The collagenolytic effects of the traditional Chinese medicine preparation, Han-Dan-Gan-Le, contribute to reversal of chemical-induced liver fibrosis in rats

Li, Chengxiu; Liu, Jun; Li, Ling; Cheng, Ming; Huang, Niannian; Liu, Jie; Waalkes, Michael P.

doi:10.1016/s0024-3205(02)02448-7

Cited by 48 publications

(35 citation statements)

References 9 publications

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“…wasting-thirst (Kuo, Tsai, Loke, Wu, & Chiou, 2009;Li et al, 2003;Shon, Kim, & Nam, 2002;Zhao, Ma, Zhu, Yu, & Weng, 2011). The main source of AR in China is the dried root of Astragalus membranaceus (Fisch.)…”

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confidence: 99%

Comparative analysis between aerial parts and roots (Astragali Radix) of astragalus membranaceus by NMR-based metabolomics

Wang

Jin

et al. 2017

Food and Agricultural Immunology

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Aerial parts of Astragalus membranaceus (APAM), which are derived from the overground part of Astragalus membranaceus consist of stems and leaves. The aim of this study was to provide a scientific basis for the comprehensive utilization of APAM. Nuclear magnetic resonance (NMR) was used to compare the chemical compositions of APAM and Astragali Radix (AR). The pharmacological effects of APAR and AR in cyclophosphamide (Cy)-induced mice were studied using 1 H NMR-based metabolomics. The results showed that APAM and AR were different from each other in primary and secondary metabolites, and they could recover the amounts of white blood cell, monocytes, lymphocyte and neutrophils content, IL-2 and IL-6; there was no significant difference in APAM and AR in terms of immune functions. The mechanisms of APAM and AR on leucopenia were probably related to energy metabolism, amino acids metabolism, and gut microbiota-related metabolism. ARTICLE HISTORY

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confidence: 99%

Comparative analysis between aerial parts and roots (Astragali Radix) of astragalus membranaceus by NMR-based metabolomics

Wang

Jin

et al. 2017

Food and Agricultural Immunology

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“…5) S. miltiorrhiza BGE (Danshen) is a well-known Chinese medicinal herb widely used to treat heart and cerebral diseases, 6) hepatitis, hemorrhage, and type 2 diabetes. 7,8) Salvianic acid A [2-(3,4-dihydroxyphenyl)-2-hydroxy-propanoic acid, SA] is one of the main active components of S. miltiorrhiza BGE. Previous studies have shown that SA is effectively able to protect myocardial mitochondrial membrane from ischemia-reperfusion injury, 9) inhibit lipid peroxidation of mitochondrial membrane of hepatic cells, 10) and prevent apoptosis of human neuroblastoma SH-SY5Y cells by antioxidant mechanism in vitro.…”

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confidence: 99%

Protective Effect of Salvianic Acid A on Acute Liver Injury Induced by Carbon Tetrachloride in Rats

Wang

Ma²,

Liu

et al. 2007

Biological & Pharmaceutical Bulletin

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“…Hepatic fibrosis represents the wound healing response of the liver to repeated liver injuries and is associated with increased inflammatory cell infiltration, which is a common stage in most liver diseases. If treated properly in this stage, hepatic fibrosis can be reversed and its progression can be prevented by increasing the intake of natural antioxidants, which offer great potential [20][21][22][23]. Selenium is unique among antioxidants in that it exerts its beneficial effects through its direct incorporation into proteins as amino acid selenocystine.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective, Immunomodulatory, and Anti-inflammatory Activities of Selenocystine in Experimental Liver Injury of Rats

Uzma

Kumar

Priyadarsini

2010

Biol Trace Elem Res

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The study was evaluated to investigate the efficacy of selenocystine (CysSeSeCys), a well-known organoselenium compound, on the prevention of carbon tetrachloride (CCl(4))-induced acute hepatic injury in Wistar rats. Forty healthy male Wistar rats were utilized in this study. Acute hepatotoxicity was induced by CCl(4) intoxication in rats. Serum biological analysis, oxidative stress, immune parameters, and gene expression of COX-2 and CYP2E1 were carried out. Pretreatment of CysSeSeCys prior to CCl(4) administration significantly prevented an increase in serum hepatic enzymatic activities. In addition, pretreatment of CysSeSeCys significantly prevented the formation of ROS, MDA, depletion of glutathione, and alteration of antioxidant enzyme activities in the liver of CCl(4)-intoxicated rats. This study also revealed that pretreatment with CysSeSeCys normalized the levels of interleukin 6 and10, IgG, and CD4 cell count. Pretreatment of CysSeSeCys significantly reversed COX-2 inflammatory response and the upregulation of CYP2E1 expression as well. Histopathological changes induced by CCl(4) were also significantly attenuated by CysSeSeCys pretreatment. CysSeSeCys has a potent hepatoprotective effect on CCl(4)-induced liver injury in rats through its antioxidative, immunomodulatory and anti-inflammatory activity.

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The collagenolytic effects of the traditional Chinese medicine preparation, Han-Dan-Gan-Le, contribute to reversal of chemical-induced liver fibrosis in rats

Cited by 48 publications

References 9 publications

Comparative analysis between aerial parts and roots (Astragali Radix) of astragalus membranaceus by NMR-based metabolomics

Comparative analysis between aerial parts and roots (Astragali Radix) of astragalus membranaceus by NMR-based metabolomics

Protective Effect of Salvianic Acid A on Acute Liver Injury Induced by Carbon Tetrachloride in Rats

Hepatoprotective, Immunomodulatory, and Anti-inflammatory Activities of Selenocystine in Experimental Liver Injury of Rats

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