crohn's Disease and Periodontitis: Beta-Defensin-2 as an Actionable Target to Intervene on Two Clinically Distinct Diseases

Two Cheers for Crohn's Disease and Periodontitis: Beta-Defensin-2 as an Actionable Target to Intervene on Two Clinically Distinct Diseases

Discovering Potential Clinical Profiles of Multiple Sclerosis from Clinical and Pathological Free Text Data with Constrained Non-negative Matrix Factorization

Glyphosate pathways to modern diseases VI: Prions, amyloidoses and autoimmune neurological diseases

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