The CO2-SFE crude lipid extract and the free fatty acid extract from Perna canaliculus have anti-inflammatory effects on adjuvant-induced arthritis in rats

Singh, Mukesh; Hodges, Lynn D.; Wright, Paul; Cheah, Daphne M. Y.; Wynne, Paul; Kalafatis, Nicolette; Macrides, Theodore A.

doi:10.1016/j.cbpb.2007.09.015

Cited by 19 publications

(13 citation statements)

References 20 publications

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“…The efficacy results for PCSO-524™ oil are similar to those reported in other studies [3,11,12,13,18,19,20]. In comparison, patients from Group B, who were treated with fish oil, did not show a notable reduction in pain, there was no significant improvement of mobility or activity and only 71% tolerance.…”

Section: Discussionsupporting

confidence: 87%

Perna canaliculus Lipid Complex PCSO-524™ Demonstrated Pain Relief for Osteoarthritis Patients Benchmarked against Fish Oil, a Randomized Trial, without Placebo Control

Zawadzki¹,

Janosch²,

Szechiński³

2013

Marine Drugs

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Osteoarthritis (OA) typically generates pain, reduced mobility and reduced quality of life. Most conventional treatments for osteoarthritis, such as non-steroidal anti-inflammatory drugs (NSAIDs) and simple analgesics, have side effects. PCSO-524™, a non polar lipid extract from the New Zealand Green Lipped Mussel, is rich in omega-3 fatty acids and has been shown to reduce inflammation in both animal studies and patient trials. This OA trial examined pain relief changes in relation to quality of life and safety of use for OA patients who took PCSO-524™ compared with patients who took fish oil (containing an industry standard EPA-18% and DHA-12% blend). PCSO-524™ patients showed a statistically significant improvement compared with patients who took fish oil. There was an 89% decrease in their pain symptoms and 91% reported an improved quality of life. Patients treated with fish oil showed significantly less improvement and a greater level of physical discomfort during the study. These results suggest that PCSO-524™ might offer a potential alternative complementary therapy with no side effects for OA patients.

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Section: Discussionsupporting

confidence: 87%

Perna canaliculus Lipid Complex PCSO-524™ Demonstrated Pain Relief for Osteoarthritis Patients Benchmarked against Fish Oil, a Randomized Trial, without Placebo Control

Zawadzki¹,

Janosch²,

Szechiński³

2013

Marine Drugs

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“…HMLE (100 mg/kg) demonstrated a strong anti-inflammatory effect by diminishing the hind paw swelling and arthritis index, and improving the body weight gain in both AIA and CIA rats. Many previous animal studies have demonstrated that GMLE can reduce inflammation in arthritic rats [6,12] and dogs [7,23]. In addition, numerous clinical trials have shown a strong therapeutic activity of GMLE in patients suffering from RA and OA [11,24].…”

Section: Resultsmentioning

confidence: 99%

“…Numerous animal and clinical studies have demonstrated that GMLE has anti-inflammatory, anti-arthritic, and gastro-protective properties [6,7,8,9,10,11]. It has been proposed that the active ingredients in GLME are concentrated long chain n -3 polyunsaturated fatty acids (PUFAs) which can inhibit membrane arachidonic acid (AA, C20:4 n -6) metabolism by blocking the lipoxygenase (LOX) and cyclo-oxygenase (COX) pathways, thus, decreasing prostaglandin and leukotriene synthesis and down regulating the inflammatory sequence [12,13]. In vitro studies have shown that GMLE can inhibit leukotriene B 4 (LTB 4 ) production in calcium ionophore-stimulated human neutrophils [6], and in interleukin-4-induced human monocytes [14].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Activity and Mechanism of a Lipid Extract from Hard-Shelled Mussel (Mytilus Coruscus) on Chronic Arthritis in Rats

Li¹,

Fu²,

Zheng³

et al. 2014

Marine Drugs

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The present study was designed to investigate the anti-inflammatory activity and mechanism of a lipid extract from hard-shelled mussel (Mytilus coruscus) on adjuvant-induced (AIA) and collagen-induced arthritis (CIA) in rats. AIA and CIA rats that received hard-shelled mussel lipid extract (HMLE group) at a dose of 100 mg/kg demonstrated significantly lower paw swelling and arthritic index, but higher body weight gain than those which received olive oil (control group). Similar results were found in arthritic rats that received New Zealand green-lipped mussel lipid extract (GMLE) at the same dosage. The levels of leukotriene B4 (LTB4), prostaglandin E2 (PGE2), thromboxane B2 (TXB2) in the serum, and interleukin-1β (IL-1β), IL-6, interferon-γ (INF-γ), tumor necrosis factor-α (TNF-α) in the ankle joint synovial fluids of HMLE group rats were significantly lower than those of control group. However, the levels of IL-4 and IL-10 in HMLE group rats were significantly higher than those in the control group. Decreased mRNA expressions of matrix metalloproteinase 1 (MMP1) and MMP13, but increased tissue inhibitor of metalloproteinase 1 (TIMP1) were observed in the knee joint synovium tissues of HMLE group rats when compared with the control group. No hepatotoxicity was observed in both HMLE and GMLE group rats. The present results indicated that HMLE had a similarly strong anti-inflammatory activity as GMLE. Such a strong efficacy could result from the suppression of inflammatory mediators (LTB4, PGE2, TXB2), pro-inflammatory cytokines (IL-1β, IL-6, INF-γ, TNF-α) and MMPs (MMP1, MMP13), and the promotion of anti-inflammatory cytokines (IL-4, IL-10) and TIMPs (TIMP1) productions.

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“…The anti-inflammatory effects of greenlipped mussel have previously been attributed to a proteinaceous macromolecule (Couch et al, 1982) or a polysaccharide/protein (glycogen) component (Miller et al, 1993). However, the lipid fraction is currently believed to hold the most therapeutic potential (Singh et al, 2008;Wolyniak, Brenna, Murphy, & Sinclair, 2005). The anti-inflammatory activity of green-lipped mussel extract is said to vary in potency depending on the stability of the preparation.…”

Section: Mechanism Of Actionmentioning

confidence: 94%

An Evidence-Based Systematic Review of Green-Lipped Mussel (Perna canaliculus) by the Natural Standard Research Collaboration

Ulbricht

Chao

Costa

et al. 2009

Journal of Dietary Supplements

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A blinded review is conducted by multidisciplinary research-clinical faculty at major academic centers with expertise in epidemiology and biostatistics, pharmacology, toxicology, CAM research, and clinical practice. In cases of editorial disagreement, a three-member panel of the Editorial Board addresses conflicts, and consults experts when applicable. Authors of studies are contacted when clarification is required.

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The CO2-SFE crude lipid extract and the free fatty acid extract from Perna canaliculus have anti-inflammatory effects on adjuvant-induced arthritis in rats

Cited by 19 publications

References 20 publications

Perna canaliculus Lipid Complex PCSO-524™ Demonstrated Pain Relief for Osteoarthritis Patients Benchmarked against Fish Oil, a Randomized Trial, without Placebo Control

Perna canaliculus Lipid Complex PCSO-524™ Demonstrated Pain Relief for Osteoarthritis Patients Benchmarked against Fish Oil, a Randomized Trial, without Placebo Control

Anti-Inflammatory Activity and Mechanism of a Lipid Extract from Hard-Shelled Mussel (Mytilus Coruscus) on Chronic Arthritis in Rats

An Evidence-Based Systematic Review of Green-Lipped Mussel (Perna canaliculus) by the Natural Standard Research Collaboration

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