Rivers are among the most degraded ecosystems on earth (Best, 2019). Water quality is impaired due to human activities such as agriculture and urbanization (Foley et al., 2005; Meybeck et al., 1990), and currently only 23% of earth's largest rivers flow uninterrupted to the ocean (Grill et al., 2019; Nilsson et al., 2005). Because large rivers integrate millions of kilometers of land area, understanding rivers and their impairments is inherently macroscale: both distant and local impacts generate the patterns we observe (Heffernan et al., 2014; McCluney et al., 2014). There is a profound need for integrative water quality measurements that are spatially explicit and globally scalable, as local and global changes impairing Earth's rivers cannot be fully understood using sparse, ground-based measurements (Stanley et al., 2019; Stets et al., 2020). Remote sensing enables spatially explicit, global observations of large rivers (Palmer et al., 2015). Satellite missions, such as the joint NASA/USGS Landsat mission, have been used for decades to measure river and lake water quality (Brezonik et al., 2005; Carpenter & Carpenter, 1983). However, measuring water quality at continental to global scales remains challenging over inland waters due to optical complexity, or the presence of multiple water quality constituents (Ross et al., 2019; Topp et al., 2020). The three main constituents are chlorophyll-a (chl-a), suspended sediment, and colored dissolved organic matter (CDOM) (Davies-Colley et al., 2003; Ritchie et al., 2003). These water quality constituents are ecologically important, control light availability for photosynthesis and photodegradation, and together determine the color of water which is an integrative measure of water quality (